The PINK1 Activator Niclosamide Mitigates Mitochondrial Dysfunction and Thermal Hypersensitivity in a Paclitaxel-Induced <i>Drosophila</i> Model of Peripheral Neuropathy

The PINK1 Activator Niclosamide Mitigates Mitochondrial Dysfunction and Thermal Hypersensitivity in a Paclitaxel-Induced <i>Drosophila</i> Model of Peripheral Neuropathy

Paclitaxel is a widely used anticancer drug that induces dose-limiting peripheral neuropathy. Mitochondrial dysfunction has been implicated in paclitaxel-induced neuronal damage and in the onset of peripheral neuropathy. We have previously shown that the expression of PINK1, a key mediator of mitoch...

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Bibliographic Details
Main Authors: Hye-Ji Jang, Young-Yeon Kim, Kang-Min Lee, Jung-Eun Shin, Jeanho Yun
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Biomedicines
Subjects:
peripheral neuropathy
paclitaxel
niclosamide
PINK1
mitochondrial dysfunction
Online Access:https://www.mdpi.com/2227-9059/10/4/863

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