Tussilagone Suppresses Angiogenesis by Inhibiting the VEGFR2 Signaling Pathway

Tussilagone Suppresses Angiogenesis by Inhibiting the VEGFR2 Signaling Pathway

Tussilagone (TSL) is a sesquiterpenoid isolated from Tussilago farfara, which has been used as a traditional medicine for the treatment of asthma and bronchitis. It also takes part in the anti-inflammatory and antioxidant effects, but its role in angiogenesis is unknown. Angiogenesis is a cancer fea...

Full description

Bibliographic Details
Main Authors:	Jia Li, Jiangtong Peng, Shengnan Zhao, Yi Zhong, Yilong Wang, Ji Hu, Chao Zhang, Min Cheng, Geqing Xia, Yu Hu, Kai Huang, Yan Wang, Minglu Liang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2019-07-01
Series:	Frontiers in Pharmacology
Subjects:	angiogenesis TUSSILAGONE VEGFR2 signaling pathway human umbilical vascular endothelial cell vascular endothelial growth factor
Online Access:	https://www.frontiersin.org/article/10.3389/fphar.2019.00764/full

Similar Items

Antiplatelet Activity of Tussilagone via Inhibition of the GPVI Downstream Signaling Pathway in Platelets
by: Jing Zhou, et al.
Published: (2020-07-01)

Tussilagone Reduces Tumorigenesis by Diminishing Inflammation in Experimental Colitis-Associated Colon Cancer
by: Sang-Hyeon Nam, et al.
Published: (2020-04-01)

Suramin Affects the Renal VEGF-A/VEGFR Axis in Short-Term Streptozotocin-Induced Diabetes
by: Gabriela Chyła-Danił, et al.
Published: (2023-03-01)

Coral-Derived Compound WA-25 Inhibits Angiogenesis by Attenuating the VEGF/VEGFR2 Signaling Pathway
by: Shih-Wei Lin, et al.
Published: (2015-02-01)

Live-imaging of endothelial Erk activity reveals dynamic and sequential signalling events during regenerative angiogenesis
by: Kazuhide S Okuda, et al.
Published: (2021-05-01)

The Effect of Combined Training and L-arginine Supplement on the Serum Levels of Adropin, VEGFR-2, and Nitric Oxide in Post-menopausal Hypertensive Women
by: Rozita Nourbakhsh, et al.
Published: (2022-04-01)

Association between the VEGFR-2 -604T/C polymorphism (rs2071559) and type 2 diabetic retinopathy
by: Yuan Yazhen, et al.
Published: (2023-03-01)

Antitumor Effect of 131I-Labeled Anti-VEGFR2 Targeted Mesoporous Silica Nanoparticles in Anaplastic Thyroid Cancer
by: Ruiguo Zhang, et al.
Published: (2019-03-01)

Dysregulation of Lymphatic Endothelial VEGFR3 Signaling in Disease
by: Kevin Kuonqui, et al.
Published: (2023-12-01)

Comprehensive analysis of VEGF/VEGFR inhibitor-induced immune-mediated hypertension: integrating pharmacovigilance, clinical data, and preclinical models
by: Hongyu Kuang, et al.
Published: (2024-10-01)

FAK Regulates VEGFR2 Expression and Promotes Angiogenesis in Triple-Negative Breast Cancer
by: Jun-Ping Shiau, et al.
Published: (2021-11-01)

Paeonol Promotes Reendothelialization After Vascular Injury Through Activation of c-Myc/VEGFR2 Signaling Pathway
by: Wang Y, et al.
Published: (2023-05-01)

Predicting Angiogenesis by Endothelial Progenitor Cells Relying on In-Vitro Function Assays and VEGFR-2 Expression Levels
by: Nadin Sabbah, et al.
Published: (2019-11-01)

Streptozotocin induced diabetic retinopathy in rat and the expression of vascular endothelial growth factor and its receptor
by: Chen-Yuan Gong, et al.
Published: (2013-10-01)

A Recombinant Lentiviral Vegfr2-Silencing Vector Attenuates Roxarsone-Promoted Growth of Rat Vascular Endothelial Cells and Angiogenesis in Matrigel Plug and B16F10 Xenograft Models
by: Xin Chen, et al.
Published: (2024-09-01)

Vascular permeability in retinopathy is regulated by VEGFR2 Y949 signaling to VE-cadherin
by: Ross O Smith, et al.
Published: (2020-04-01)

Serum Levels of VEGF-A and Its Receptors in Patients in Different Phases of Hemorrhagic and Ischemic Strokes
by: Anastasiya S. Babkina, et al.
Published: (2022-10-01)

