Systemic Diseases and Risk of Developing Gastrointestinal Cancer.
Importance: Gastrointestinal (GI) cancers are the second leading cause of cancer-related deaths worldwide. Observations: The global challenges GI cancers pose are high, especially in middle- and low-income countries. Patients with these cancers present with symptoms of poor appetite, weight loss, h...
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| Format: | Article |
| Language: | English |
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Shaukat Khanum Memorial Trust
2023-06-01
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| Series: | Journal of Cancer and Allied Specialties |
| Subjects: | |
| Online Access: | https://journals.sfu.ca/jcas/index.php/jcas/article/view/473 |
| _version_ | 1797745365110226944 |
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| author | Naila Malkani Muhammad Usman Rashid |
| author_facet | Naila Malkani Muhammad Usman Rashid |
| author_sort | Naila Malkani |
| collection | DOAJ |
| description |
Importance: Gastrointestinal (GI) cancers are the second leading cause of cancer-related deaths worldwide. Observations: The global challenges GI cancers pose are high, especially in middle- and low-income countries. Patients with these cancers present with symptoms of poor appetite, weight loss, heartburn, abdominal pain, fatigue, and anaemia. Several risk factors contribute to GI cancers, including age, gender, obesity, pathogenic infections, smoking cigarettes, alcohol consumption, and dietary habits. Most of these cancers are sporadic. However, some patients are at high risk because of a family history of GI cancers. Systemic diseases affect multiple organs, and their chronic occurrence elicits inflammatory responses at various sites. These diseases also contribute to GI cancers. Conclusion and Relevance: In this review, we discuss that untreated systemic diseases, including diabetes, hepatitis, AIDS, ulcers, and hypertension, can potentially lead to GI cancers if they remain untreated for a longer period. Systemic diseases initiate oxidative stress, inflammatory pathways, and genetic manipulations, which altogether confer risks to GI cancers. Here, we describe the association between systemic diseases and their underlying mechanisms leading to GI cancers.
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| first_indexed | 2024-03-12T15:22:12Z |
| format | Article |
| id | doaj.art-d52b4276e76141c4b68785c24ddaeb6b |
| institution | Directory Open Access Journal |
| issn | 2411-989X |
| language | English |
| last_indexed | 2024-03-12T15:22:12Z |
| publishDate | 2023-06-01 |
| publisher | Shaukat Khanum Memorial Trust |
| record_format | Article |
| series | Journal of Cancer and Allied Specialties |
| spelling | doaj.art-d52b4276e76141c4b68785c24ddaeb6b2023-08-11T01:21:12ZengShaukat Khanum Memorial TrustJournal of Cancer and Allied Specialties2411-989X2023-06-019210.37029/jcas.v9i2.473Systemic Diseases and Risk of Developing Gastrointestinal Cancer.Naila Malkani0Muhammad Usman Rashid1Department of Zoology, Government College University, Lahore, Punjab, PakistanDepartment of Basic Sciences Research, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Punjab, Pakistan Importance: Gastrointestinal (GI) cancers are the second leading cause of cancer-related deaths worldwide. Observations: The global challenges GI cancers pose are high, especially in middle- and low-income countries. Patients with these cancers present with symptoms of poor appetite, weight loss, heartburn, abdominal pain, fatigue, and anaemia. Several risk factors contribute to GI cancers, including age, gender, obesity, pathogenic infections, smoking cigarettes, alcohol consumption, and dietary habits. Most of these cancers are sporadic. However, some patients are at high risk because of a family history of GI cancers. Systemic diseases affect multiple organs, and their chronic occurrence elicits inflammatory responses at various sites. These diseases also contribute to GI cancers. Conclusion and Relevance: In this review, we discuss that untreated systemic diseases, including diabetes, hepatitis, AIDS, ulcers, and hypertension, can potentially lead to GI cancers if they remain untreated for a longer period. Systemic diseases initiate oxidative stress, inflammatory pathways, and genetic manipulations, which altogether confer risks to GI cancers. Here, we describe the association between systemic diseases and their underlying mechanisms leading to GI cancers. https://journals.sfu.ca/jcas/index.php/jcas/article/view/473Epidemiologygastrointestinal cancerglobal burdeninflammationrisk factorssystemic diseases |
| spellingShingle | Naila Malkani Muhammad Usman Rashid Systemic Diseases and Risk of Developing Gastrointestinal Cancer. Journal of Cancer and Allied Specialties Epidemiology gastrointestinal cancer global burden inflammation risk factors systemic diseases |
| title | Systemic Diseases and Risk of Developing Gastrointestinal Cancer. |
| title_full | Systemic Diseases and Risk of Developing Gastrointestinal Cancer. |
| title_fullStr | Systemic Diseases and Risk of Developing Gastrointestinal Cancer. |
| title_full_unstemmed | Systemic Diseases and Risk of Developing Gastrointestinal Cancer. |
| title_short | Systemic Diseases and Risk of Developing Gastrointestinal Cancer. |
| title_sort | systemic diseases and risk of developing gastrointestinal cancer |
| topic | Epidemiology gastrointestinal cancer global burden inflammation risk factors systemic diseases |
| url | https://journals.sfu.ca/jcas/index.php/jcas/article/view/473 |
| work_keys_str_mv | AT nailamalkani systemicdiseasesandriskofdevelopinggastrointestinalcancer AT muhammadusmanrashid systemicdiseasesandriskofdevelopinggastrointestinalcancer |