Association between the homeostasis model assessment of insulin resistance and coronary artery calcification: a meta-analysis of observational studies
BackgroundInsulin resistance (IR), a risk factor for cardiovascular diseases, has garnered significant attention in scientific research. Several studies have investigated the correlation between IR and coronary artery calcification (CAC), yielding varying results. In light of this, we conducted a sy...
| Main Authors: | , , , , , |
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| Format: | Article |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1271857/full |
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| author | Longti Li Huiqin Zhong Ya Shao Yu Hua Xu Zhou Desheng Luo |
| author_facet | Longti Li Huiqin Zhong Ya Shao Yu Hua Xu Zhou Desheng Luo |
| author_sort | Longti Li |
| collection | DOAJ |
| description | BackgroundInsulin resistance (IR), a risk factor for cardiovascular diseases, has garnered significant attention in scientific research. Several studies have investigated the correlation between IR and coronary artery calcification (CAC), yielding varying results. In light of this, we conducted a systematic review to investigate the association between IR as evaluated by the homeostasis model assessment (HOMA-IR) and CAC.MethodsA comprehensive search was conducted to identify relevant studies in PubMed, Embase, Scopus, and Web of Science databases. In addition, preprint servers such as Research Square, BioRxiv, and MedRxiv were manually searched. The collected data were analyzed using either fixed or random effects models, depending on the heterogeneity observed among the studies. The assessment of the body of evidence was performed using the GRADE approach to determine its quality.ResultsThe current research incorporated 15 studies with 60,649 subjects. The analysis revealed that a higher category of HOMA-IR was associated with a greater prevalence of CAC in comparison to the lowest HOMA-IR category, with an OR of 1.13 (95% CI: 1.06–1.20, I2 = 29%, P < 0.001). A similar result was reached when HOMA-IR was analyzed as a continuous variable (OR: 1.27, 95% CI: 1.14–1.41, I2 = 54%, P < 0.001). In terms of CAC progression, a pooled analysis of two cohort studies disclosed a significant association between increased HOMA-IR levels and CAC progression, with an OR of 1.44 (95% CI: 1.04–2.01, I2 = 21%, P < 0.05). It is important to note that the strength of the evidence was rated as low for the prevalence of CAC and very low for the progression of CAC.ConclusionThere is evidence to suggest that a relatively high HOMA-IR may be linked with an increased prevalence and progression of CAC. |
| first_indexed | 2024-03-09T14:44:53Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-09T14:44:53Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-d5118c44d038409aaa946f0aa49ada162023-11-27T10:27:55ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-11-011410.3389/fendo.2023.12718571271857Association between the homeostasis model assessment of insulin resistance and coronary artery calcification: a meta-analysis of observational studiesLongti Li0Huiqin Zhong1Ya Shao2Yu Hua3Xu Zhou4Desheng Luo5Department of Nursing, TaiHe Hospital, Hubei University of Medicine, Shiyan, ChinaInnovation Centre of Nursing Research, TaiHe Hospital, Hubei University of Medicine, Shiyan, ChinaHealth Management Center, TaiHe Hospital, Hubei University of Medicine, Shiyan, ChinaHealth Management Center, TaiHe Hospital, Hubei University of Medicine, Shiyan, ChinaHealth Management Center, TaiHe Hospital, Hubei University of Medicine, Shiyan, ChinaDepartment of Nursing, TaiHe Hospital, Hubei University of Medicine, Shiyan, ChinaBackgroundInsulin resistance (IR), a risk factor for cardiovascular diseases, has garnered significant attention in scientific research. Several studies have investigated the correlation between IR and coronary artery calcification (CAC), yielding varying results. In light of this, we conducted a systematic review to investigate the association between IR as evaluated by the homeostasis model assessment (HOMA-IR) and CAC.MethodsA comprehensive search was conducted to identify relevant studies in PubMed, Embase, Scopus, and Web of Science databases. In addition, preprint servers such as Research Square, BioRxiv, and MedRxiv were manually searched. The collected data were analyzed using either fixed or random effects models, depending on the heterogeneity observed among the studies. The assessment of the body of evidence was performed using the GRADE approach to determine its quality.ResultsThe current research incorporated 15 studies with 60,649 subjects. The analysis revealed that a higher category of HOMA-IR was associated with a greater prevalence of CAC in comparison to the lowest HOMA-IR category, with an OR of 1.13 (95% CI: 1.06–1.20, I2 = 29%, P < 0.001). A similar result was reached when HOMA-IR was analyzed as a continuous variable (OR: 1.27, 95% CI: 1.14–1.41, I2 = 54%, P < 0.001). In terms of CAC progression, a pooled analysis of two cohort studies disclosed a significant association between increased HOMA-IR levels and CAC progression, with an OR of 1.44 (95% CI: 1.04–2.01, I2 = 21%, P < 0.05). It is important to note that the strength of the evidence was rated as low for the prevalence of CAC and very low for the progression of CAC.ConclusionThere is evidence to suggest that a relatively high HOMA-IR may be linked with an increased prevalence and progression of CAC.https://www.frontiersin.org/articles/10.3389/fendo.2023.1271857/fullinsulin resistancehomeostasis model assessmentHOMA-IRcoronary artery calcificationCACmeta-analysis |
| spellingShingle | Longti Li Huiqin Zhong Ya Shao Yu Hua Xu Zhou Desheng Luo Association between the homeostasis model assessment of insulin resistance and coronary artery calcification: a meta-analysis of observational studies Frontiers in Endocrinology insulin resistance homeostasis model assessment HOMA-IR coronary artery calcification CAC meta-analysis |
| title | Association between the homeostasis model assessment of insulin resistance and coronary artery calcification: a meta-analysis of observational studies |
| title_full | Association between the homeostasis model assessment of insulin resistance and coronary artery calcification: a meta-analysis of observational studies |
| title_fullStr | Association between the homeostasis model assessment of insulin resistance and coronary artery calcification: a meta-analysis of observational studies |
| title_full_unstemmed | Association between the homeostasis model assessment of insulin resistance and coronary artery calcification: a meta-analysis of observational studies |
| title_short | Association between the homeostasis model assessment of insulin resistance and coronary artery calcification: a meta-analysis of observational studies |
| title_sort | association between the homeostasis model assessment of insulin resistance and coronary artery calcification a meta analysis of observational studies |
| topic | insulin resistance homeostasis model assessment HOMA-IR coronary artery calcification CAC meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1271857/full |
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