Differential Mitochondrial, Oxidative Stress and Inflammatory Responses to SARS-CoV-2 Spike Protein Receptor Binding Domain in Human Lung Microvascular, Coronary Artery Endothelial and Bronchial Epithelial Cells

Differential Mitochondrial, Oxidative Stress and Inflammatory Responses to SARS-CoV-2 Spike Protein Receptor Binding Domain in Human Lung Microvascular, Coronary Artery Endothelial and Bronchial Epithelial Cells

Recent evidence indicates that the SARS-CoV-2 spike protein affects mitochondria with a cell type-dependent outcome. We elucidate the effect of the SARS-CoV-2 receptor binding domain (RBD) on the mitochondrial network and cristae morphology, oxygen consumption, mitoROS production, and inflammatory c...

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Bibliographic Details
Main Authors: Gabrielė Kulkovienė, Deimantė Narauskaitė, Agilė Tunaitytė, Augusta Volkevičiūtė, Zbigniev Balion, Olena Kutakh, Dovydas Gečys, Milda Kairytė, Martyna Uldukytė, Edgaras Stankevičius, Aistė Jekabsone
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:International Journal of Molecular Sciences
Subjects:
COVID-19
mitochondrial network
cristae
STED microscopy
mitochondrial superoxide
ROS
Online Access:https://www.mdpi.com/1422-0067/25/6/3188

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