1H NMR Spectroscopy-Based Metabolomic Assessment of Uremic Toxicity, with Toxicological Outcomes, in Male Rats Following an Acute, Mid-Life Insult from Ochratoxin A

1H NMR Spectroscopy-Based Metabolomic Assessment of Uremic Toxicity, with Toxicological Outcomes, in Male Rats Following an Acute, Mid-Life Insult from Ochratoxin A

Overt response to a single 6.25 mg dose of ochratoxin A (OTA) by oral gavage to 15 months male rats was progressive loss of weight during the following four days. Lost weight was restored within one month and animals had a normal life-span without OTA-related terminal disease. Decline in plasma OTA...

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Bibliographic Details
Main Authors: John P. Shockcor, Peter G. Mantle, Andrew W. Nicholls
Format: Article
Language:English
Published: MDPI AG 2011-05-01
Series:Toxins
Subjects:
metabolomics
polyuria
ochratoxin A
pharmacokinetics
toxicology
nephropathy
Online Access:http://www.mdpi.com/2072-6651/3/6/504/

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