Comparisons of Radiofrequency Ablation, Microwave Ablation, and Irreversible Electroporation by Using Propensity Score Analysis for Early Stage Hepatocellular Carcinoma
Background: Despite the diversity of thermal ablations, such as radiofrequency ablation (RFA) and microwave ablation (MWA), and non-thermal ablation, such as irreversible electroporation (IRE) cross-comparisons of multiple ablative modalities for hepatocellular carcinoma (HCC) treatment remain scarc...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/3/732 |
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| author | Takuya Wada Katsutoshi Sugimoto Kentaro Sakamaki Hiroshi Takahashi Tatsuya Kakegawa Yusuke Tomita Masakazu Abe Yu Yoshimasu Hirohito Takeuchi Takao Itoi |
| author_facet | Takuya Wada Katsutoshi Sugimoto Kentaro Sakamaki Hiroshi Takahashi Tatsuya Kakegawa Yusuke Tomita Masakazu Abe Yu Yoshimasu Hirohito Takeuchi Takao Itoi |
| author_sort | Takuya Wada |
| collection | DOAJ |
| description | Background: Despite the diversity of thermal ablations, such as radiofrequency ablation (RFA) and microwave ablation (MWA), and non-thermal ablation, such as irreversible electroporation (IRE) cross-comparisons of multiple ablative modalities for hepatocellular carcinoma (HCC) treatment remain scarce. Thus, we investigated the therapeutic outcomes of different three ablation modalities in the treatment of early stage HCC. Methods: A total of 322 consecutive patients with 366 HCCs (mean tumor size ± standard deviation: 1.7 ± 0.9 cm) who underwent RFA (n = 216, 59.0%), MWA (n = 91, 28.3%), or IRE (n = 15, 4.7%) were included. Local tumor progression (LTP) rates for LTP were compared among the three modalities. Propensity score-matched analysis was used to reduce selection bias. Results: A significant difference in 2-year LTP rates between the IRE and RFA groups (IRE, 0.0% vs. RFA, 45.0%; <i>p</i> = 0.005) was found. There was no significant difference in 2-year LTP rates between the IRE and MWA groups (IRE, 0.0% vs. MWA, 25.0%; <i>p</i> = 0.103) as well as between the RFA and MWA groups (RFA, 18.2% vs. MWA, 20.6%; <i>p</i> = 0.586). Conclusion: IRE provides better local tumor control than RFA as a first-line therapeutic option for small perivascular HCC. |
| first_indexed | 2024-03-11T09:51:29Z |
| format | Article |
| id | doaj.art-d51d584202574b86a787b9b5f7501a90 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T09:51:29Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-d51d584202574b86a787b9b5f7501a902023-11-16T16:16:24ZengMDPI AGCancers2072-66942023-01-0115373210.3390/cancers15030732Comparisons of Radiofrequency Ablation, Microwave Ablation, and Irreversible Electroporation by Using Propensity Score Analysis for Early Stage Hepatocellular CarcinomaTakuya Wada0Katsutoshi Sugimoto1Kentaro Sakamaki2Hiroshi Takahashi3Tatsuya Kakegawa4Yusuke Tomita5Masakazu Abe6Yu Yoshimasu7Hirohito Takeuchi8Takao Itoi9Department of Gastroenterology and Hepatology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, JapanDepartment of Gastroenterology and Hepatology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, JapanCenter for Data Science, Yokohama City University, 22-2 Seto, Kanazawa-ku, Yokohama-shi 236-0027, Kanagawa, JapanDepartment of Gastroenterology and Hepatology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, JapanDepartment of Gastroenterology and Hepatology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, JapanDepartment of Gastroenterology and Hepatology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, JapanDepartment of Gastroenterology and Hepatology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, JapanDepartment of Gastroenterology and Hepatology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, JapanDepartment of Gastroenterology and Hepatology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, JapanDepartment of Gastroenterology and Hepatology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, JapanBackground: Despite the diversity of thermal ablations, such as radiofrequency ablation (RFA) and microwave ablation (MWA), and non-thermal ablation, such as irreversible electroporation (IRE) cross-comparisons of multiple ablative modalities for hepatocellular carcinoma (HCC) treatment remain scarce. Thus, we investigated the therapeutic outcomes of different three ablation modalities in the treatment of early stage HCC. Methods: A total of 322 consecutive patients with 366 HCCs (mean tumor size ± standard deviation: 1.7 ± 0.9 cm) who underwent RFA (n = 216, 59.0%), MWA (n = 91, 28.3%), or IRE (n = 15, 4.7%) were included. Local tumor progression (LTP) rates for LTP were compared among the three modalities. Propensity score-matched analysis was used to reduce selection bias. Results: A significant difference in 2-year LTP rates between the IRE and RFA groups (IRE, 0.0% vs. RFA, 45.0%; <i>p</i> = 0.005) was found. There was no significant difference in 2-year LTP rates between the IRE and MWA groups (IRE, 0.0% vs. MWA, 25.0%; <i>p</i> = 0.103) as well as between the RFA and MWA groups (RFA, 18.2% vs. MWA, 20.6%; <i>p</i> = 0.586). Conclusion: IRE provides better local tumor control than RFA as a first-line therapeutic option for small perivascular HCC.https://www.mdpi.com/2072-6694/15/3/732hepatocellular carcinomaradiofrequency ablationmicrowave ablationirreversible electroporation |
| spellingShingle | Takuya Wada Katsutoshi Sugimoto Kentaro Sakamaki Hiroshi Takahashi Tatsuya Kakegawa Yusuke Tomita Masakazu Abe Yu Yoshimasu Hirohito Takeuchi Takao Itoi Comparisons of Radiofrequency Ablation, Microwave Ablation, and Irreversible Electroporation by Using Propensity Score Analysis for Early Stage Hepatocellular Carcinoma Cancers hepatocellular carcinoma radiofrequency ablation microwave ablation irreversible electroporation |
| title | Comparisons of Radiofrequency Ablation, Microwave Ablation, and Irreversible Electroporation by Using Propensity Score Analysis for Early Stage Hepatocellular Carcinoma |
| title_full | Comparisons of Radiofrequency Ablation, Microwave Ablation, and Irreversible Electroporation by Using Propensity Score Analysis for Early Stage Hepatocellular Carcinoma |
| title_fullStr | Comparisons of Radiofrequency Ablation, Microwave Ablation, and Irreversible Electroporation by Using Propensity Score Analysis for Early Stage Hepatocellular Carcinoma |
| title_full_unstemmed | Comparisons of Radiofrequency Ablation, Microwave Ablation, and Irreversible Electroporation by Using Propensity Score Analysis for Early Stage Hepatocellular Carcinoma |
| title_short | Comparisons of Radiofrequency Ablation, Microwave Ablation, and Irreversible Electroporation by Using Propensity Score Analysis for Early Stage Hepatocellular Carcinoma |
| title_sort | comparisons of radiofrequency ablation microwave ablation and irreversible electroporation by using propensity score analysis for early stage hepatocellular carcinoma |
| topic | hepatocellular carcinoma radiofrequency ablation microwave ablation irreversible electroporation |
| url | https://www.mdpi.com/2072-6694/15/3/732 |
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