Body Mass Index and Vascular Disease in Men Aged 65 Years and Over: HIMS (Health In Men Study)
BackgroundUnderstanding the relationship between body mass index (BMI) and vascular disease at older age has become increasingly important in the many countries where both average age and BMI are rising. Methods and ResultsIn this prospective cohort study, 12 203 men (aged ≥65) were recruited in 199...
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| Format: | Article |
| Language: | English |
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Wiley
2017-12-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.117.007343 |
| _version_ | 1811275032358289408 |
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| author | Ben Lacey Bu B Yeap Jonathan Golledge Sarah Lewington Kieran A McCaul Paul E Norman Leon Flicker Osvaldo P Almeida Graeme J Hankey |
| author_facet | Ben Lacey Bu B Yeap Jonathan Golledge Sarah Lewington Kieran A McCaul Paul E Norman Leon Flicker Osvaldo P Almeida Graeme J Hankey |
| author_sort | Ben Lacey |
| collection | DOAJ |
| description | BackgroundUnderstanding the relationship between body mass index (BMI) and vascular disease at older age has become increasingly important in the many countries where both average age and BMI are rising. Methods and ResultsIn this prospective cohort study, 12 203 men (aged ≥65) were recruited in 1996–1999 from the general population in Perth, Australia. To limit reverse causality, analyses excluded those with past vascular disease and the first 4 years of follow‐up. During a further 8 (SD3) years of follow‐up, there were 1136 first‐ever major vascular events (nonfatal myocardial infarction, nonfatal stroke, or death from any vascular cause). Cox regression (adjusted for age, education, and smoking) related BMI at recruitment to incidence of major vascular events. At ages 65 to 94, the lowest risk of major vascular events was at ≈ 22.5 to 25 kg/m2. In the higher BMI range (≥25 kg/m2), 5 kg/m2 higher BMI was associated with 33% higher risk of major vascular events (hazard ratio, 1.33 [95% confidence interval, 1.18–1.49]): 24% higher risk of ischemic heart disease (1.24 [1.06–1.46]); 34% higher risk of stroke (1.34 [1.11–1.63]); and 78% higher risk of other vascular death (1.78 [1.32–2.41]). In the lower BMI range, there were fewer events and no strong evidence of an association (hazard ratio per 5 kg/m2 higher BMI, 0.82 [95% confidence interval, 0.61–1.12]). ConclusionsIn this population of older men, risk of major vascular events was lowest at ≈ 22.5 to 25 kg/m2. Above this range, BMI was strongly related to incidence of major vascular events, with each 5 kg/m2 higher BMI associated with ≈30% higher risk. |
| first_indexed | 2024-04-12T23:30:49Z |
| format | Article |
| id | doaj.art-d51e19cba89045788e9082e2d7749e07 |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-04-12T23:30:49Z |
| publishDate | 2017-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-d51e19cba89045788e9082e2d7749e072022-12-22T03:12:18ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802017-12-0161210.1161/JAHA.117.007343Body Mass Index and Vascular Disease in Men Aged 65 Years and Over: HIMS (Health In Men Study)Ben Lacey0Bu B Yeap1Jonathan Golledge2Sarah Lewington3Kieran A McCaul4Paul E Norman5Leon Flicker6Osvaldo P Almeida7Graeme J Hankey8Western Australian Centre for Health & Ageing, Centre for Medical Research, University of Western Australia, Perth, AustraliaSchool of Medicine and Pharmacology, University of Western Australia, Perth, AustraliaQueensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Townsville, AustraliaMRC Population Health Research Unit, Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, United KingdomWestern Australian Centre for Health & Ageing, Centre for Medical Research, University of Western Australia, Perth, AustraliaSchool of Surgery, University of Western Australia, Perth, AustraliaWestern Australian Centre for Health & Ageing, Centre for Medical Research, University of Western Australia, Perth, AustraliaWestern Australian Centre for Health & Ageing, Centre for Medical Research, University of Western Australia, Perth, AustraliaSchool of Medicine and Pharmacology, University of Western Australia, Perth, AustraliaBackgroundUnderstanding the relationship between body mass index (BMI) and vascular disease at older age has become increasingly important in the many countries where both average age and BMI are rising. Methods and ResultsIn this prospective cohort study, 12 203 men (aged ≥65) were recruited in 1996–1999 from the general population in Perth, Australia. To limit reverse causality, analyses excluded those with past vascular disease and the first 4 years of follow‐up. During a further 8 (SD3) years of follow‐up, there were 1136 first‐ever major vascular events (nonfatal myocardial infarction, nonfatal stroke, or death from any vascular cause). Cox regression (adjusted for age, education, and smoking) related BMI at recruitment to incidence of major vascular events. At ages 65 to 94, the lowest risk of major vascular events was at ≈ 22.5 to 25 kg/m2. In the higher BMI range (≥25 kg/m2), 5 kg/m2 higher BMI was associated with 33% higher risk of major vascular events (hazard ratio, 1.33 [95% confidence interval, 1.18–1.49]): 24% higher risk of ischemic heart disease (1.24 [1.06–1.46]); 34% higher risk of stroke (1.34 [1.11–1.63]); and 78% higher risk of other vascular death (1.78 [1.32–2.41]). In the lower BMI range, there were fewer events and no strong evidence of an association (hazard ratio per 5 kg/m2 higher BMI, 0.82 [95% confidence interval, 0.61–1.12]). ConclusionsIn this population of older men, risk of major vascular events was lowest at ≈ 22.5 to 25 kg/m2. Above this range, BMI was strongly related to incidence of major vascular events, with each 5 kg/m2 higher BMI associated with ≈30% higher risk.https://www.ahajournals.org/doi/10.1161/JAHA.117.007343adipositybody mass indexepidemiologyischemic heart diseasestrokevascular disease |
| spellingShingle | Ben Lacey Bu B Yeap Jonathan Golledge Sarah Lewington Kieran A McCaul Paul E Norman Leon Flicker Osvaldo P Almeida Graeme J Hankey Body Mass Index and Vascular Disease in Men Aged 65 Years and Over: HIMS (Health In Men Study) Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease adiposity body mass index epidemiology ischemic heart disease stroke vascular disease |
| title | Body Mass Index and Vascular Disease in Men Aged 65 Years and Over: HIMS (Health In Men Study) |
| title_full | Body Mass Index and Vascular Disease in Men Aged 65 Years and Over: HIMS (Health In Men Study) |
| title_fullStr | Body Mass Index and Vascular Disease in Men Aged 65 Years and Over: HIMS (Health In Men Study) |
| title_full_unstemmed | Body Mass Index and Vascular Disease in Men Aged 65 Years and Over: HIMS (Health In Men Study) |
| title_short | Body Mass Index and Vascular Disease in Men Aged 65 Years and Over: HIMS (Health In Men Study) |
| title_sort | body mass index and vascular disease in men aged 65 years and over hims health in men study |
| topic | adiposity body mass index epidemiology ischemic heart disease stroke vascular disease |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.117.007343 |
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