Losmapimod Protected Epileptic Rats From Hippocampal Neuron Damage Through Inhibition of the MAPK Pathway

Losmapimod Protected Epileptic Rats From Hippocampal Neuron Damage Through Inhibition of the MAPK Pathway

Objective: This research aimed to validate the therapeutic effect of losmapimod and explore the underlying mechanism in its treatment of epilepsy.Methods: A rat model of epilepsy was constructed with an injection of pilocarpine. Microarray analysis was performed to screen aberrantly expressed mRNAs...

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Bibliographic Details
Main Authors: Min Li, Lexiang Cui, Xuemin Feng, Chao Wang, Yinmeng Zhang, Lijie Wang, Ying Ding, Teng Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Pharmacology
Subjects:
losmapimod
mitogen-activated protein kinase
epilepsy
hippocampus
pilocarpine
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00625/full

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