Recent Progress on the Synthesis of Bipyridine Derivatives
Bipyridine and related compounds are starting materials or precursors for a variety of valuable substances such as biologically active molecules, ligands for catalysts, photosensitizers, viologens, and supramolecular architectures. Thus, it is important to classify their synthesis methods and unders...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/29/3/576 |
| _version_ | 1797318486044704768 |
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| author | Yoshinori Yamanoi |
| author_facet | Yoshinori Yamanoi |
| author_sort | Yoshinori Yamanoi |
| collection | DOAJ |
| description | Bipyridine and related compounds are starting materials or precursors for a variety of valuable substances such as biologically active molecules, ligands for catalysts, photosensitizers, viologens, and supramolecular architectures. Thus, it is important to classify their synthesis methods and understand their characteristics. Representative examples include methods using homo and heterocoupling of pyridine derivatives in the presence of a catalyst. Because bipyridine compounds strongly coordinate with metal centers, a decrease in catalytic activity and yield is often observed in the reaction system. To address this issue, this review provides insights into advances over the last ~30 years in bipyridine synthesis using metal complexes under both homogeneous and heterogeneous conditions. Moreover, strategies for bipyridine synthesis involving sulfur and phosphorous compounds are examined. These alternative pathways offer promising avenues for overcoming the challenges associated with traditional catalysis methods, providing a more comprehensive understanding of the synthesis landscape. |
| first_indexed | 2024-03-08T03:53:06Z |
| format | Article |
| id | doaj.art-d51420e97b454380846ce16b0239e778 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-08T03:53:06Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-d51420e97b454380846ce16b0239e7782024-02-09T15:18:40ZengMDPI AGMolecules1420-30492024-01-0129357610.3390/molecules29030576Recent Progress on the Synthesis of Bipyridine DerivativesYoshinori Yamanoi0Department of Chemistry, School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, JapanBipyridine and related compounds are starting materials or precursors for a variety of valuable substances such as biologically active molecules, ligands for catalysts, photosensitizers, viologens, and supramolecular architectures. Thus, it is important to classify their synthesis methods and understand their characteristics. Representative examples include methods using homo and heterocoupling of pyridine derivatives in the presence of a catalyst. Because bipyridine compounds strongly coordinate with metal centers, a decrease in catalytic activity and yield is often observed in the reaction system. To address this issue, this review provides insights into advances over the last ~30 years in bipyridine synthesis using metal complexes under both homogeneous and heterogeneous conditions. Moreover, strategies for bipyridine synthesis involving sulfur and phosphorous compounds are examined. These alternative pathways offer promising avenues for overcoming the challenges associated with traditional catalysis methods, providing a more comprehensive understanding of the synthesis landscape.https://www.mdpi.com/1420-3049/29/3/576Suzuki couplingStille couplingNegishi couplingUllmann couplingWurtz couplingelectrochemical method |
| spellingShingle | Yoshinori Yamanoi Recent Progress on the Synthesis of Bipyridine Derivatives Molecules Suzuki coupling Stille coupling Negishi coupling Ullmann coupling Wurtz coupling electrochemical method |
| title | Recent Progress on the Synthesis of Bipyridine Derivatives |
| title_full | Recent Progress on the Synthesis of Bipyridine Derivatives |
| title_fullStr | Recent Progress on the Synthesis of Bipyridine Derivatives |
| title_full_unstemmed | Recent Progress on the Synthesis of Bipyridine Derivatives |
| title_short | Recent Progress on the Synthesis of Bipyridine Derivatives |
| title_sort | recent progress on the synthesis of bipyridine derivatives |
| topic | Suzuki coupling Stille coupling Negishi coupling Ullmann coupling Wurtz coupling electrochemical method |
| url | https://www.mdpi.com/1420-3049/29/3/576 |
| work_keys_str_mv | AT yoshinoriyamanoi recentprogressonthesynthesisofbipyridinederivatives |