Tussilagone Suppresses Angiogenesis by Inhibiting the VEGFR2 Signaling Pathway
Tussilagone (TSL) is a sesquiterpenoid isolated from Tussilago farfara, which has been used as a traditional medicine for the treatment of asthma and bronchitis. It also takes part in the anti-inflammatory and antioxidant effects, but its role in angiogenesis is unknown. Angiogenesis is a cancer fea...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-07-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphar.2019.00764/full |
| _version_ | 1828438261742174208 |
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| author | Jia Li Jia Li Jiangtong Peng Jiangtong Peng Shengnan Zhao Shengnan Zhao Yi Zhong Yi Zhong Yilong Wang Yilong Wang Ji Hu Ji Hu Chao Zhang Min Cheng Min Cheng Geqing Xia Yu Hu Kai Huang Kai Huang Yan Wang Yan Wang Minglu Liang |
| author_facet | Jia Li Jia Li Jiangtong Peng Jiangtong Peng Shengnan Zhao Shengnan Zhao Yi Zhong Yi Zhong Yilong Wang Yilong Wang Ji Hu Ji Hu Chao Zhang Min Cheng Min Cheng Geqing Xia Yu Hu Kai Huang Kai Huang Yan Wang Yan Wang Minglu Liang |
| author_sort | Jia Li |
| collection | DOAJ |
| description | Tussilagone (TSL) is a sesquiterpenoid isolated from Tussilago farfara, which has been used as a traditional medicine for the treatment of asthma and bronchitis. It also takes part in the anti-inflammatory and antioxidant effects, but its role in angiogenesis is unknown. Angiogenesis is a cancer feature that is essential for supplying oxygen and nutrients to all proliferating tumor cells. Here, we demonstrated that TSL significantly inhibited the proliferation, migration, invasion, and tube formation of primary human umbilical vascular endothelial cell (HUVEC) in vitro. Also, TSL inhibited vascular endothelial growth factor (VEGF)-induced angiogenesis revealed by Matrigel plug assay in vivo. At present, we observed that TSL inhibited the activity of VEGFR2 signal pathway induced by VEGF. These findings suggested that TSL may serve as a potential therapeutic target in the angiogenesis. |
| first_indexed | 2024-12-10T20:00:31Z |
| format | Article |
| id | doaj.art-d52a962a6c874dd39d0c939a539a7efa |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-10T20:00:31Z |
| publishDate | 2019-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-d52a962a6c874dd39d0c939a539a7efa2022-12-22T01:35:32ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122019-07-011010.3389/fphar.2019.00764446630Tussilagone Suppresses Angiogenesis by Inhibiting the VEGFR2 Signaling PathwayJia Li0Jia Li1Jiangtong Peng2Jiangtong Peng3Shengnan Zhao4Shengnan Zhao5Yi Zhong6Yi Zhong7Yilong Wang8Yilong Wang9Ji Hu10Ji Hu11Chao Zhang12Min Cheng13Min Cheng14Geqing Xia15Yu Hu16Kai Huang17Kai Huang18Yan Wang19Yan Wang20Minglu Liang21Clinic Center of Human Genomic Research, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaClinic Center of Human Genomic Research, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaClinic Center of Human Genomic Research, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Vascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaClinic Center of Human Genomic Research, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaClinic Center of Human Genomic Research, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaClinic Center of Human Genomic Research, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaInstitute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaClinic Center of Human Genomic Research, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaInstitute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaClinic Center of Human Genomic Research, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaClinic Center of Human Genomic Research, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaClinic Center of Human Genomic Research, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaTussilagone (TSL) is a sesquiterpenoid isolated from Tussilago farfara, which has been used as a traditional medicine for the treatment of asthma and bronchitis. It also takes part in the anti-inflammatory and antioxidant effects, but its role in angiogenesis is unknown. Angiogenesis is a cancer feature that is essential for supplying oxygen and nutrients to all proliferating tumor cells. Here, we demonstrated that TSL significantly inhibited the proliferation, migration, invasion, and tube formation of primary human umbilical vascular endothelial cell (HUVEC) in vitro. Also, TSL inhibited vascular endothelial growth factor (VEGF)-induced angiogenesis revealed by Matrigel plug assay in vivo. At present, we observed that TSL inhibited the activity of VEGFR2 signal pathway induced by VEGF. These findings suggested that TSL may serve as a potential therapeutic target in the angiogenesis.https://www.frontiersin.org/article/10.3389/fphar.2019.00764/fullangiogenesisTUSSILAGONEVEGFR2 signaling pathwayhuman umbilical vascular endothelial cellvascular endothelial growth factor |
| spellingShingle | Jia Li Jia Li Jiangtong Peng Jiangtong Peng Shengnan Zhao Shengnan Zhao Yi Zhong Yi Zhong Yilong Wang Yilong Wang Ji Hu Ji Hu Chao Zhang Min Cheng Min Cheng Geqing Xia Yu Hu Kai Huang Kai Huang Yan Wang Yan Wang Minglu Liang Tussilagone Suppresses Angiogenesis by Inhibiting the VEGFR2 Signaling Pathway Frontiers in Pharmacology angiogenesis TUSSILAGONE VEGFR2 signaling pathway human umbilical vascular endothelial cell vascular endothelial growth factor |
| title | Tussilagone Suppresses Angiogenesis by Inhibiting the VEGFR2 Signaling Pathway |
| title_full | Tussilagone Suppresses Angiogenesis by Inhibiting the VEGFR2 Signaling Pathway |
| title_fullStr | Tussilagone Suppresses Angiogenesis by Inhibiting the VEGFR2 Signaling Pathway |
| title_full_unstemmed | Tussilagone Suppresses Angiogenesis by Inhibiting the VEGFR2 Signaling Pathway |
| title_short | Tussilagone Suppresses Angiogenesis by Inhibiting the VEGFR2 Signaling Pathway |
| title_sort | tussilagone suppresses angiogenesis by inhibiting the vegfr2 signaling pathway |
| topic | angiogenesis TUSSILAGONE VEGFR2 signaling pathway human umbilical vascular endothelial cell vascular endothelial growth factor |
| url | https://www.frontiersin.org/article/10.3389/fphar.2019.00764/full |
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