Exploring the longitudinal associations of functional network connectivity and psychiatric symptom changes in youth
Background: Functional connectivity has been associated with psychiatric problems, both in children and adults, but inconsistencies are present across studies. Prior research has mostly focused on small clinical samples with cross-sectional designs. Methods: We adopted a longitudinal design with rep...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | NeuroImage: Clinical |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158223000712 |
| _version_ | 1827925841269489664 |
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| author | Lorenza Dall'Aglio Fernando Estévez-López Mónica López-Vicente Bing Xu Oktay Agcaoglu Elias Boroda Kelvin O. Lim Vince D. Calhoun Henning Tiemeier Ryan L. Muetzel |
| author_facet | Lorenza Dall'Aglio Fernando Estévez-López Mónica López-Vicente Bing Xu Oktay Agcaoglu Elias Boroda Kelvin O. Lim Vince D. Calhoun Henning Tiemeier Ryan L. Muetzel |
| author_sort | Lorenza Dall'Aglio |
| collection | DOAJ |
| description | Background: Functional connectivity has been associated with psychiatric problems, both in children and adults, but inconsistencies are present across studies. Prior research has mostly focused on small clinical samples with cross-sectional designs. Methods: We adopted a longitudinal design with repeated assessments to investigate associations between functional network connectivity (FNC) and psychiatric problems in youth (9- to 17-year-olds, two time points) from the general population. The largest single-site study of pediatric neurodevelopment was used: Generation R (N = 3,131 with data at either time point). Psychiatric symptoms were measured with the Child Behavioral Checklist as broadband internalizing and externalizing problems, and its eight specific syndrome scales (e.g., anxious-depressed). FNC was assessed with two complementary approaches. First, static FNC (sFNC) was measured with graph theory-based metrics. Second, dynamic FNC (dFNC), where connectivity is allowed to vary over time, was summarized into 5 states that participants spent time in. Cross-lagged panel models were used to investigate the longitudinal bidirectional relationships of sFNC with internalizing and externalizing problems. Similar cross-lagged panel models were run for dFNC. Results: Small longitudinal relationships between dFNC and certain syndrome scales were observed, especially for baseline syndrome scales (i.e., rule-breaking, somatic complaints, thought problems, and attention problems) predicting connectivity changes. However, no association between any of the psychiatric problems (broadband and syndrome scales) with either measure of FNC survived correction for multiple testing. Conclusion: We found no or very modest evidence for longitudinal associations between psychiatric problems with dynamic and static FNC in this population-based sample. Differences in findings may stem from the population drawn, study design, developmental timing, and sample sizes. |
| first_indexed | 2024-03-13T05:28:50Z |
| format | Article |
| id | doaj.art-d52ae2a5378d40dc8bb1ca2ecec88b23 |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-03-13T05:28:50Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-d52ae2a5378d40dc8bb1ca2ecec88b232023-06-15T04:55:45ZengElsevierNeuroImage: Clinical2213-15822023-01-0138103382Exploring the longitudinal associations of functional network connectivity and psychiatric symptom changes in youthLorenza Dall'Aglio0Fernando Estévez-López1Mónica López-Vicente2Bing Xu3Oktay Agcaoglu4Elias Boroda5Kelvin O. Lim6Vince D. Calhoun7Henning Tiemeier8Ryan L. Muetzel9Department of Child and Adolescent Psychology and Psychiatry, Erasmus MC, Rotterdam, The Netherlands; The Generation R Study Group, Erasmus MC, Rotterdam, The NetherlandsDepartment of Social and Behavioral Sciences, Harvard T. Chan School of Public Health, Boston, USADepartment of Child and Adolescent Psychology and Psychiatry, Erasmus MC, Rotterdam, The Netherlands; The Generation R Study Group, Erasmus MC, Rotterdam, The NetherlandsDepartment of Child and Adolescent Psychology and Psychiatry, Erasmus MC, Rotterdam, The Netherlands; The Generation R Study Group, Erasmus MC, Rotterdam, The NetherlandsTri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University, Atlanta, USADepartment of Psychiatry and Behavioral Science, University of Minnesota, Minneapolis, USADepartment of Psychiatry and Behavioral Science, University of Minnesota, Minneapolis, USATri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University, Atlanta, USADepartment of Social and Behavioral Sciences, Harvard T. Chan School of Public Health, Boston, USA; Department of Child and Adolescent Psychology and Psychiatry, Erasmus MC, Rotterdam, The Netherlands; Corresponding author at: 677 Huntington Avenue, Boston, MA 02115, USA.Department of Child and Adolescent Psychology and Psychiatry, Erasmus MC, Rotterdam, The NetherlandsBackground: Functional connectivity has been associated with psychiatric problems, both in children and adults, but inconsistencies are present across studies. Prior research has mostly focused on small clinical samples with cross-sectional designs. Methods: We adopted a longitudinal design with repeated assessments to investigate associations between functional network connectivity (FNC) and psychiatric problems in youth (9- to 17-year-olds, two time points) from the general population. The largest single-site study of pediatric neurodevelopment was used: Generation R (N = 3,131 with data at either time point). Psychiatric symptoms were measured with the Child Behavioral Checklist as broadband internalizing and externalizing problems, and its eight specific syndrome scales (e.g., anxious-depressed). FNC was assessed with two complementary approaches. First, static FNC (sFNC) was measured with graph theory-based metrics. Second, dynamic FNC (dFNC), where connectivity is allowed to vary over time, was summarized into 5 states that participants spent time in. Cross-lagged panel models were used to investigate the longitudinal bidirectional relationships of sFNC with internalizing and externalizing problems. Similar cross-lagged panel models were run for dFNC. Results: Small longitudinal relationships between dFNC and certain syndrome scales were observed, especially for baseline syndrome scales (i.e., rule-breaking, somatic complaints, thought problems, and attention problems) predicting connectivity changes. However, no association between any of the psychiatric problems (broadband and syndrome scales) with either measure of FNC survived correction for multiple testing. Conclusion: We found no or very modest evidence for longitudinal associations between psychiatric problems with dynamic and static FNC in this population-based sample. Differences in findings may stem from the population drawn, study design, developmental timing, and sample sizes.http://www.sciencedirect.com/science/article/pii/S2213158223000712Functional MRIPsychopathologyAdolescenceLongitudinal studiesBrain development |
| spellingShingle | Lorenza Dall'Aglio Fernando Estévez-López Mónica López-Vicente Bing Xu Oktay Agcaoglu Elias Boroda Kelvin O. Lim Vince D. Calhoun Henning Tiemeier Ryan L. Muetzel Exploring the longitudinal associations of functional network connectivity and psychiatric symptom changes in youth NeuroImage: Clinical Functional MRI Psychopathology Adolescence Longitudinal studies Brain development |
| title | Exploring the longitudinal associations of functional network connectivity and psychiatric symptom changes in youth |
| title_full | Exploring the longitudinal associations of functional network connectivity and psychiatric symptom changes in youth |
| title_fullStr | Exploring the longitudinal associations of functional network connectivity and psychiatric symptom changes in youth |
| title_full_unstemmed | Exploring the longitudinal associations of functional network connectivity and psychiatric symptom changes in youth |
| title_short | Exploring the longitudinal associations of functional network connectivity and psychiatric symptom changes in youth |
| title_sort | exploring the longitudinal associations of functional network connectivity and psychiatric symptom changes in youth |
| topic | Functional MRI Psychopathology Adolescence Longitudinal studies Brain development |
| url | http://www.sciencedirect.com/science/article/pii/S2213158223000712 |
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