Identification of NAPRT Inhibitors with Anti-Cancer Properties by In Silico Drug Discovery

Identification of NAPRT Inhibitors with Anti-Cancer Properties by In Silico Drug Discovery

Depriving cancer cells of sufficient NAD levels, mainly through interfering with their NAD-producing capacity, has been conceived as a promising anti-cancer strategy. Numerous inhibitors of the NAD-producing enzyme, nicotinamide phosphoribosyltransferase (NAMPT), have been developed over the past tw...

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Bibliographic Details
Main Authors: Moustafa S. Ghanem, Irene Caffa, Alberto Del Rio, Jorge Franco, Marco Daniele Parenti, Fiammetta Monacelli, Michele Cea, Amr Khalifa, Aimable Nahimana, Michel A. Duchosal, Silvia Ravera, Nadia Bertola, Santina Bruzzone, Alessio Nencioni, Francesco Piacente
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Pharmaceuticals
Subjects:
NAPRT inhibitors
cancer metabolism
NAD
anti-cancer agents
NAMPT
NAD synthesis
Online Access:https://www.mdpi.com/1424-8247/15/7/848

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