Therapeutic Hypothermia: Critical review of the molecular mechanisms of action.
Therapeutic Hypothermia (TH) is nowadays one of the most important methods of neuroprotection. The events that occur after an episode of ischemia are multiple and hypothermia can affect the various steps of this cascade. The mechanisms of action of TH are varied and the possible explanation for the...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2011-02-01
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| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fneur.2011.00004/full |
| _version_ | 1818384845338836992 |
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| author | Fernando Pavel Gonzalez-Ibarra Joseph eVaron Elmer G Lopez-Meza |
| author_facet | Fernando Pavel Gonzalez-Ibarra Joseph eVaron Elmer G Lopez-Meza |
| author_sort | Fernando Pavel Gonzalez-Ibarra |
| collection | DOAJ |
| description | Therapeutic Hypothermia (TH) is nowadays one of the most important methods of neuroprotection. The events that occur after an episode of ischemia are multiple and hypothermia can affect the various steps of this cascade. The mechanisms of action of TH are varied and the possible explanation for the benefits of this therapy is probably the multiple mechanisms of action blocking the cascade of ischemia on many levels. TH can affect many metabolic pathways, reactions of inflammation, apoptosis processes and promote neuronal integrity. To know the mechanisms of action of TH will allow a better understanding about the indications for this therapy and the possibility of searching for other therapies when used in conjunction with hypothermia will provide a therapeutic synergistic effect. |
| first_indexed | 2024-12-14T03:28:44Z |
| format | Article |
| id | doaj.art-d50fefd4121f487bb34cba1d1b50dca6 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-14T03:28:44Z |
| publishDate | 2011-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-d50fefd4121f487bb34cba1d1b50dca62022-12-21T23:18:49ZengFrontiers Media S.A.Frontiers in Neurology1664-22952011-02-01210.3389/fneur.2011.000042049Therapeutic Hypothermia: Critical review of the molecular mechanisms of action.Fernando Pavel Gonzalez-Ibarra0Joseph eVaron1Elmer G Lopez-Meza2Culiacan General HospitalThe University of Texas Health Science Center at Houston Culiacan General HospitalTherapeutic Hypothermia (TH) is nowadays one of the most important methods of neuroprotection. The events that occur after an episode of ischemia are multiple and hypothermia can affect the various steps of this cascade. The mechanisms of action of TH are varied and the possible explanation for the benefits of this therapy is probably the multiple mechanisms of action blocking the cascade of ischemia on many levels. TH can affect many metabolic pathways, reactions of inflammation, apoptosis processes and promote neuronal integrity. To know the mechanisms of action of TH will allow a better understanding about the indications for this therapy and the possibility of searching for other therapies when used in conjunction with hypothermia will provide a therapeutic synergistic effect.http://journal.frontiersin.org/Journal/10.3389/fneur.2011.00004/fullcerebral ischemiamechanism of actionNeuronal Deathexcitatory neurotransmitersneuronal acidosisTherapeutic hypothermia |
| spellingShingle | Fernando Pavel Gonzalez-Ibarra Joseph eVaron Elmer G Lopez-Meza Therapeutic Hypothermia: Critical review of the molecular mechanisms of action. Frontiers in Neurology cerebral ischemia mechanism of action Neuronal Death excitatory neurotransmiters neuronal acidosis Therapeutic hypothermia |
| title | Therapeutic Hypothermia: Critical review of the molecular mechanisms of action. |
| title_full | Therapeutic Hypothermia: Critical review of the molecular mechanisms of action. |
| title_fullStr | Therapeutic Hypothermia: Critical review of the molecular mechanisms of action. |
| title_full_unstemmed | Therapeutic Hypothermia: Critical review of the molecular mechanisms of action. |
| title_short | Therapeutic Hypothermia: Critical review of the molecular mechanisms of action. |
| title_sort | therapeutic hypothermia critical review of the molecular mechanisms of action |
| topic | cerebral ischemia mechanism of action Neuronal Death excitatory neurotransmiters neuronal acidosis Therapeutic hypothermia |
| url | http://journal.frontiersin.org/Journal/10.3389/fneur.2011.00004/full |
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