Antioxidant and anti-inflammatory activity of curcumin transdermal gel in an IL-10 knockout mouse model of inflammatory bowel disease
Abstract Inflammatory bowel diseases are a group of inflammatory disorders of the gastrointestinal tract. Their prevalence is still low in Brazil, but the incidence is increasing annually. A variety of compounds present in Curcuma longa L., particularly curcumin, have been shown to reduce oxidative...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Academia Brasileira de Ciências
2022-12-01
|
| Series: | Anais da Academia Brasileira de Ciências |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652022000600704&tlng=en |
| _version_ | 1811212715892408320 |
|---|---|
| author | FERNANDA O. ARAUJO MATHEUS B. FELÍCIO CÁSSIO F. LIMA MAYRA S. PICCOLO VIRGÍNIA R. PIZZIOLO GASPAR DIAZ-MUÑOZ DANIEL S.S. BASTOS LEANDRO L. OLIVEIRA MARIA DO C.G. PELUZIO MARISA A.N. DIAZ |
| author_facet | FERNANDA O. ARAUJO MATHEUS B. FELÍCIO CÁSSIO F. LIMA MAYRA S. PICCOLO VIRGÍNIA R. PIZZIOLO GASPAR DIAZ-MUÑOZ DANIEL S.S. BASTOS LEANDRO L. OLIVEIRA MARIA DO C.G. PELUZIO MARISA A.N. DIAZ |
| author_sort | FERNANDA O. ARAUJO |
| collection | DOAJ |
| description | Abstract Inflammatory bowel diseases are a group of inflammatory disorders of the gastrointestinal tract. Their prevalence is still low in Brazil, but the incidence is increasing annually. A variety of compounds present in Curcuma longa L., particularly curcumin, have been shown to reduce oxidative stress and aid in the prevention of associated diseases. This study aimed to assess the effect of curcumin transdermal gel on oxidative stress and intestinal inflammation in IL-10 knockout mice. Female mice were divided into four groups: a control group (C0) treated with vehicle and three experimental groups treated with transdermal gel containing 50 (C50), 75 (C75), and 100 (C100) mg curcumin kg−1 body weight. Colon malondialdehyde concentrations were lower in C50 and C75 groups. C100 treatment led to reduced catalase activity in the small intestine, whereas C50, C75, and C100 treatments resulted in decreased catalase activity in the colon. In contrast, superoxide dismutase activity increased in the small intestine of C50 and C75 mice and decreased in the colon of C50, C75, and C100 mice. Glutathione S-transferase activity increased in the small intestine and decreased in the colon of C75 animals. These findings suggest that curcumin transdermal gel exerts a protective effect against oxidative stress. |
| first_indexed | 2024-04-12T05:33:48Z |
| format | Article |
| id | doaj.art-d531319851fe494c9a139d9776d34f61 |
| institution | Directory Open Access Journal |
| issn | 1678-2690 |
| language | English |
| last_indexed | 2024-04-12T05:33:48Z |
| publishDate | 2022-12-01 |
| publisher | Academia Brasileira de Ciências |
| record_format | Article |
| series | Anais da Academia Brasileira de Ciências |
| spelling | doaj.art-d531319851fe494c9a139d9776d34f612022-12-22T03:45:56ZengAcademia Brasileira de CiênciasAnais da Academia Brasileira de Ciências1678-26902022-12-0194410.1590/0001-3765202220201378Antioxidant and anti-inflammatory activity of curcumin transdermal gel in an IL-10 knockout mouse model of inflammatory bowel diseaseFERNANDA O. ARAUJOhttps://orcid.org/0000-0001-7420-9614MATHEUS B. FELÍCIOhttps://orcid.org/0000-0001-7369-9025CÁSSIO F. LIMAhttps://orcid.org/0000-0001-5461-1809MAYRA S. PICCOLOhttps://orcid.org/0000-0001-7873-4977VIRGÍNIA R. PIZZIOLOhttps://orcid.org/0000-0001-8611-4663GASPAR DIAZ-MUÑOZhttps://orcid.org/0000-0002-7515-0420DANIEL S.S. BASTOShttps://orcid.org/0000-0001-7442-8067LEANDRO L. OLIVEIRAhttps://orcid.org/0000-0003-4353-7011MARIA DO C.G. PELUZIOhttps://orcid.org/0000-0003-4665-7043MARISA A.N. DIAZhttps://orcid.org/0000-0002-3370-4149Abstract Inflammatory bowel diseases are a group of inflammatory disorders of the gastrointestinal tract. Their prevalence is still low in Brazil, but the incidence is increasing annually. A variety of compounds present in Curcuma longa L., particularly