Potent inhibitory effect of Hizikia fusiformis cold water extract on human macrophages and mouse colon inflammatory responses
Obtaining extracts rich in pharmacological components from edible brown seaweeds is essential for their use as functional foods or therapeutic supplements. The present study demonstrated that the cold-water extract of Hizikia fusiformis (HF-C) with a unique composition, unlike hot-water (HF-H) or ac...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-10-01
|
| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S175646462300395X |
| _version_ | 1797660405852536832 |
|---|---|
| author | Prakash Chaudhary Seung Joo Kim Sadan Dahal Shambhu Joshi Sung Bum Son Soo Young Kim Sung-Hwan Eom Kyung Tae Kim Jung-Ae Kim |
| author_facet | Prakash Chaudhary Seung Joo Kim Sadan Dahal Shambhu Joshi Sung Bum Son Soo Young Kim Sung-Hwan Eom Kyung Tae Kim Jung-Ae Kim |
| author_sort | Prakash Chaudhary |
| collection | DOAJ |
| description | Obtaining extracts rich in pharmacological components from edible brown seaweeds is essential for their use as functional foods or therapeutic supplements. The present study demonstrated that the cold-water extract of Hizikia fusiformis (HF-C) with a unique composition, unlike hot-water (HF-H) or acid (HF-A) extracts, inhibited NF-κB activation, pro-inflammatory cytokines and glucose transporter expression, and inflammatory glycolysis more than HF-H or HF-A did. Oral administration of HF-C significantly inhibited dextran sodium sulfate-induced colitis in mouse, as evidenced by a decrease in disease activity index and inflammatory cytokine expression, and recovered colonic tissue E-cadherin expression and body weight. Notably, the anti-colitis effect of HF-C was greater than sulfasalazine, an inflammatory bowel disease (IBD) drug. Taken together, the higher anti-inflammatory action of HF-C was due to the different composition of fucoidan compared to the other extracts. Consequently, the results suggest that HF-C may be a therapeutic adjunct to the treatment of IBD. |
| first_indexed | 2024-03-11T18:29:20Z |
| format | Article |
| id | doaj.art-d512b2492a2842f79c6b25eb7dfd4b70 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-03-11T18:29:20Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-d512b2492a2842f79c6b25eb7dfd4b702023-10-13T13:52:53ZengElsevierJournal of Functional Foods1756-46462023-10-01109105795Potent inhibitory effect of Hizikia fusiformis cold water extract on human macrophages and mouse colon inflammatory responsesPrakash Chaudhary0Seung Joo Kim1Sadan Dahal2Shambhu Joshi3Sung Bum Son4Soo Young Kim5Sung-Hwan Eom6Kyung Tae Kim7Jung-Ae Kim8College of Pharmacy and Institute for Drug Research, Yeungnam University, Gyeongsan 38541, Republic of KoreaCollege of Pharmacy and Institute for Drug Research, Yeungnam University, Gyeongsan 38541, Republic of KoreaCollege of Pharmacy and Institute for Drug Research, Yeungnam University, Gyeongsan 38541, Republic of KoreaCollege of Pharmacy and Institute for Drug Research, Yeungnam University, Gyeongsan 38541, Republic of KoreaDepartment of Food Science and Technology, College of Engineering, Dong-Eui University, Busan 47340, Republic of KoreaCollege of Pharmacy and Institute for Drug Research, Yeungnam University, Gyeongsan 38541, Republic of KoreaDepartment of Food Science and Technology, College of Engineering, Dong-Eui University, Busan 47340, Republic of KoreaDepartment of Food Science and Technology, College of Engineering, Dong-Eui University, Busan 47340, Republic of Korea; Corresponding authors.College of Pharmacy and Institute for Drug Research, Yeungnam University, Gyeongsan 38541, Republic of Korea; Corresponding authors.Obtaining extracts rich in pharmacological components from