VEGFR2 but not VEGFR3 governs integrity and remodeling of thyroid angiofollicular unit in normal state and during goitrogenesis
by: Jeon Yeob Jang, et al.
Published: (2017-04-01)

Anti-Angiogenetic and Anti-Lymphangiogenic Effects of a Novel 2-Aminobenzimidazole Derivative, MFB
by: Ming-Jen Hsu, et al.
Published: (2022-06-01)

The Association between Vascular Endothelial Growth Factor-related Factors with Severity of Multiple Sclerosis
by: Ebrahim Kouchaki, et al.
Published: (2016-06-01)

Effects of omentin on endothelial disruption and hydrogen peroxide-induced inflammation in vascular endothelial cell monolayer
by: Kamaruddin, Nur Aqilah
Published: (2022)

Vascular Endothelial Cells: Heterogeneity and Targeting Approaches
by: Jan K. Hennigs, et al.
Published: (2021-10-01)

Beta IV spectrin inhibits the metastatic growth of melanoma by suppressing VEGFR2‐driven tumor angiogenesis
by: Eun‐A. Kwak, et al.
Published: (2023-09-01)

The impact of periodontitis on vascular endothelial dysfunction
by: Qian Li, et al.
Published: (2022-09-01)

Suppressing VEGF-A/VEGFR-2 Signaling Contributes to the Anti-Angiogenic Effects of PPE8, a Novel Naphthoquinone-Based Compound
by: Ming-Jen Hsu, et al.
Published: (2022-07-01)

Endothelial microparticles: A mechanosensitive regulator of vascular homeostasis and injury under shear stress
by: Shuo Feng, et al.
Published: (2022-09-01)

Correlation of Serum Levels of IL-33, IL-37, Soluble Form of Vascular Endothelial Growth Factor Receptor 2 (VEGFR2), and Circulatory Frequency of VEGFR2-expressing Cells with Multiple Sclerosis Severity
by: Ebrahim Kouchaki, et al.
Published: (2017-08-01)

Mediating EGFR-TKI Resistance by VEGF/VEGFR Autocrine Pathway in Non-Small Cell Lung Cancer
by: Chike Osude, et al.
Published: (2022-05-01)

Case report: Kidney perivascular epithelioid cell tumor treated with anti-VEGFR tyrosine kinase inhibitor and MTOR inhibitor
by: Ninggang Zhang, et al.
Published: (2022-11-01)

Corrigendum: Dauricine attenuates vascular endothelial inflammation through inhibiting NF-κB pathway
by: Ji Hu, et al.
Published: (2023-08-01)

Dauricine Attenuates Vascular Endothelial Inflammation Through Inhibiting NF-κB Pathway
by: Ji Hu, et al.
Published: (2021-12-01)

Endothelial mesenchymal transformation and relationship with vascular abnormalities
by: Feng Chen, et al.
Published: (2022-09-01)

Insights into the Molecular Mechanism of Endothelial Glycocalyx Dysfunction during Heart Surgery
by: Antea Kršek, et al.
Published: (2024-04-01)

Polyethylene terephthalate electrospun nanofiber coated and blended with fibrin as scaffold for small diameter vascular graft /
by: Nur Syazana Rashidi, 1986-, author, et al.
Published: (2019)

Polyethylene terephthalate electrospun nanofiber coated and blended with fibrin as scaffold for small diameter vascular graft /
by: Nur Syazana Rashidi, 1986-, author, et al.
Published: (2019)

Antiangiogenic Effects of VH02, a Novel Urea Derivative: In Vitro and in Vivo Studies
by: Suwadee Phowichit, et al.
Published: (2016-09-01)

Selection of different endothelialization modes and different seed cells for tissue-engineered vascular graft
by: Qingjin Cai, et al.
Published: (2021-08-01)

The functional role of cellular senescence during vascular calcification in chronic kidney disease
by: Ya-Ping Fang, et al.
Published: (2024-01-01)

EXPRESSION OF THE VASCULAR ENDOTHELIAL GROWTH FACTOR AND ITS RECEPTORS (VEGFR-1 AND VEGFR-2) IN PRIMARY TUMOR CELLS IN PATIENTS WITH RENAL CANCER
by: D. A. Khochenkov, et al.
Published: (2021-08-01)

Tailored endothelialization enabled by engineered endothelial cell vesicles accelerates remodeling of small-diameter vascular grafts
by: Zihao Wang, et al.
Published: (2024-11-01)