Spontaneous medication-related osteonecrosis of the jaws in a 23-year-Old

Medication-related osteonecrosis is a well-documented yet rare complication of antiresorptive treatment. The risk of MRONJ is well established in the adult population but has yet to be established in the pediatric population. Additionally, the risk to this population in adulthood following many year...

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Main Authors: Brenden J. Manley, Timothy W. Neal, Shyam Indrakanti, Thomas Schlieve
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Oral and Maxillofacial Surgery Cases
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2214541922000487
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author Brenden J. Manley
Timothy W. Neal
Shyam Indrakanti
Thomas Schlieve
author_facet Brenden J. Manley
Timothy W. Neal
Shyam Indrakanti
Thomas Schlieve
author_sort Brenden J. Manley
collection DOAJ
description Medication-related osteonecrosis is a well-documented yet rare complication of antiresorptive treatment. The risk of MRONJ is well established in the adult population but has yet to be established in the pediatric population. Additionally, the risk to this population in adulthood following many years of antiresorptive use is unknown. This case report describes a patient who received long-term antiresorptive medication as an adolescent and spontaneously developed MRONJ at age 23. To the authors’ knowledge, this is the youngest patient with MRONJ reported in the literature.
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spelling doaj.art-d527edcb0ac24242b1df359c229daebc2023-02-26T04:27:17ZengElsevierOral and Maxillofacial Surgery Cases2214-54192023-03-0191100289Spontaneous medication-related osteonecrosis of the jaws in a 23-year-OldBrenden J. Manley0Timothy W. Neal1Shyam Indrakanti2Thomas Schlieve3Department of Surgery, Division of Oral and Maxillofacial Surgery, UT Southwestern/Parkland Memorial Hospital, USACorresponding author. DDS, UTSW Medical Center, 5323 Harry Hines Boulevard, Dallas, TX, 75390, , USA.; Department of Surgery, Division of Oral and Maxillofacial Surgery, UT Southwestern/Parkland Memorial Hospital, USADepartment of Surgery, Division of Oral and Maxillofacial Surgery, UT Southwestern/Parkland Memorial Hospital, USADepartment of Surgery, Division of Oral and Maxillofacial Surgery, UT Southwestern/Parkland Memorial Hospital, USAMedication-related osteonecrosis is a well-documented yet rare complication of antiresorptive treatment. The risk of MRONJ is well established in the adult population but has yet to be established in the pediatric population. Additionally, the risk to this population in adulthood following many years of antiresorptive use is unknown. This case report describes a patient who received long-term antiresorptive medication as an adolescent and spontaneously developed MRONJ at age 23. To the authors’ knowledge, this is the youngest patient with MRONJ reported in the literature.http://www.sciencedirect.com/science/article/pii/S2214541922000487AntiresorptiveOsteonecrosisBisphosphonate
spellingShingle Brenden J. Manley
Timothy W. Neal
Shyam Indrakanti
Thomas Schlieve
Spontaneous medication-related osteonecrosis of the jaws in a 23-year-Old
Oral and Maxillofacial Surgery Cases
Antiresorptive
Osteonecrosis
Bisphosphonate
title Spontaneous medication-related osteonecrosis of the jaws in a 23-year-Old
title_full Spontaneous medication-related osteonecrosis of the jaws in a 23-year-Old
title_fullStr Spontaneous medication-related osteonecrosis of the jaws in a 23-year-Old
title_full_unstemmed Spontaneous medication-related osteonecrosis of the jaws in a 23-year-Old
title_short Spontaneous medication-related osteonecrosis of the jaws in a 23-year-Old
title_sort spontaneous medication related osteonecrosis of the jaws in a 23 year old
topic Antiresorptive
Osteonecrosis
Bisphosphonate
url http://www.sciencedirect.com/science/article/pii/S2214541922000487
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