Ubiquitin Carboxyl-Terminal Hydrolases and Human Malignancies: The Novel Prognostic and Therapeutic Implications for Head and Neck Cancer
Ubiquitin C-terminal hydrolases (UCHs), a subfamily of deubiquitinating enzymes (DUBs), have been found in a variety of tumor entities and play distinct roles in the pathogenesis and development of various cancers including head and neck cancer (HNC). HNC is a heterogeneous disease arising from the...
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Frontiers Media S.A.
2021-01-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2020.592501/full |
| _version_ | 1818408101554946048 |
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| author | Chao Rong Chao Rong Ran Zhou Shan Wan Dan Su Shou-Li Wang Jochen Hess Jochen Hess |
| author_facet | Chao Rong Chao Rong Ran Zhou Shan Wan Dan Su Shou-Li Wang Jochen Hess Jochen Hess |
| author_sort | Chao Rong |
| collection | DOAJ |
| description | Ubiquitin C-terminal hydrolases (UCHs), a subfamily of deubiquitinating enzymes (DUBs), have been found in a variety of tumor entities and play distinct roles in the pathogenesis and development of various cancers including head and neck cancer (HNC). HNC is a heterogeneous disease arising from the mucosal epithelia of the upper aerodigestive tract, including different anatomic sites, distinct histopathologic types, as well as human papillomavirus (HPV)-positive and negative subgroups. Despite advances in multi-disciplinary treatment for HNC, the long-term survival rate of patients with HNC remains low. Emerging evidence has revealed the members of UCHs are associated with the pathogenesis and clinical prognosis of HNC, which highlights the prognostic and therapeutic implications of UCHs for patients with HNC. In this review, we summarize the physiological and pathological functions of the UCHs family, which provides enlightenment of potential mechanisms of UCHs family in HNC pathogenesis and highlights the potential consideration of UCHs as attractive drug targets. |
| first_indexed | 2024-12-14T09:38:23Z |
| format | Article |
| id | doaj.art-d52bcfa575fd4026a77ead37c1c18bad |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-14T09:38:23Z |
| publishDate | 2021-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Oncology |
| spelling | doaj.art-d52bcfa575fd4026a77ead37c1c18bad2022-12-21T23:07:52ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-01-011010.3389/fonc.2020.592501592501Ubiquitin Carboxyl-Terminal Hydrolases and Human Malignancies: The Novel Prognostic and Therapeutic Implications for Head and Neck CancerChao Rong0Chao Rong1Ran Zhou2Shan Wan3Dan Su4Shou-Li Wang5Jochen Hess6Jochen Hess7Department of Pathology, School of Biology & Basic Medical Sciences, Soochow University, Suzhou, ChinaSection Experimental and Translational Head and Neck Oncology, Department of Otolaryngology, Head and Neck Surgery, University Hospital Heidelberg, Heidelberg, GermanyDepartment of Pharmacy, The First Affiliated Hospital of University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, ChinaDepartment of Pathology, School of Biology & Basic Medical Sciences, Soochow University, Suzhou, ChinaDepartment of Pharmacy, The First Affiliated Hospital of University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, ChinaDepartment of Pathology, School of Biology & Basic Medical Sciences, Soochow University, Suzhou, ChinaSection Experimental and Translational Head and Neck Oncology, Department of Otolaryngology, Head and Neck Surgery, University Hospital Heidelberg, Heidelberg, GermanyResearch Group Molecular Mechanisms of Head and Neck Tumors, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, GermanyUbiquitin C-terminal hydrolases (UCHs), a subfamily of deubiquitinating enzymes (DUBs), have been found in a variety of tumor entities and play distinct roles in the pathogenesis and development of various cancers including head and neck cancer (HNC). HNC is a heterogeneous disease arising from the mucosal epithelia of the upper aerodigestive tract, including different anatomic sites, distinct histopathologic types, as well as human papillomavirus (HPV)-positive and negative subgroups. Despite advances in multi-disciplinary treatment for HNC, the long-term survival rate of patients with HNC remains low. Emerging evidence has revealed the members of UCHs are associated with the pathogenesis and clinical prognosis of HNC, which highlights the prognostic and therapeutic implications of UCHs for patients with HNC. In this review, we summarize the physiological and pathological functions of the UCHs family, which provides enlightenment of potential mechanisms of UCHs family in HNC pathogenesis and highlights the potential consideration of UCHs as attractive drug targets.https://www.frontiersin.org/articles/10.3389/fonc.2020.592501/fullhead and neck cancerubiquitin C-terminal hydrolasesdeubiquitinating enzymesgenomic alterationclinical relevance |
| spellingShingle | Chao Rong Chao Rong Ran Zhou Shan Wan Dan Su Shou-Li Wang Jochen Hess Jochen Hess Ubiquitin Carboxyl-Terminal Hydrolases and Human Malignancies: The Novel Prognostic and Therapeutic Implications for Head and Neck Cancer Frontiers in Oncology head and neck cancer ubiquitin C-terminal hydrolases deubiquitinating enzymes genomic alteration clinical relevance |
| title | Ubiquitin Carboxyl-Terminal Hydrolases and Human Malignancies: The Novel Prognostic and Therapeutic Implications for Head and Neck Cancer |
| title_full | Ubiquitin Carboxyl-Terminal Hydrolases and Human Malignancies: The Novel Prognostic and Therapeutic Implications for Head and Neck Cancer |
| title_fullStr | Ubiquitin Carboxyl-Terminal Hydrolases and Human Malignancies: The Novel Prognostic and Therapeutic Implications for Head and Neck Cancer |
| title_full_unstemmed | Ubiquitin Carboxyl-Terminal Hydrolases and Human Malignancies: The Novel Prognostic and Therapeutic Implications for Head and Neck Cancer |
| title_short | Ubiquitin Carboxyl-Terminal Hydrolases and Human Malignancies: The Novel Prognostic and Therapeutic Implications for Head and Neck Cancer |
| title_sort | ubiquitin carboxyl terminal hydrolases and human malignancies the novel prognostic and therapeutic implications for head and neck cancer |
| topic | head and neck cancer ubiquitin C-terminal hydrolases deubiquitinating enzymes genomic alteration clinical relevance |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2020.592501/full |
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