curcumin, have been shown to reduce oxidative stress and aid in the prevention of associated diseases. This study aimed to assess the effect of curcumin transdermal gel on oxidative stress and intestinal inflammation in IL-10 knockout mice. Female mice were divided into four groups: a control group (C0) treated with vehicle and three experimental groups treated with transdermal gel containing 50 (C50), 75 (C75), and 100 (C100) mg curcumin kg−1 body weight. Colon malondialdehyde concentrations were lower in C50 and C75 groups. C100 treatment led to reduced catalase activity in the small intestine, whereas C50, C75, and C100 treatments resulted in decreased catalase activity in the colon. In contrast, superoxide dismutase activity increased in the small intestine of C50 and C75 mice and decreased in the colon of C50, C75, and C100 mice. Glutathione S-transferase activity increased in the small intestine and decreased in the colon of C75 animals. These findings suggest that curcumin transdermal gel exerts a protective effect against oxidative stress.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652022000600704&tlng=enIntestinal inflammationhistologyoxidative stresscurcumin |
| spellingShingle | FERNANDA O. ARAUJO MATHEUS B. FELÍCIO CÁSSIO F. LIMA MAYRA S. PICCOLO VIRGÍNIA R. PIZZIOLO GASPAR DIAZ-MUÑOZ DANIEL S.S. BASTOS LEANDRO L. OLIVEIRA MARIA DO C.G. PELUZIO MARISA A.N. DIAZ Antioxidant and anti-inflammatory activity of curcumin transdermal gel in an IL-10 knockout mouse model of inflammatory bowel disease Anais da Academia Brasileira de Ciências Intestinal inflammation histology oxidative stress curcumin |
| title | Antioxidant and anti-inflammatory activity of curcumin transdermal gel in an IL-10 knockout mouse model of inflammatory bowel disease |
| title_full | Antioxidant and anti-inflammatory activity of curcumin transdermal gel in an IL-10 knockout mouse model of inflammatory bowel disease |
| title_fullStr | Antioxidant and anti-inflammatory activity of curcumin transdermal gel in an IL-10 knockout mouse model of inflammatory bowel disease |
| title_full_unstemmed | Antioxidant and anti-inflammatory activity of curcumin transdermal gel in an IL-10 knockout mouse model of inflammatory bowel disease |
| title_short | Antioxidant and anti-inflammatory activity of curcumin transdermal gel in an IL-10 knockout mouse model of inflammatory bowel disease |
| title_sort | antioxidant and anti inflammatory activity of curcumin transdermal gel in an il 10 knockout mouse model of inflammatory bowel disease |
| topic | Intestinal inflammation histology oxidative stress curcumin |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652022000600704&tlng=en |
| work_keys_str_mv | AT fernandaoaraujo antioxidantandantiinflammatoryactivityofcurcumintransdermalgelinanil10knockoutmousemodelofinflammatoryboweldisease AT matheusbfelicio antioxidantandantiinflammatoryactivityofcurcumintransdermalgelinanil10knockoutmousemodelofinflammatoryboweldisease AT cassioflima antioxidantandantiinflammatoryactivityofcurcumintransdermalgelinanil10knockoutmousemodelofinflammatoryboweldisease AT mayraspiccolo antioxidantandantiinflammatoryactivityofcurcumintransdermalgelinanil10knockoutmousemodelofinflammatoryboweldisease AT virginiarpizziolo antioxidantandantiinflammatoryactivityofcurcumintransdermalgelinanil10knockoutmousemodelofinflammatoryboweldisease AT gaspardiazmunoz antioxidantandantiinflammatoryactivityofcurcumintransdermalgelinanil10knockoutmousemodelofinflammatoryboweldisease AT danielssbastos antioxidantandantiinflammatoryactivityofcurcumintransdermalgelinanil10knockoutmousemodelofinflammatoryboweldisease AT leandrololiveira antioxidantandantiinflammatoryactivityofcurcumintransdermalgelinanil10knockoutmousemodelofinflammatoryboweldisease AT mariadocgpeluzio antioxidantandantiinflammatoryactivityofcurcumintransdermalgelinanil10knockoutmousemodelofinflammatoryboweldisease AT marisaandiaz antioxidantandantiinflammatoryactivityofcurcumintransdermalgelinanil10knockoutmousemodelofinflammatoryboweldisease |