Membrane-wrapped nanoparticles for photothermal cancer therapy
Abstract Cancer is a global health problem that needs effective treatment strategies. Conventional treatments for solid-tumor cancers are unsatisfactory because they cause unintended harm to healthy tissues and are susceptible to cancer cell resistance. Nanoparticle-mediated photothermal therapy is...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2022-08-01
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| Series: | Nano Convergence |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40580-022-00328-4 |
| _version_ | 1798042692103438336 |
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| author | Sara B. Aboeleneen Mackenzie A. Scully Jenna C. Harris Eric H. Sterin Emily S. Day |
| author_facet | Sara B. Aboeleneen Mackenzie A. Scully Jenna C. Harris Eric H. Sterin Emily S. Day |
| author_sort | Sara B. Aboeleneen |
| collection | DOAJ |
| description | Abstract Cancer is a global health problem that needs effective treatment strategies. Conventional treatments for solid-tumor cancers are unsatisfactory because they cause unintended harm to healthy tissues and are susceptible to cancer cell resistance. Nanoparticle-mediated photothermal therapy is a minimally invasive treatment for solid-tumor cancers that has immense promise as a standalone therapy or adjuvant to other treatments like chemotherapy, immunotherapy, or radiotherapy. To maximize the success of photothermal therapy, light-responsive nanoparticles can be camouflaged with cell membranes to endow them with unique biointerfacing capabilities that reduce opsonization, prolong systemic circulation, and improve tumor delivery through enhanced passive accumulation or homotypic targeting. This ensures a sufficient dose of photoresponsive nanoparticles arrives at tumor sites to enable their complete thermal ablation. This review summarizes the state-of-the-art in cell membrane camouflaged nanoparticles for photothermal cancer therapy and provides insights to the path forward for clinical translation. |
| first_indexed | 2024-04-11T22:39:00Z |
| format | Article |
| id | doaj.art-d51b699834c14d1e8274f210aff48cd0 |
| institution | Directory Open Access Journal |
| issn | 2196-5404 |
| language | English |
| last_indexed | 2024-04-11T22:39:00Z |
| publishDate | 2022-08-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Nano Convergence |
| spelling | doaj.art-d51b699834c14d1e8274f210aff48cd02022-12-22T03:59:07ZengSpringerOpenNano Convergence2196-54042022-08-019112710.1186/s40580-022-00328-4Membrane-wrapped nanoparticles for photothermal cancer therapySara B. Aboeleneen0Mackenzie A. Scully1Jenna C. Harris2Eric H. Sterin3Emily S. Day4Biomedical Engineering, University of DelawareBiomedical Engineering, University of DelawareMaterials Science and Engineering, University of DelawareBiomedical Engineering, University of DelawareBiomedical Engineering, University of DelawareAbstract Cancer is a global health problem that needs effective treatment strategies. Conventional treatments for solid-tumor cancers are unsatisfactory because they cause unintended harm to healthy tissues and are susceptible to cancer cell resistance. Nanoparticle-mediated photothermal therapy is a minimally invasive treatment for solid-tumor cancers that has immense promise as a standalone therapy or adjuvant to other treatments like chemotherapy, immunotherapy, or radiotherapy. To maximize the success of photothermal therapy, light-responsive nanoparticles can be camouflaged with cell membranes to endow them with unique biointerfacing capabilities that reduce opsonization, prolong systemic circulation, and improve tumor delivery through enhanced passive accumulation or homotypic targeting. This ensures a sufficient dose of photoresponsive nanoparticles arrives at tumor sites to enable their complete thermal ablation. This review summarizes the state-of-the-art in cell membrane camouflaged nanoparticles for photothermal cancer therapy and provides insights to the path forward for clinical translation.https://doi.org/10.1186/s40580-022-00328-4PhototherapyMultimodal therapyTargetingBiomimicryBiomimeticNanomedicine |
| spellingShingle | Sara B. Aboeleneen Mackenzie A. Scully Jenna C. Harris Eric H. Sterin Emily S. Day Membrane-wrapped nanoparticles for photothermal cancer therapy Nano Convergence Phototherapy Multimodal therapy Targeting Biomimicry Biomimetic Nanomedicine |
| title | Membrane-wrapped nanoparticles for photothermal cancer therapy |
| title_full | Membrane-wrapped nanoparticles for photothermal cancer therapy |
| title_fullStr | Membrane-wrapped nanoparticles for photothermal cancer therapy |
| title_full_unstemmed | Membrane-wrapped nanoparticles for photothermal cancer therapy |
| title_short | Membrane-wrapped nanoparticles for photothermal cancer therapy |
| title_sort | membrane wrapped nanoparticles for photothermal cancer therapy |
| topic | Phototherapy Multimodal therapy Targeting Biomimicry Biomimetic Nanomedicine |
| url | https://doi.org/10.1186/s40580-022-00328-4 |
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