The Microbiome in Periodontitis and Diabetes
ObjectivesTo perform a comprehensive and integrative review of the available literature on the potential changes in the microbiome of healthy and individuals with diabetes under periodontal health and disease.Materials and MethodsThe review was conducted by two independent reviewers. Indexed electro...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Oral Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/froh.2022.859209/full |
| _version_ | 1819045441224835072 |
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| author | Davi Neto de Araújo Silva Maísa Casarin Sepehr Monajemzadeh Beatriz de Brito Bezerra Renate Lux Flavia Q. Pirih |
| author_facet | Davi Neto de Araújo Silva Maísa Casarin Sepehr Monajemzadeh Beatriz de Brito Bezerra Renate Lux Flavia Q. Pirih |
| author_sort | Davi Neto de Araújo Silva |
| collection | DOAJ |
| description | ObjectivesTo perform a comprehensive and integrative review of the available literature on the potential changes in the microbiome of healthy and individuals with diabetes under periodontal health and disease.Materials and MethodsThe review was conducted by two independent reviewers. Indexed electronic databases (PubMed/Medline, Cochrane Library, Web of Science and Scopus) were searched, including articles published in English and dated from 5 years ago until December 2021. A manual search also was performed to identify co-related articles. Following the removal of duplicates and eligibility criteria, the articles were included in tables for analysis and described in the manuscript.ResultsAccording to this review, diabetes mellitus was associated with significant changes in the subgingival and salivary microbiome, either in its association with periodontitis or in cases of periodontal health. In addition to affecting microbial diversity in terms of taxonomy, metagenomic studies have shown that this endocrine disorder may also be directly related to increased pathogenicity in the oral microbiome.ConclusionAlthough the reviewed studies demonstrate important differences in the subgingival and salivary microbiome composition because of diabetes mellitus, further studies are needed to clarify the real effects of hyperglycemia on oral microbial profiles and support new diagnostic approaches and innovative treatments. |
| first_indexed | 2024-12-21T10:28:37Z |
| format | Article |
| id | doaj.art-d5271e63917e4524bdc1eb2564ce01b5 |
| institution | Directory Open Access Journal |
| issn | 2673-4842 |
| language | English |
| last_indexed | 2024-12-21T10:28:37Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oral Health |
| spelling | doaj.art-d5271e63917e4524bdc1eb2564ce01b52022-12-21T19:07:16ZengFrontiers Media S.A.Frontiers in Oral Health2673-48422022-04-01310.3389/froh.2022.859209859209The Microbiome in Periodontitis and DiabetesDavi Neto de Araújo Silva0Maísa Casarin1Sepehr Monajemzadeh2Beatriz de Brito Bezerra3Renate Lux4Flavia Q. Pirih5Section of Periodontics, School of Dentistry, University of California, Los Angeles, Los Angeles, CA, United StatesSchool of Dentistry, Federal University of Pelotas, Pelotas, BrazilSection of Periodontics, School of Dentistry, University of California, Los Angeles, Los Angeles, CA, United StatesSection of Periodontics, School of Dentistry, University of California, Los Angeles, Los Angeles, CA, United StatesSection of Periodontics, School of Dentistry, University of California, Los Angeles, Los Angeles, CA, United StatesSection of Periodontics, School of Dentistry, University of California, Los Angeles, Los Angeles, CA, United StatesObjectivesTo perform a comprehensive and integrative review of the available literature on the potential changes in the microbiome of healthy and individuals with diabetes under periodontal health and disease.Materials and MethodsThe review was conducted by two independent reviewers. Indexed electronic databases (PubMed/Medline, Cochrane Library, Web of Science and Scopus) were searched, including articles published in English and dated from 5 years ago until December 2021. A manual search also was performed to identify co-related articles. Following the removal of duplicates and eligibility criteria, the articles were included in tables for analysis and described in the manuscript.ResultsAccording to this review, diabetes mellitus was associated with significant changes in the subgingival and salivary microbiome, either in its association with periodontitis or in cases of periodontal health. In addition to affecting microbial diversity in terms of taxonomy, metagenomic studies have shown that this endocrine disorder may also be directly related to increased pathogenicity in the oral microbiome.ConclusionAlthough the reviewed studies demonstrate important differences in the subgingival and salivary microbiome composition because of diabetes mellitus, further studies are needed to clarify the real effects of hyperglycemia on oral microbial profiles and support new diagnostic approaches and innovative treatments.https://www.frontiersin.org/articles/10.3389/froh.2022.859209/fullperiodontitisdiabetes mellitusoral microbiomegeneticsintegrative review |
| spellingShingle | Davi Neto de Araújo Silva Maísa Casarin Sepehr Monajemzadeh Beatriz de Brito Bezerra Renate Lux Flavia Q. Pirih The Microbiome in Periodontitis and Diabetes Frontiers in Oral Health periodontitis diabetes mellitus oral microbiome genetics integrative review |
| title | The Microbiome in Periodontitis and Diabetes |
| title_full | The Microbiome in Periodontitis and Diabetes |
| title_fullStr | The Microbiome in Periodontitis and Diabetes |
| title_full_unstemmed | The Microbiome in Periodontitis and Diabetes |
| title_short | The Microbiome in Periodontitis and Diabetes |
| title_sort | microbiome in periodontitis and diabetes |
| topic | periodontitis diabetes mellitus oral microbiome genetics integrative review |
| url | https://www.frontiersin.org/articles/10.3389/froh.2022.859209/full |
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