Phagocytosis is a primary determinant of pulmonary clearance of clinical Klebsiella pneumoniae isolates

Phagocytosis is a primary determinant of pulmonary clearance of clinical Klebsiella pneumoniae isolates

IntroductionKlebsiella pneumoniae (Kp) is a common cause of hospital-acquired pneumonia. Although previous studies have suggested that evasion of phagocytic uptake is a virulence determinant of Kp, few studies have examined phagocytosis sensitivity in clinical Kp isolates.MethodsWe screened 19 clini...

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Bibliographic Details
Main Authors: Rick van der Geest, Hongye Fan, Hernán F. Peñaloza, William G. Bain, Zeyu Xiong, Naina Kohli, Emily Larson, Mara L. G. Sullivan, Jonathan M. Franks, Donna B. Stolz, Ryota Ito, Kong Chen, Yohei Doi, Melanie J. Harriff, Janet S. Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
respiratory infection
host defense
Klebsiella pneumoniae
phagocytosis
clinical isolates
macrophages
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2023.1150658/full

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