edible brown seaweeds is essential for their use as functional foods or therapeutic supplements. The present study demonstrated that the cold-water extract of Hizikia fusiformis (HF-C) with a unique composition, unlike hot-water (HF-H) or acid (HF-A) extracts, inhibited NF-κB activation, pro-inflammatory cytokines and glucose transporter expression, and inflammatory glycolysis more than HF-H or HF-A did. Oral administration of HF-C significantly inhibited dextran sodium sulfate-induced colitis in mouse, as evidenced by a decrease in disease activity index and inflammatory cytokine expression, and recovered colonic tissue E-cadherin expression and body weight. Notably, the anti-colitis effect of HF-C was greater than sulfasalazine, an inflammatory bowel disease (IBD) drug. Taken together, the higher anti-inflammatory action of HF-C was due to the different composition of fucoidan compared to the other extracts. Consequently, the results suggest that HF-C may be a therapeutic adjunct to the treatment of IBD.http://www.sciencedirect.com/science/article/pii/S175646462300395XCold-water extractionHizikia fusiformisFucoidanArabinoseGLUT1Inflammatory macrophage |
| spellingShingle | Prakash Chaudhary Seung Joo Kim Sadan Dahal Shambhu Joshi Sung Bum Son Soo Young Kim Sung-Hwan Eom Kyung Tae Kim Jung-Ae Kim Potent inhibitory effect of Hizikia fusiformis cold water extract on human macrophages and mouse colon inflammatory responses Journal of Functional Foods Cold-water extraction Hizikia fusiformis Fucoidan Arabinose GLUT1 Inflammatory macrophage |
| title | Potent inhibitory effect of Hizikia fusiformis cold water extract on human macrophages and mouse colon inflammatory responses |
| title_full | Potent inhibitory effect of Hizikia fusiformis cold water extract on human macrophages and mouse colon inflammatory responses |
| title_fullStr | Potent inhibitory effect of Hizikia fusiformis cold water extract on human macrophages and mouse colon inflammatory responses |
| title_full_unstemmed | Potent inhibitory effect of Hizikia fusiformis cold water extract on human macrophages and mouse colon inflammatory responses |
| title_short | Potent inhibitory effect of Hizikia fusiformis cold water extract on human macrophages and mouse colon inflammatory responses |
| title_sort | potent inhibitory effect of hizikia fusiformis cold water extract on human macrophages and mouse colon inflammatory responses |
| topic | Cold-water extraction Hizikia fusiformis Fucoidan Arabinose GLUT1 Inflammatory macrophage |
| url | http://www.sciencedirect.com/science/article/pii/S175646462300395X |
| work_keys_str_mv | AT prakashchaudhary potentinhibitoryeffectofhizikiafusiformiscoldwaterextractonhumanmacrophagesandmousecoloninflammatoryresponses AT seungjookim potentinhibitoryeffectofhizikiafusiformiscoldwaterextractonhumanmacrophagesandmousecoloninflammatoryresponses AT sadandahal potentinhibitoryeffectofhizikiafusiformiscoldwaterextractonhumanmacrophagesandmousecoloninflammatoryresponses AT shambhujoshi potentinhibitoryeffectofhizikiafusiformiscoldwaterextractonhumanmacrophagesandmousecoloninflammatoryresponses AT sungbumson potentinhibitoryeffectofhizikiafusiformiscoldwaterextractonhumanmacrophagesandmousecoloninflammatoryresponses AT sooyoungkim potentinhibitoryeffectofhizikiafusiformiscoldwaterextractonhumanmacrophagesandmousecoloninflammatoryresponses AT sunghwaneom potentinhibitoryeffectofhizikiafusiformiscoldwaterextractonhumanmacrophagesandmousecoloninflammatoryresponses AT kyungtaekim potentinhibitoryeffectofhizikiafusiformiscoldwaterextractonhumanmacrophagesandmousecoloninflammatoryresponses AT jungaekim potentinhibitoryeffectofhizikiafusiformiscoldwaterextractonhumanmacrophagesandmousecoloninflammatoryresponses |