Medical-Grade Honey as an Alternative Treatment for Antibiotics in Non-Healing Wounds—A Prospective Case Series
Non-healing wounds are usually colonised by various types of bacteria. An alternative to antibiotic treatment in patients with infected wounds with local signs of inflammation may be medical-grade honey (MGH), which favourably affects the healing process with its antimicrobial, antioxidant, anti-inf...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Antibiotics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6382/10/8/918 |
| _version_ | 1797524939156226048 |
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| author | Adéla Holubová Lucie Chlupáčová Lada Cetlová Niels A. J. Cremers Andrea Pokorná |
| author_facet | Adéla Holubová Lucie Chlupáčová Lada Cetlová Niels A. J. Cremers Andrea Pokorná |
| author_sort | Adéla Holubová |
| collection | DOAJ |
| description | Non-healing wounds are usually colonised by various types of bacteria. An alternative to antibiotic treatment in patients with infected wounds with local signs of inflammation may be medical-grade honey (MGH), which favourably affects the healing process with its antimicrobial, antioxidant, anti-inflammatory, and immunomodulatory properties. The objective of this study was to evaluate the effect of MGH therapy on the healing process of non-healing wounds of various aetiologies and different wound colonisations. Prospective, observation–intervention case studies (<i>n</i> = 9) of patients with wounds of various aetiologies (venous leg ulcers, diabetic foot ulcers, surgical wound dehiscence) are presented. All wounds were treated with MGH and the healing trajectory was rigorously and objectively monitored. In all cases, pain, odour, and exudation were quickly resolved, which led to an improvement in the quality of life of patients. Despite the proven bacterial microflora in wounds, antibiotic treatment was not necessary. The effects of MGH alleviated the signs of local infection until their complete elimination. In eight out of nine cases, the non-healing wound was completely healed. MGH has antimicrobial, anti-inflammatory, and antioxidant effects in wounds of various aetiologies and forms an effective alternative for the use of antibiotics for treating locally infected wounds. |
| first_indexed | 2024-03-10T09:04:45Z |
| format | Article |
| id | doaj.art-d50fc88e99364c9c9a515b2a6ce2271c |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T09:04:45Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-d50fc88e99364c9c9a515b2a6ce2271c2023-11-22T06:33:14ZengMDPI AGAntibiotics2079-63822021-07-0110891810.3390/antibiotics10080918Medical-Grade Honey as an Alternative Treatment for Antibiotics in Non-Healing Wounds—A Prospective Case SeriesAdéla Holubová0Lucie Chlupáčová1Lada Cetlová2Niels A. J. Cremers3Andrea Pokorná4Faculty of Health and Social Sciences, University of Bohemia, 370 11 České Budějovice, Czech RepublicDiaPodi Care spol. s r.o., 392 01 Soběslav, Czech RepublicDepartment of Health Sciences, College of Polytechnics Jihlava, 586 01 Jihlava, Czech RepublicTriticum Exploitatie BV, 6222 NK Maastricht, The NetherlandsDepartment of Health Sciences, College of Polytechnics Jihlava, 586 01 Jihlava, Czech RepublicNon-healing wounds are usually colonised by various types of bacteria. An alternative to antibiotic treatment in patients with infected wounds with local signs of inflammation may be medical-grade honey (MGH), which favourably affects the healing process with its antimicrobial, antioxidant, anti-inflammatory, and immunomodulatory properties. The objective of this study was to evaluate the effect of MGH therapy on the healing process of non-healing wounds of various aetiologies and different wound colonisations. Prospective, observation–intervention case studies (<i>n</i> = 9) of patients with wounds of various aetiologies (venous leg ulcers, diabetic foot ulcers, surgical wound dehiscence) are presented. All wounds were treated with MGH and the healing trajectory was rigorously and objectively monitored. In all cases, pain, odour, and exudation were quickly resolved, which led to an improvement in the quality of life of patients. Despite the proven bacterial microflora in wounds, antibiotic treatment was not necessary. The effects of MGH alleviated the signs of local infection until their complete elimination. In eight out of nine cases, the non-healing wound was completely healed. MGH has antimicrobial, anti-inflammatory, and antioxidant effects in wounds of various aetiologies and forms an effective alternative for the use of antibiotics for treating locally infected wounds.https://www.mdpi.com/2079-6382/10/8/918medical grade honeyantibiotic replacementinfectionswoundsobjective wound assessment |
| spellingShingle | Adéla Holubová Lucie Chlupáčová Lada Cetlová Niels A. J. Cremers Andrea Pokorná Medical-Grade Honey as an Alternative Treatment for Antibiotics in Non-Healing Wounds—A Prospective Case Series Antibiotics medical grade honey antibiotic replacement infections wounds objective wound assessment |
| title | Medical-Grade Honey as an Alternative Treatment for Antibiotics in Non-Healing Wounds—A Prospective Case Series |
| title_full | Medical-Grade Honey as an Alternative Treatment for Antibiotics in Non-Healing Wounds—A Prospective Case Series |
| title_fullStr | Medical-Grade Honey as an Alternative Treatment for Antibiotics in Non-Healing Wounds—A Prospective Case Series |
| title_full_unstemmed | Medical-Grade Honey as an Alternative Treatment for Antibiotics in Non-Healing Wounds—A Prospective Case Series |
| title_short | Medical-Grade Honey as an Alternative Treatment for Antibiotics in Non-Healing Wounds—A Prospective Case Series |
| title_sort | medical grade honey as an alternative treatment for antibiotics in non healing wounds a prospective case series |
| topic | medical grade honey antibiotic replacement infections wounds objective wound assessment |
| url | https://www.mdpi.com/2079-6382/10/8/918 |
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