AngioJet Thrombectomy Versus Catheter-Directed Thrombolysis for Lower Extremity Deep Vein Thrombosis: A Meta-Analysis of Clinical Trials
Early catheter-directed thrombolysis (CDT) for lower extremity deep vein thrombosis (LEDVT) can reduce post-thrombotic morbidity and the AngioJet thrombectomy is a new therapy that can be selected for the treatment of LEDVT. We performed a systematic review and meta-analysis of clinical trials compa...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2021-04-01
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| Series: | Clinical and Applied Thrombosis/Hemostasis |
| Online Access: | https://doi.org/10.1177/10760296211005548 |
| _version_ | 1818596568788369408 |
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| author | Guan Qiang Li MD Lei Wang MD Xi Cheng Zhang MD |
| author_facet | Guan Qiang Li MD Lei Wang MD Xi Cheng Zhang MD |
| author_sort | Guan Qiang Li MD |
| collection | DOAJ |
| description | Early catheter-directed thrombolysis (CDT) for lower extremity deep vein thrombosis (LEDVT) can reduce post-thrombotic morbidity and the AngioJet thrombectomy is a new therapy that can be selected for the treatment of LEDVT. We performed a systematic review and meta-analysis of clinical trials comparing AngioJet versus CDT to assess the efficacy and safety of AngioJet thrombectomy. We systematically searched PubMed and Embase for clinical trials that published before November 1, 2020 and compared AngioJet thrombectomy and CDT in the treatment of LEDVT. We meta-analyzed effective rate of treatment, serious complications, PTS, Villalta score, duration of treatment and drug dose. AngioJet does not result in a significant difference in the effective rate (OR 1.00, CI 0.73-1.36, P = 0.98; I 2 = 0%) and complications (OR 1.16 CI 0.84-1.61, P = 0.36; I 2 = 39%) compare to CDT. And there was a statistically significant decrease in incidence of PTS (OR 0.58 CI 0.37-0.91, P = 0.02; I 2 = 0%) and Villalta score (OR −1.86 CI −3.49 to −0.24, P = 0.02; I 2 = 34%) for AngioJet compared to CDT. In addition, there was a statistically significant decrease in duration of the treatment (OR −2.45 CI −2.75 to −2.15, P < 0.0001; I 2 = 95%) and drug dose (OR −3.15 CI −3.38 to −2.93, P < 0.0001; I 2 = 98%) between AngioJet and CDT. AngioJet results in a low severity of PTS compared to CDT therapy. Moreover, the average duration of treatment and thrombolysis time was shorter in the AngioJet group compared to the CDT group. However, the AngioJet group was not significantly different in effective rate of treatment and serious complications compared to the CDT group. |
| first_indexed | 2024-12-16T11:33:59Z |
| format | Article |
| id | doaj.art-d51bc726fba84190a0f4089720c4bff0 |
| institution | Directory Open Access Journal |
| issn | 1938-2723 |
| language | English |
| last_indexed | 2024-12-16T11:33:59Z |
| publishDate | 2021-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Clinical and Applied Thrombosis/Hemostasis |
| spelling | doaj.art-d51bc726fba84190a0f4089720c4bff02022-12-21T22:33:09ZengSAGE PublishingClinical and Applied Thrombosis/Hemostasis1938-27232021-04-012710.1177/10760296211005548AngioJet Thrombectomy Versus Catheter-Directed Thrombolysis for Lower Extremity Deep Vein Thrombosis: A Meta-Analysis of Clinical TrialsGuan Qiang Li MD0Lei Wang MD1Xi Cheng Zhang MD2 Department of Vascular Surgery, , Yangzhou, China Department of Vascular Surgery, , Yangzhou, China Dushu Lake Hospital Affiliated to Soochow University, Soochow, ChinaEarly catheter-directed thrombolysis (CDT) for lower extremity deep vein thrombosis (LEDVT) can reduce post-thrombotic morbidity and the AngioJet thrombectomy is a new therapy that can be selected for the treatment of LEDVT. We performed a systematic review and meta-analysis of clinical trials comparing AngioJet versus CDT to assess the efficacy and safety of AngioJet thrombectomy. We systematically searched PubMed and Embase for clinical trials that published before November 1, 2020 and compared AngioJet thrombectomy and CDT in the treatment of LEDVT. We meta-analyzed effective rate of treatment, serious complications, PTS, Villalta score, duration of treatment and drug dose. AngioJet does not result in a significant difference in the effective rate (OR 1.00, CI 0.73-1.36, P = 0.98; I 2 = 0%) and complications (OR 1.16 CI 0.84-1.61, P = 0.36; I 2 = 39%) compare to CDT. And there was a statistically significant decrease in incidence of PTS (OR 0.58 CI 0.37-0.91, P = 0.02; I 2 = 0%) and Villalta score (OR −1.86 CI −3.49 to −0.24, P = 0.02; I 2 = 34%) for AngioJet compared to CDT. In addition, there was a statistically significant decrease in duration of the treatment (OR −2.45 CI −2.75 to −2.15, P < 0.0001; I 2 = 95%) and drug dose (OR −3.15 CI −3.38 to −2.93, P < 0.0001; I 2 = 98%) between AngioJet and CDT. AngioJet results in a low severity of PTS compared to CDT therapy. Moreover, the average duration of treatment and thrombolysis time was shorter in the AngioJet group compared to the CDT group. However, the AngioJet group was not significantly different in effective rate of treatment and serious complications compared to the CDT group.https://doi.org/10.1177/10760296211005548 |
| spellingShingle | Guan Qiang Li MD Lei Wang MD Xi Cheng Zhang MD AngioJet Thrombectomy Versus Catheter-Directed Thrombolysis for Lower Extremity Deep Vein Thrombosis: A Meta-Analysis of Clinical Trials Clinical and Applied Thrombosis/Hemostasis |
| title | AngioJet Thrombectomy Versus Catheter-Directed Thrombolysis for Lower Extremity Deep Vein Thrombosis: A Meta-Analysis of Clinical Trials |
| title_full | AngioJet Thrombectomy Versus Catheter-Directed Thrombolysis for Lower Extremity Deep Vein Thrombosis: A Meta-Analysis of Clinical Trials |
| title_fullStr | AngioJet Thrombectomy Versus Catheter-Directed Thrombolysis for Lower Extremity Deep Vein Thrombosis: A Meta-Analysis of Clinical Trials |
| title_full_unstemmed | AngioJet Thrombectomy Versus Catheter-Directed Thrombolysis for Lower Extremity Deep Vein Thrombosis: A Meta-Analysis of Clinical Trials |
| title_short | AngioJet Thrombectomy Versus Catheter-Directed Thrombolysis for Lower Extremity Deep Vein Thrombosis: A Meta-Analysis of Clinical Trials |
| title_sort | angiojet thrombectomy versus catheter directed thrombolysis for lower extremity deep vein thrombosis a meta analysis of clinical trials |
| url | https://doi.org/10.1177/10760296211005548 |
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