Late-Onset Retinal Degeneration: Clinical Perspectives
Leonardo Lando,1,2 Shyamanga Borooah1 1Shiley Eye Institute, University of California San Diego, La Jolla, CA, USA; 2Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, CanadaCorrespondence: Shyamanga Borooah, Shiley Eye Institute, University of California San Diego,...
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2022-09-01
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| Series: | Clinical Ophthalmology |
| Subjects: | |
| Online Access: | https://www.dovepress.com/late-onset-retinal-degeneration-clinical-perspectives-peer-reviewed-fulltext-article-OPTH |
| _version_ | 1828383448576819200 |
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| author | Lando L Borooah S |
| author_facet | Lando L Borooah S |
| author_sort | Lando L |
| collection | DOAJ |
| description | Leonardo Lando,1,2 Shyamanga Borooah1 1Shiley Eye Institute, University of California San Diego, La Jolla, CA, USA; 2Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, CanadaCorrespondence: Shyamanga Borooah, Shiley Eye Institute, University of California San Diego, 9415 Campus Point Drive, La Jolla, CA, 92093, USA, Email sborooah@health.ucsd.eduAbstract: Late-onset retinal degeneration (L-ORD) is a type of retinal dystrophy marked by nyctalopia and subretinal pigment epithelium deposits, which eventually promote retinal atrophy with final visual compromise. L-ORD may also present with changes in the anterior segment, notably long anterior zonules and iris atrophy, distinguishing it from other inherited eye conditions. Although it can clinically simulate age-related macular degeneration, L-ORD has a different course of progression and prognosis, requiring adequate diagnosis for patient counseling. This review summarizes the main clinical, genetic, pathophysiological, diagnostic, and therapeutic aspects of L-ORD to help ophthalmologists identify and manage this rare ocular disease.Keywords: retinal dystrophy, retinal degeneration, macular dystrophy, late-onset retinal degeneration, C1QTNF5, CTRP5 |
| first_indexed | 2024-12-10T04:48:11Z |
| format | Article |
| id | doaj.art-d5209b4ec6b24302b89a9302bad92dd3 |
| institution | Directory Open Access Journal |
| issn | 1177-5483 |
| language | English |
| last_indexed | 2024-12-10T04:48:11Z |
| publishDate | 2022-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Ophthalmology |
| spelling | doaj.art-d5209b4ec6b24302b89a9302bad92dd32022-12-22T02:01:41ZengDove Medical PressClinical Ophthalmology1177-54832022-09-01Volume 163225324678675Late-Onset Retinal Degeneration: Clinical PerspectivesLando LBorooah SLeonardo Lando,1,2 Shyamanga Borooah1 1Shiley Eye Institute, University of California San Diego, La Jolla, CA, USA; 2Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, CanadaCorrespondence: Shyamanga Borooah, Shiley Eye Institute, University of California San Diego, 9415 Campus Point Drive, La Jolla, CA, 92093, USA, Email sborooah@health.ucsd.eduAbstract: Late-onset retinal degeneration (L-ORD) is a type of retinal dystrophy marked by nyctalopia and subretinal pigment epithelium deposits, which eventually promote retinal atrophy with final visual compromise. L-ORD may also present with changes in the anterior segment, notably long anterior zonules and iris atrophy, distinguishing it from other inherited eye conditions. Although it can clinically simulate age-related macular degeneration, L-ORD has a different course of progression and prognosis, requiring adequate diagnosis for patient counseling. This review summarizes the main clinical, genetic, pathophysiological, diagnostic, and therapeutic aspects of L-ORD to help ophthalmologists identify and manage this rare ocular disease.Keywords: retinal dystrophy, retinal degeneration, macular dystrophy, late-onset retinal degeneration, C1QTNF5, CTRP5https://www.dovepress.com/late-onset-retinal-degeneration-clinical-perspectives-peer-reviewed-fulltext-article-OPTHretinal dystrophy retinal degeneration macular dystrophy late-onset retinal degeneration c1qtnf5 ctrp5 |
| spellingShingle | Lando L Borooah S Late-Onset Retinal Degeneration: Clinical Perspectives Clinical Ophthalmology retinal dystrophy retinal degeneration macular dystrophy late-onset retinal degeneration c1qtnf5 ctrp5 |
| title | Late-Onset Retinal Degeneration: Clinical Perspectives |
| title_full | Late-Onset Retinal Degeneration: Clinical Perspectives |
| title_fullStr | Late-Onset Retinal Degeneration: Clinical Perspectives |
| title_full_unstemmed | Late-Onset Retinal Degeneration: Clinical Perspectives |
| title_short | Late-Onset Retinal Degeneration: Clinical Perspectives |
| title_sort | late onset retinal degeneration clinical perspectives |
| topic | retinal dystrophy retinal degeneration macular dystrophy late-onset retinal degeneration c1qtnf5 ctrp5 |
| url | https://www.dovepress.com/late-onset-retinal-degeneration-clinical-perspectives-peer-reviewed-fulltext-article-OPTH |
| work_keys_str_mv | AT landol lateonsetretinaldegenerationclinicalperspectives AT borooahs lateonsetretinaldegenerationclinicalperspectives |