Longitudinal NMR-Based Metabolomics Study Reveals How Hospitalized COVID-19 Patients Recover: Evidence of Dyslipidemia and Energy Metabolism Dysregulation
Long COVID, or post-acute sequelae of SARS-CoV-2 infection (PASC), can manifest as long-term symptoms in multiple organ systems, including respiratory, cardiovascular, neurological, and metabolic systems. In patients with severe COVID-19, immune dysregulation is significant, and the relationship bet...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/25/3/1523 |
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| author | Laura Ansone Vita Rovite Monta Brīvība Lauma Jagare Līva Pelcmane Daniella Borisova Anne Thews Roland Leiminger Jānis Kloviņš |
| author_facet | Laura Ansone Vita Rovite Monta Brīvība Lauma Jagare Līva Pelcmane Daniella Borisova Anne Thews Roland Leiminger Jānis Kloviņš |
| author_sort | Laura Ansone |
| collection | DOAJ |
| description | Long COVID, or post-acute sequelae of SARS-CoV-2 infection (PASC), can manifest as long-term symptoms in multiple organ systems, including respiratory, cardiovascular, neurological, and metabolic systems. In patients with severe COVID-19, immune dysregulation is significant, and the relationship between metabolic regulation and immune response is of great interest in determining the pathophysiological mechanisms. We aimed to characterize the metabolomic footprint of recovering severe COVID-19 patients at three consecutive timepoints and compare metabolite levels to controls. Our findings add proof of dysregulated amino acid metabolism in the acute phase and dyslipidemia, glycoprotein level alterations, and energy metabolism disturbances in severe COVID-19 patients 3–4 months post-hospitalization. |
| first_indexed | 2024-03-08T03:56:02Z |
| format | Article |
| id | doaj.art-d52aa4fb9dad4a608b229c070ddf2642 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-08T03:56:02Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-d52aa4fb9dad4a608b229c070ddf26422024-02-09T15:13:35ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672024-01-01253152310.3390/ijms25031523Longitudinal NMR-Based Metabolomics Study Reveals How Hospitalized COVID-19 Patients Recover: Evidence of Dyslipidemia and Energy Metabolism DysregulationLaura Ansone0Vita Rovite1Monta Brīvība2Lauma Jagare3Līva Pelcmane4Daniella Borisova5Anne Thews6Roland Leiminger7Jānis Kloviņš8Latvian Biomedical Research and Study Centre, LV-1067 Riga, LatviaLatvian Biomedical Research and Study Centre, LV-1067 Riga, LatviaLatvian Biomedical Research and Study Centre, LV-1067 Riga, LatviaLatvian Biomedical Research and Study Centre, LV-1067 Riga, LatviaLatvian Biomedical Research and Study Centre, LV-1067 Riga, LatviaLatvian Biomedical Research and Study Centre, LV-1067 Riga, LatviaBruker BioSpin GmbH & Co., Rudolf-Plank-Straße 23, 76275 Ettlingen, GermanyBruker BioSpin GmbH & Co., Rudolf-Plank-Straße 23, 76275 Ettlingen, GermanyLatvian Biomedical Research and Study Centre, LV-1067 Riga, LatviaLong COVID, or post-acute sequelae of SARS-CoV-2 infection (PASC), can manifest as long-term symptoms in multiple organ systems, including respiratory, cardiovascular, neurological, and metabolic systems. In patients with severe COVID-19, immune dysregulation is significant, and the relationship between metabolic regulation and immune response is of great interest in determining the pathophysiological mechanisms. We aimed to characterize the metabolomic footprint of recovering severe COVID-19 patients at three consecutive timepoints and compare metabolite levels to controls. Our findings add proof of dysregulated amino acid metabolism in the acute phase and dyslipidemia, glycoprotein level alterations, and energy metabolism disturbances in severe COVID-19 patients 3–4 months post-hospitalization.https://www.mdpi.com/1422-0067/25/3/1523COVID-19SARS-CoV-2post-acute sequelae of SARS-CoV-2 infectionpost-COVID-19 conditionpost-COVID-19 syndromemetabolomics |
| spellingShingle | Laura Ansone Vita Rovite Monta Brīvība Lauma Jagare Līva Pelcmane Daniella Borisova Anne Thews Roland Leiminger Jānis Kloviņš Longitudinal NMR-Based Metabolomics Study Reveals How Hospitalized COVID-19 Patients Recover: Evidence of Dyslipidemia and Energy Metabolism Dysregulation International Journal of Molecular Sciences COVID-19 SARS-CoV-2 post-acute sequelae of SARS-CoV-2 infection post-COVID-19 condition post-COVID-19 syndrome metabolomics |
| title | Longitudinal NMR-Based Metabolomics Study Reveals How Hospitalized COVID-19 Patients Recover: Evidence of Dyslipidemia and Energy Metabolism Dysregulation |
| title_full | Longitudinal NMR-Based Metabolomics Study Reveals How Hospitalized COVID-19 Patients Recover: Evidence of Dyslipidemia and Energy Metabolism Dysregulation |
| title_fullStr | Longitudinal NMR-Based Metabolomics Study Reveals How Hospitalized COVID-19 Patients Recover: Evidence of Dyslipidemia and Energy Metabolism Dysregulation |
| title_full_unstemmed | Longitudinal NMR-Based Metabolomics Study Reveals How Hospitalized COVID-19 Patients Recover: Evidence of Dyslipidemia and Energy Metabolism Dysregulation |
| title_short | Longitudinal NMR-Based Metabolomics Study Reveals How Hospitalized COVID-19 Patients Recover: Evidence of Dyslipidemia and Energy Metabolism Dysregulation |
| title_sort | longitudinal nmr based metabolomics study reveals how hospitalized covid 19 patients recover evidence of dyslipidemia and energy metabolism dysregulation |
| topic | COVID-19 SARS-CoV-2 post-acute sequelae of SARS-CoV-2 infection post-COVID-19 condition post-COVID-19 syndrome metabolomics |
| url | https://www.mdpi.com/1422-0067/25/3/1523 |
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