Late running is not too late against Alzheimer's pathology
In the last decade a vast number of animal studies have produced overwhelming evidence that exercise not only compensates for memory loss by increasing brain plasticity and cognitive reserve but also directly counteracts Alzheimer-like pathology when provided before disease onset or in early disease...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016-10-01
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| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S096999611630136X |
| _version_ | 1818742110674747392 |
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| author | Arne Herring Yvonne Münster Judith Metzdorf Bastien Bolczek Sarah Krüssel David Krieter Ilkay Yavuz Fro Karim Constanze Roggendorf Anthony Stang Yachao Wang Dirk M. Hermann Sarah Teuber-Hanselmann Kathy Keyvani |
| author_facet | Arne Herring Yvonne Münster Judith Metzdorf Bastien Bolczek Sarah Krüssel David Krieter Ilkay Yavuz Fro Karim Constanze Roggendorf Anthony Stang Yachao Wang Dirk M. Hermann Sarah Teuber-Hanselmann Kathy Keyvani |
| author_sort | Arne Herring |
| collection | DOAJ |
| description | In the last decade a vast number of animal studies have produced overwhelming evidence that exercise not only compensates for memory loss by increasing brain plasticity and cognitive reserve but also directly counteracts Alzheimer-like pathology when provided before disease onset or in early disease stages. But so far, there is little knowledge about therapeutic effects of training when started in advanced disease stages. In the present study we show that following seven months of sedentary life style five months of wheel running, started four months after disease onset was still able to mitigate at least some aspects of the full-blown Alzheimer's pathology in TgCRND8 mice. Late running had mild but significant effects on structural plasticity by increasing the dendritic complexity. It further reduced beta-amyloid (Aβ) plaque burden and enhanced Aβ clearance across the blood-brain barrier, along with attenuating microgliosis, inflammation, oxidative stress, and autophagy deficits, resulting in better memory performance and less agitation. However, unlike early exercise, late running did not affect abnormal amyloid precursor protein metabolism, tau pathology, or angiogenesis. These results allow concluding that it is never too late to counteract Alzheimer's disease with physical training but the earlier the intervention starts, the more pronounced is the therapeutic potential. |
| first_indexed | 2024-12-18T02:07:19Z |
| format | Article |
| id | doaj.art-d519ced07e8b45b3848009bb2ba55546 |
| institution | Directory Open Access Journal |
| issn | 1095-953X |
| language | English |
| last_indexed | 2024-12-18T02:07:19Z |
| publishDate | 2016-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Disease |
| spelling | doaj.art-d519ced07e8b45b3848009bb2ba555462022-12-21T21:24:34ZengElsevierNeurobiology of Disease1095-953X2016-10-01944454Late running is not too late against Alzheimer's pathologyArne Herring0Yvonne Münster1Judith Metzdorf2Bastien Bolczek3Sarah Krüssel4David Krieter5Ilkay Yavuz6Fro Karim7Constanze Roggendorf8Anthony Stang9Yachao Wang10Dirk M. Hermann11Sarah Teuber-Hanselmann12Kathy Keyvani13Institute of Neuropathology, University of Duisburg-Essen, Hufelandstr. 55, 45122 Essen, Germany; Corresponding author.Institute of Neuropathology, University of Duisburg-Essen, Hufelandstr. 55, 45122 Essen, GermanyInstitute of Neuropathology, University of Duisburg-Essen, Hufelandstr. 55, 45122 Essen, GermanyInstitute of Neuropathology, University of Duisburg-Essen, Hufelandstr. 55, 45122 Essen, GermanyInstitute of Neuropathology, University of Duisburg-Essen, Hufelandstr. 55, 45122 Essen, GermanyInstitute of Neuropathology, University of Duisburg-Essen, Hufelandstr. 55, 45122 Essen, GermanyInstitute of Neuropathology, University of Duisburg-Essen, Hufelandstr. 55, 45122 Essen, GermanyInstitute of Neuropathology, University of Duisburg-Essen, Hufelandstr. 55, 45122 Essen, GermanyInstitute of Neuropathology, University of Duisburg-Essen, Hufelandstr. 55, 45122 Essen, GermanyInstitute of Neuropathology, University of Duisburg-Essen, Hufelandstr. 55, 45122 Essen, GermanyDepartment of Neurology, University of Duisburg-Essen, Hufelandstr. 55, 45122 Essen, GermanyDepartment of Neurology, University of Duisburg-Essen, Hufelandstr. 55, 45122 Essen, GermanyInstitute of Neuropathology, University of Duisburg-Essen, Hufelandstr. 55, 45122 Essen, GermanyInstitute of Neuropathology, University of Duisburg-Essen, Hufelandstr. 55, 45122 Essen, Germany; Correspondence to: K. Keyvani, Institute of Neuropathology, University of Duisburg-Essen, Hufelandstr. 55, 45122 Essen, Germany.In the last decade a vast number of animal studies have produced overwhelming evidence that exercise not only compensates for memory loss by increasing brain plasticity and cognitive reserve but also directly counteracts Alzheimer-like pathology when provided before disease onset or in early disease stages. But so far, there is little knowledge about therapeutic effects of training when started in advanced disease stages. In the present study we show that following seven months of sedentary life style five months of wheel running, started four months after disease onset was still able to mitigate at least some aspects of the full-blown Alzheimer's pathology in TgCRND8 mice. Late running had mild but significant effects on structural plasticity by increasing the dendritic complexity. It further reduced beta-amyloid (Aβ) plaque burden and enhanced Aβ clearance across the blood-brain barrier, along with attenuating microgliosis, inflammation, oxidative stress, and autophagy deficits, resulting in better memory performance and less agitation. However, unlike early exercise, late running did not affect abnormal amyloid precursor protein metabolism, tau pathology, or angiogenesis. These results allow concluding that it is never too late to counteract Alzheimer's disease with physical training but the earlier the intervention starts, the more pronounced is the therapeutic potential.http://www.sciencedirect.com/science/article/pii/S096999611630136XLate physical activityAlzheimer's diseaseNeuroplasticityAβ metabolismInflammation & autophagy |
| spellingShingle | Arne Herring Yvonne Münster Judith Metzdorf Bastien Bolczek Sarah Krüssel David Krieter Ilkay Yavuz Fro Karim Constanze Roggendorf Anthony Stang Yachao Wang Dirk M. Hermann Sarah Teuber-Hanselmann Kathy Keyvani Late running is not too late against Alzheimer's pathology Neurobiology of Disease Late physical activity Alzheimer's disease Neuroplasticity Aβ metabolism Inflammation & autophagy |
| title | Late running is not too late against Alzheimer's pathology |
| title_full | Late running is not too late against Alzheimer's pathology |
| title_fullStr | Late running is not too late against Alzheimer's pathology |
| title_full_unstemmed | Late running is not too late against Alzheimer's pathology |
| title_short | Late running is not too late against Alzheimer's pathology |
| title_sort | late running is not too late against alzheimer s pathology |
| topic | Late physical activity Alzheimer's disease Neuroplasticity Aβ metabolism Inflammation & autophagy |
| url | http://www.sciencedirect.com/science/article/pii/S096999611630136X |
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