Association of PTGER4 and PRKAA1 genetic polymorphisms with gastric cancer
Abstract Background Gastric cancer (GC) is one of the most common malignancies, affected by several genetic loci in the clinical phenotype. This study aimed to determine the association between PTGER4 and PRKAA1 gene polymorphisms and the risk of GC. Methods A total of 509 GC patients and 507 age an...
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | BMC Medical Genomics |
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| Online Access: | https://doi.org/10.1186/s12920-023-01645-1 |
| _version_ | 1797555837770661888 |
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| author | Shuyong Yu Ruisha Tu Zhaowei Chen Jian Song Ping Li Feixiang Hu Guihong Yuan Ronglin Zhang Yini Li |
| author_facet | Shuyong Yu Ruisha Tu Zhaowei Chen Jian Song Ping Li Feixiang Hu Guihong Yuan Ronglin Zhang Yini Li |
| author_sort | Shuyong Yu |
| collection | DOAJ |
| description | Abstract Background Gastric cancer (GC) is one of the most common malignancies, affected by several genetic loci in the clinical phenotype. This study aimed to determine the association between PTGER4 and PRKAA1 gene polymorphisms and the risk of GC. Methods A total of 509 GC patients and 507 age and sex-matched healthy controls were recruited to explore the association between PTGER4 and PRKAA1 genetic polymorphisms and GC susceptibility. Logistic regression analysis was used to study the correlation between these SNPs and GC, with odd ratio (OR) and 95% confidence interval (CI) as indicators. Multifactor dimensionality reduction was utilized to analyze the genetic relationships among SNPs. was conducted to predict gene expression, the impact of SNPs on gene expression, and the signaling pathways involved in PTGER4 and PRKAA1. Results Overall, rs10036575 in PTGER4 (OR = 0.82, p = 0.029), rs10074991 (OR = 0.82, p = 0.024) and rs13361707 (OR = 0.82, p = 0.030) in PRKAA1 were associated with susceptibility to GC. Stratification analysis revealed that the effects of these SNPs in PTGER4 and PRKAA1 on GC susceptibility were dependent on smoking and were associated with a reduced risk of adenocarcinoma (p < 0.05). Bioinformatics analysis showed an association between SNPs and corresponding gene expression (p < 0.05), and PRKAA1 may affect GC by mediating RhoA. Conclusion This study suggests that PTGER4 and PRKAA1 SNPs might affect the susceptibility of GC, providing a new biological perspective for GC risk assessment, pathogenesis exploration, and personalized treatment. |
| first_indexed | 2024-03-10T16:54:23Z |
| format | Article |
| id | doaj.art-d52da1143dfa4ac9af262b24c331d647 |
| institution | Directory Open Access Journal |
| issn | 1755-8794 |
| language | English |
| last_indexed | 2024-03-10T16:54:23Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medical Genomics |
| spelling | doaj.art-d52da1143dfa4ac9af262b24c331d6472023-11-20T11:13:10ZengBMCBMC Medical Genomics1755-87942023-09-0116111110.1186/s12920-023-01645-1Association of PTGER4 and PRKAA1 genetic polymorphisms with gastric cancerShuyong Yu0Ruisha Tu1Zhaowei Chen2Jian Song3Ping Li4Feixiang Hu5Guihong Yuan6Ronglin Zhang7Yini Li8Department of Gastrointestinal Surgery, Hainan Cancer HospitalDepartment of Gastrointestinal Surgery, Hainan Cancer HospitalDepartment of Gastroenterology, Southern University of Science and Technology HospitalDepartment of Gastroenterology, Southern University of Science and Technology HospitalDepartment of Digestive Endoscopy, Hainan Cancer HospitalDepartment of Gastrointestinal Surgery, Hainan Cancer HospitalDepartment of Gastroenterology, Southern University of Science and Technology HospitalDepartment of Digestive Endoscopy, Hainan Cancer HospitalDepartment of Digestive Endoscopy, Hainan Cancer HospitalAbstract Background Gastric cancer (GC) is one of the most common malignancies, affected by several genetic loci in the clinical phenotype. This study aimed to determine the association between PTGER4 and PRKAA1 gene polymorphisms and the risk of GC. Methods A total of 509 GC patients and 507 age and sex-matched healthy controls were recruited to explore the association between PTGER4 and PRKAA1 genetic polymorphisms and GC susceptibility. Logistic regression analysis was used to study the correlation between these SNPs and GC, with odd ratio (OR) and 95% confidence interval (CI) as indicators. Multifactor dimensionality reduction was utilized to analyze the genetic relationships among SNPs. was conducted to predict gene expression, the impact of SNPs on gene expression, and the signaling pathways involved in PTGER4 and PRKAA1. Results Overall, rs10036575 in PTGER4 (OR = 0.82, p = 0.029), rs10074991 (OR = 0.82, p = 0.024) and rs13361707 (OR = 0.82, p = 0.030) in PRKAA1 were associated with susceptibility to GC. Stratification analysis revealed that the effects of these SNPs in PTGER4 and PRKAA1 on GC susceptibility were dependent on smoking and were associated with a reduced risk of adenocarcinoma (p < 0.05). Bioinformatics analysis showed an association between SNPs and corresponding gene expression (p < 0.05), and PRKAA1 may affect GC by mediating RhoA. Conclusion This study suggests that PTGER4 and PRKAA1 SNPs might affect the susceptibility of GC, providing a new biological perspective for GC risk assessment, pathogenesis exploration, and personalized treatment.https://doi.org/10.1186/s12920-023-01645-1Gastric cancerPTGER4 polymorphismsPRKAA1 polymorphismsStratification analysis |
| spellingShingle | Shuyong Yu Ruisha Tu Zhaowei Chen Jian Song Ping Li Feixiang Hu Guihong Yuan Ronglin Zhang Yini Li Association of PTGER4 and PRKAA1 genetic polymorphisms with gastric cancer BMC Medical Genomics Gastric cancer PTGER4 polymorphisms PRKAA1 polymorphisms Stratification analysis |
| title | Association of PTGER4 and PRKAA1 genetic polymorphisms with gastric cancer |
| title_full | Association of PTGER4 and PRKAA1 genetic polymorphisms with gastric cancer |
| title_fullStr | Association of PTGER4 and PRKAA1 genetic polymorphisms with gastric cancer |
| title_full_unstemmed | Association of PTGER4 and PRKAA1 genetic polymorphisms with gastric cancer |
| title_short | Association of PTGER4 and PRKAA1 genetic polymorphisms with gastric cancer |
| title_sort | association of ptger4 and prkaa1 genetic polymorphisms with gastric cancer |
| topic | Gastric cancer PTGER4 polymorphisms PRKAA1 polymorphisms Stratification analysis |
| url | https://doi.org/10.1186/s12920-023-01645-1 |
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