Analysis of lamb lung development with tracheal ligation in left posterolateral diaphragmatic hernia in cases and controls
BACKGROUND: When we perform surgery in utero, lungs have an appropriate time to decrease magnitude of hypoplasia, with surgery in uterus. METHODS: Six time-dated single-fetus ewes were selected to induce diaphragmatic hernia. Fetal lambs were divided proportionally into 2 groups, namely gro...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2006-12-01
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| Series: | Journal of Research in Medical Sciences |
| Subjects: | |
| Online Access: | http://journals.mui.ac.ir/jrms/article/view/119 |
| _version_ | 1818065429647589376 |
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| author | Mahmoud Ashrafi Masoud Jamshidi Mahdi Fareed Mohmmad Hosein Sanei |
| author_facet | Mahmoud Ashrafi Masoud Jamshidi Mahdi Fareed Mohmmad Hosein Sanei |
| author_sort | Mahmoud Ashrafi |
| collection | DOAJ |
| description | BACKGROUND: When we perform surgery in utero, lungs have an appropriate time to decrease magnitude of hypoplasia, with surgery in uterus. METHODS: Six time-dated single-fetus ewes were selected to induce diaphragmatic hernia. Fetal lambs were divided proportionally into 2 groups, namely group 1, diaphragmatic hernia and tracheal ligation (TL group), and group 2, diaphragmatic hernia only (NL group). Morphologic assessments (weight, volume, bronchiolar branching) and histological tests (lung maturation phase) were performed. RESULTS: Lung weight in relation to lamb weight in the tracheal ligation group differed significantly from the control group (P<0.006 in the right lung and P<0.005 in the left lung). Other parameters were markedly different between the two groups. Lung volumes in relation to lamb weight were 29.88 ± 12.54 in the tracheal ligated group [TL] and 6.44 ± 1.84 in the non-ligated [NL] group in the right lung and 21.52 ± 7.58 in the TL group and 3.86 ± 1.90 in the NL group in the left lung. All parameters were in favor of tracheal ligation. Lung maturation phase arrested in the canalicular phase in the NL group and continued to the saccular phase in the TL group. CONCLUSIONS: Tracheal ligation resulted in more mature lungs in the TL group. KEY WORDS: Congenital diaphragmatic hernia, tracheal ligation, sheep, lamb, fetal surgery. |
| first_indexed | 2024-12-10T14:51:45Z |
| format | Article |
| id | doaj.art-d516b9ebe63a4376b2c96afd2d661784 |
| institution | Directory Open Access Journal |
| issn | 1735-1995 1735-7136 |
| language | English |
| last_indexed | 2024-12-10T14:51:45Z |
| publishDate | 2006-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Research in Medical Sciences |
| spelling | doaj.art-d516b9ebe63a4376b2c96afd2d6617842022-12-22T01:44:25ZengWolters Kluwer Medknow PublicationsJournal of Research in Medical Sciences1735-19951735-71362006-12-01115319324Analysis of lamb lung development with tracheal ligation in left posterolateral diaphragmatic hernia in cases and controlsMahmoud AshrafiMasoud JamshidiMahdi FareedMohmmad Hosein SaneiBACKGROUND: When we perform surgery in utero, lungs have an appropriate time to decrease magnitude of hypoplasia, with surgery in uterus. METHODS: Six time-dated single-fetus ewes were selected to induce diaphragmatic hernia. Fetal lambs were divided proportionally into 2 groups, namely group 1, diaphragmatic hernia and tracheal ligation (TL group), and group 2, diaphragmatic hernia only (NL group). Morphologic assessments (weight, volume, bronchiolar branching) and histological tests (lung maturation phase) were performed. RESULTS: Lung weight in relation to lamb weight in the tracheal ligation group differed significantly from the control group (P<0.006 in the right lung and P<0.005 in the left lung). Other parameters were markedly different between the two groups. Lung volumes in relation to lamb weight were 29.88 ± 12.54 in the tracheal ligated group [TL] and 6.44 ± 1.84 in the non-ligated [NL] group in the right lung and 21.52 ± 7.58 in the TL group and 3.86 ± 1.90 in the NL group in the left lung. All parameters were in favor of tracheal ligation. Lung maturation phase arrested in the canalicular phase in the NL group and continued to the saccular phase in the TL group. CONCLUSIONS: Tracheal ligation resulted in more mature lungs in the TL group. KEY WORDS: Congenital diaphragmatic hernia, tracheal ligation, sheep, lamb, fetal surgery.http://journals.mui.ac.ir/jrms/article/view/119Congenital diaphragmatic hernia, tracheal ligation, sheep, lamb, fetal surgery. |
| spellingShingle | Mahmoud Ashrafi Masoud Jamshidi Mahdi Fareed Mohmmad Hosein Sanei Analysis of lamb lung development with tracheal ligation in left posterolateral diaphragmatic hernia in cases and controls Journal of Research in Medical Sciences Congenital diaphragmatic hernia, tracheal ligation, sheep, lamb, fetal surgery. |
| title | Analysis of lamb lung development with tracheal ligation in left posterolateral diaphragmatic hernia in cases and controls |
| title_full | Analysis of lamb lung development with tracheal ligation in left posterolateral diaphragmatic hernia in cases and controls |
| title_fullStr | Analysis of lamb lung development with tracheal ligation in left posterolateral diaphragmatic hernia in cases and controls |
| title_full_unstemmed | Analysis of lamb lung development with tracheal ligation in left posterolateral diaphragmatic hernia in cases and controls |
| title_short | Analysis of lamb lung development with tracheal ligation in left posterolateral diaphragmatic hernia in cases and controls |
| title_sort | analysis of lamb lung development with tracheal ligation in left posterolateral diaphragmatic hernia in cases and controls |
| topic | Congenital diaphragmatic hernia, tracheal ligation, sheep, lamb, fetal surgery. |
| url | http://journals.mui.ac.ir/jrms/article/view/119 |
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