Effect of Fluvoxamine on Electrophysiological and Behavioral Alterations of Rats With Depression
Background: Depression is a serious mental illness with symptoms such as worry, disturbed sleep and appetite, lack of interest or pleasure, and persistent sorrow. Objectives: This study aims to assess the effect of fluvoxamine (FLX) on behavioral and electrophysiological alterations of the posterio...
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| Format: | Article |
| Language: | English |
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Guilan University of Medical Sciences
2024-04-01
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| Series: | Caspian Journal of Neurological Sciences |
| Subjects: | |
| Online Access: | http://cjns.gums.ac.ir/article-1-684-en.pdf |
| _version_ | 1797260167006388224 |
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| author | Mahsa Rahimi Iran Goudarzi Kambiz Rohampour |
| author_facet | Mahsa Rahimi Iran Goudarzi Kambiz Rohampour |
| author_sort | Mahsa Rahimi |
| collection | DOAJ |
| description | Background: Depression is a serious mental illness with symptoms such as worry, disturbed sleep and appetite, lack of interest or pleasure, and persistent sorrow.
Objectives: This study aims to assess the effect of fluvoxamine (FLX) on behavioral and electrophysiological alterations of the posterior cingulate cortex (PCC) and the hippocampus in rats with depression.
Materials & Methods: Thirty-two albino rats (weighing 250–300 g) were divided into four groups; control (sham), chronic mild stress (CMS), FLX, and CMS+FLX. The CMS was induced by applying different stressors for 3 weeks. Intraperitoneal injection of FLX (25 mg/Kg) was performed daily for 14 days in the treatment group. Depressive-like behaviors were assessed, and local field potentials (LFP) from the hippocampus and the PCC were recorded.
Results: FLX effectively reduced depressive-like behaviors in rats with CMS (P≤0.05). Additionally, depression-induced alterations in LFP were observed in the hippocampus and the PCC. Depression reduced the power of delta and theta bands and increased the hippocampal low-gamma band power (P≤0.05). In the PCC, depression increased the power of delta and low-gamma bands and reduced the power of the alpha band (P≤0.05).
Conclusion: FLX reduce depression-like behaviors in the animal model, possibly through affecting electrophysiological activity of the hippocampus and the PCC. |
| first_indexed | 2024-04-24T23:21:01Z |
| format | Article |
| id | doaj.art-d51b4d0e910e4372bb8782325a391e60 |
| institution | Directory Open Access Journal |
| issn | 2423-4818 |
| language | English |
| last_indexed | 2024-04-24T23:21:01Z |
| publishDate | 2024-04-01 |
| publisher | Guilan University of Medical Sciences |
| record_format | Article |
| series | Caspian Journal of Neurological Sciences |
| spelling | doaj.art-d51b4d0e910e4372bb8782325a391e602024-03-16T12:39:48ZengGuilan University of Medical SciencesCaspian Journal of Neurological Sciences2423-48182024-04-01102102110Effect of Fluvoxamine on Electrophysiological and Behavioral Alterations of Rats With DepressionMahsa Rahimi0Iran Goudarzi1Kambiz Rohampour2 School of Biology, Damghan University, Damghan, Iran. School of Biology, Damghan University, Damghan, Iran. Department of Physiology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. Background: Depression is a serious mental illness with symptoms such as worry, disturbed sleep and appetite, lack of interest or pleasure, and persistent sorrow. Objectives: This study aims to assess the effect of fluvoxamine (FLX) on behavioral and electrophysiological alterations of the posterior cingulate cortex (PCC) and the hippocampus in rats with depression. Materials & Methods: Thirty-two albino rats (weighing 250–300 g) were divided into four groups; control (sham), chronic mild stress (CMS), FLX, and CMS+FLX. The CMS was induced by applying different stressors for 3 weeks. Intraperitoneal injection of FLX (25 mg/Kg) was performed daily for 14 days in the treatment group. Depressive-like behaviors were assessed, and local field potentials (LFP) from the hippocampus and the PCC were recorded. Results: FLX effectively reduced depressive-like behaviors in rats with CMS (P≤0.05). Additionally, depression-induced alterations in LFP were observed in the hippocampus and the PCC. Depression reduced the power of delta and theta bands and increased the hippocampal low-gamma band power (P≤0.05). In the PCC, depression increased the power of delta and low-gamma bands and reduced the power of the alpha band (P≤0.05). Conclusion: FLX reduce depression-like behaviors in the animal model, possibly through affecting electrophysiological activity of the hippocampus and the PCC.http://cjns.gums.ac.ir/article-1-684-en.pdfdepressionhippocampusposterior cingulate cortexfluvoxaminelocal field potential recording |
| spellingShingle | Mahsa Rahimi Iran Goudarzi Kambiz Rohampour Effect of Fluvoxamine on Electrophysiological and Behavioral Alterations of Rats With Depression Caspian Journal of Neurological Sciences depression hippocampus posterior cingulate cortex fluvoxamine local field potential recording |
| title | Effect of Fluvoxamine on Electrophysiological and Behavioral Alterations of Rats With Depression |
| title_full | Effect of Fluvoxamine on Electrophysiological and Behavioral Alterations of Rats With Depression |
| title_fullStr | Effect of Fluvoxamine on Electrophysiological and Behavioral Alterations of Rats With Depression |
| title_full_unstemmed | Effect of Fluvoxamine on Electrophysiological and Behavioral Alterations of Rats With Depression |
| title_short | Effect of Fluvoxamine on Electrophysiological and Behavioral Alterations of Rats With Depression |
| title_sort | effect of fluvoxamine on electrophysiological and behavioral alterations of rats with depression |
| topic | depression hippocampus posterior cingulate cortex fluvoxamine local field potential recording |
| url | http://cjns.gums.ac.ir/article-1-684-en.pdf |
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