PEROXYSOME PROLIFERATOR-ACTIVATED RECEPTORS AND THEIR COACTIVATOR — PGC-1α — IN PHYSIOLOGY AND PATHOLOGY OF MYOCARDIUM
The receptors, activated by peroxysome proliferators (PPAR) α and β/δ do rule the gene expression of fatty acids (FA), that are the source of 70-90% ATP in myocardium. PPAR α controls FA oxydation and influences myocardial energy metabolism homeostasis, mostly through the supplement of circulating F...
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| Format: | Article |
| Language: | Russian |
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«FIRMA «SILICEA» LLC
2014-11-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/156 |
| Summary: | The receptors, activated by peroxysome proliferators (PPAR) α and β/δ do rule the gene expression of fatty acids (FA), that are the source of 70-90% ATP in myocardium. PPAR α controls FA oxydation and influences myocardial energy metabolism homeostasis, mostly through the supplement of circulating FA from the liver, and PPARγ prevent the excess of FA in myocardium with lipotoxicity prevented by switching the flow of FA to adipocytes. PPARβ/δ is the main regulator of lipid metabolism on muscles, that are 50% of body mass. The PPAR/PGC-1α system (mostly PPARα/PGC-1α) controls the biogenesis of mitochondria and hence makes available the possibility to adaptate myocardium for sudden (stress) exertion. Expression of PPARα/PGC-1α increases in physiologic forms of myocardial hypertrophy: in postnatal period and physical entraining, and decreases in pathological forms of myocardial hypertrophy and heart failure. Dysfunction of regulatory system PPAR/ PGC-1α might be one of the pathogenetic mechanisms of cardiomyopathy development, and signal pathways for the system the object for therapeutic interventions. |
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| ISSN: | 1560-4071 2618-7620 |