Renal fibrosis
Renal fibrosis, characterized by tubulointerstitial fibrosis and glomerulosclerosis, is the final manifestation of chronic kidney disease. Renal fibrosis is characterized by an excessive accumulation and deposition of extracellular matrix components. This pathologic result usually originates from bo...
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| Format: | Article |
| Language: | English |
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Korean Pediatric Society
2010-07-01
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| Series: | Korean Journal of Pediatrics |
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| Online Access: | http://kjp.or.kr/upload/pdf/kjped-53-735.pdf |
| _version_ | 1819232141518569472 |
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| author | Min Hyun Cho |
| author_facet | Min Hyun Cho |
| author_sort | Min Hyun Cho |
| collection | DOAJ |
| description | Renal fibrosis, characterized by tubulointerstitial fibrosis and glomerulosclerosis, is the final manifestation of chronic kidney disease. Renal fibrosis is characterized by an excessive accumulation and deposition of extracellular matrix components. This pathologic result usually originates from both underlying complicated cellular activities such as epithelial-to-mesenchymal transition, fibroblast activation, monocyte/macrophage infiltration, and cellular apoptosis and the activation of signaling molecules such as transforming growth factor beta and angiotensin II. However, because the pathogenesis of renal fibrosis is extremely complicated and our knowledge regarding this condition is still limited, further studies are needed. |
| first_indexed | 2024-12-23T11:56:08Z |
| format | Article |
| id | doaj.art-d51b69b3c85d434e8855d0391b70845b |
| institution | Directory Open Access Journal |
| issn | 1738-1061 2092-7258 |
| language | English |
| last_indexed | 2024-12-23T11:56:08Z |
| publishDate | 2010-07-01 |
| publisher | Korean Pediatric Society |
| record_format | Article |
| series | Korean Journal of Pediatrics |
| spelling | doaj.art-d51b69b3c85d434e8855d0391b70845b2022-12-21T17:48:05ZengKorean Pediatric SocietyKorean Journal of Pediatrics1738-10612092-72582010-07-0153773574010.3345/kjp.2010.53.7.7352010530702Renal fibrosisMin Hyun Cho0Department of Pediatrics, Kyungpook National University School of Medicine, Daegu, Korea.Renal fibrosis, characterized by tubulointerstitial fibrosis and glomerulosclerosis, is the final manifestation of chronic kidney disease. Renal fibrosis is characterized by an excessive accumulation and deposition of extracellular matrix components. This pathologic result usually originates from both underlying complicated cellular activities such as epithelial-to-mesenchymal transition, fibroblast activation, monocyte/macrophage infiltration, and cellular apoptosis and the activation of signaling molecules such as transforming growth factor beta and angiotensin II. However, because the pathogenesis of renal fibrosis is extremely complicated and our knowledge regarding this condition is still limited, further studies are needed.http://kjp.or.kr/upload/pdf/kjped-53-735.pdfFibrosisGlomerulosclerosisKidney disease |
| spellingShingle | Min Hyun Cho Renal fibrosis Korean Journal of Pediatrics Fibrosis Glomerulosclerosis Kidney disease |
| title | Renal fibrosis |
| title_full | Renal fibrosis |
| title_fullStr | Renal fibrosis |
| title_full_unstemmed | Renal fibrosis |
| title_short | Renal fibrosis |
| title_sort | renal fibrosis |
| topic | Fibrosis Glomerulosclerosis Kidney disease |
| url | http://kjp.or.kr/upload/pdf/kjped-53-735.pdf |
| work_keys_str_mv | AT minhyuncho renalfibrosis |