Evaluating corneal changes after corneal collagen cross-linking in keratoconus by optical coherence tomography
Purpose The aim of this study was to evaluate the corneal changes after corneal collagen cross-linking (CXL) in progressive keratoconus using anterior segment optical coherence tomography. Patients and methods This prospective interventional noncomparative case-series study was conducted on 30 eyes...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Delta Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.djo.eg.net/article.asp?issn=1110-9173;year=2022;volume=23;issue=3;spage=149;epage=156;aulast=Barakat |
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| author | Abdallah Barakat Ahmed Elmassry Ihab Othman Mohamed El-Kateb |
| author_facet | Abdallah Barakat Ahmed Elmassry Ihab Othman Mohamed El-Kateb |
| author_sort | Abdallah Barakat |
| collection | DOAJ |
| description | Purpose The aim of this study was to evaluate the corneal changes after corneal collagen cross-linking (CXL) in progressive keratoconus using anterior segment optical coherence tomography.
Patients and methods This prospective interventional noncomparative case-series study was conducted on 30 eyes of 18 patients of both sexes with a mean age of 23.11±4.06 years diagnosed as progressive keratoconus patients with clear central cornea. All eyes underwent epithelium-off accelerated CXL. Anterior segment optical coherence tomography and Scheimpflug camera imaging were done to all cases preoperatively and at 1, 3, and 6 months, postoperatively.
Results The demarcation line (DL) was detected in all eyes 1 month postoperatively, and was still detected at 3 and 6 months, postoperatively. However, it was accurately measured until 3 months postoperatively. At 6 months, it was barely visible, so measuring its depth was difficult to be done. There was a statistically significant positive correlation between the thinnest corneal thickness and the central corneal DL depth (r=0.480, P=0.006). There was no statistically significant correlation between the maximum keratometric reading (K-max) and the depth of central corneal DL (r=−0.253, P=0.17). In addition, there was no statistically significant correlation between corneal densitometry and the depth of central corneal DL (r=−0.68, P=0.715).
Conclusions The DL is a direct clinical sign of corneal CXL and can be found within 6 months after the treatment, being most clearly visible at 1 month after CXL. However, the line starts to be less visible after 3 months and becomes barely visible after 6 months postoperatively, making it difficult to measure its depth at that time. |
| first_indexed | 2024-04-13T10:50:37Z |
| format | Article |
| id | doaj.art-d52ebc1369bb42d299773f91db311bc5 |
| institution | Directory Open Access Journal |
| issn | 1110-9173 2090-4835 |
| language | English |
| last_indexed | 2024-04-13T10:50:37Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Delta Journal of Ophthalmology |
| spelling | doaj.art-d52ebc1369bb42d299773f91db311bc52022-12-22T02:49:40ZengWolters Kluwer Medknow PublicationsDelta Journal of Ophthalmology1110-91732090-48352022-01-0123314915610.1353/djo_12_22Evaluating corneal changes after corneal collagen cross-linking in keratoconus by optical coherence tomographyAbdallah BarakatAhmed ElmassryIhab OthmanMohamed El-KatebPurpose The aim of this study was to evaluate the corneal changes after corneal collagen cross-linking (CXL) in progressive keratoconus using anterior segment optical coherence tomography. Patients and methods This prospective interventional noncomparative case-series study was conducted on 30 eyes of 18 patients of both sexes with a mean age of 23.11±4.06 years diagnosed as progressive keratoconus patients with clear central cornea. All eyes underwent epithelium-off accelerated CXL. Anterior segment optical coherence tomography and Scheimpflug camera imaging were done to all cases preoperatively and at 1, 3, and 6 months, postoperatively. Results The demarcation line (DL) was detected in all eyes 1 month postoperatively, and was still detected at 3 and 6 months, postoperatively. However, it was accurately measured until 3 months postoperatively. At 6 months, it was barely visible, so measuring its depth was difficult to be done. There was a statistically significant positive correlation between the thinnest corneal thickness and the central corneal DL depth (r=0.480, P=0.006). There was no statistically significant correlation between the maximum keratometric reading (K-max) and the depth of central corneal DL (r=−0.253, P=0.17). In addition, there was no statistically significant correlation between corneal densitometry and the depth of central corneal DL (r=−0.68, P=0.715). Conclusions The DL is a direct clinical sign of corneal CXL and can be found within 6 months after the treatment, being most clearly visible at 1 month after CXL. However, the line starts to be less visible after 3 months and becomes barely visible after 6 months postoperatively, making it difficult to measure its depth at that time.http://www.djo.eg.net/article.asp?issn=1110-9173;year=2022;volume=23;issue=3;spage=149;epage=156;aulast=Barakatanterior segment-octcorneal cross-linkingdemarcation line |
| spellingShingle | Abdallah Barakat Ahmed Elmassry Ihab Othman Mohamed El-Kateb Evaluating corneal changes after corneal collagen cross-linking in keratoconus by optical coherence tomography Delta Journal of Ophthalmology anterior segment-oct corneal cross-linking demarcation line |
| title | Evaluating corneal changes after corneal collagen cross-linking in keratoconus by optical coherence tomography |
| title_full | Evaluating corneal changes after corneal collagen cross-linking in keratoconus by optical coherence tomography |
| title_fullStr | Evaluating corneal changes after corneal collagen cross-linking in keratoconus by optical coherence tomography |
| title_full_unstemmed | Evaluating corneal changes after corneal collagen cross-linking in keratoconus by optical coherence tomography |
| title_short | Evaluating corneal changes after corneal collagen cross-linking in keratoconus by optical coherence tomography |
| title_sort | evaluating corneal changes after corneal collagen cross linking in keratoconus by optical coherence tomography |
| topic | anterior segment-oct corneal cross-linking demarcation line |
| url | http://www.djo.eg.net/article.asp?issn=1110-9173;year=2022;volume=23;issue=3;spage=149;epage=156;aulast=Barakat |
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