Ubiquitin Carboxyl-Terminal Hydrolases and Human Malignancies: The Novel Prognostic and Therapeutic Implications for Head and Neck Cancer

Ubiquitin Carboxyl-Terminal Hydrolases and Human Malignancies: The Novel Prognostic and Therapeutic Implications for Head and Neck Cancer

Ubiquitin C-terminal hydrolases (UCHs), a subfamily of deubiquitinating enzymes (DUBs), have been found in a variety of tumor entities and play distinct roles in the pathogenesis and development of various cancers including head and neck cancer (HNC). HNC is a heterogeneous disease arising from the...

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Bibliographic Details
Main Authors: Chao Rong, Ran Zhou, Shan Wan, Dan Su, Shou-Li Wang, Jochen Hess
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Oncology
Subjects:
head and neck cancer
ubiquitin C-terminal hydrolases
deubiquitinating enzymes
genomic alteration
clinical relevance
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.592501/full

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