Liver Fibrosis and Inflammation under the Control of ERK2
Chronic liver injury could lead the formation of liver fibrosis, eventually some would develop to hepatocellular carcinoma (HCC), one of the leading malignancies worldwide. The aim of the study is to dissect the role of extracellular signal-regulated kinase 2 (ERK2) signaling in liver fibrosis and i...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/11/3796 |
| _version_ | 1797566911074009088 |
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| author | Kuo-Shyang Jeng Ssu-Jung Lu Chih-Hsuan Wang Chiung-Fang Chang |
| author_facet | Kuo-Shyang Jeng Ssu-Jung Lu Chih-Hsuan Wang Chiung-Fang Chang |
| author_sort | Kuo-Shyang Jeng |
| collection | DOAJ |
| description | Chronic liver injury could lead the formation of liver fibrosis, eventually some would develop to hepatocellular carcinoma (HCC), one of the leading malignancies worldwide. The aim of the study is to dissect the role of extracellular signal-regulated kinase 2 (ERK2) signaling in liver fibrosis and inflammation. The choline-deficient, ethionine-supplemented (CDE) diet could lead to fatty livers and generate oval cells, activate hepatocyte stellate cell (HSC) and recruit immune cells as the liver fibrosis model mice. WT and ERK2 deficient (ERK2<sup>−/−</sup>) mice were compared in terms of liver weight/body weight, liver function, liver fibrosis markers and the differential gene expression in hepatotoxicity. ERK2<sup>−/−</sup> mice display the less degree of liver fibrosis when compared to WT mice. The protein level of alpha smooth muscle (α-SMA) was reduced and several hepatocellular carcinoma-related genes such as MMP9, FoxM1 were down-regulated. In addition, the cell proliferation and the percentages of activated T cells were reduced in ERK2<sup>−/−</sup> mice upon liver injury. Therefore, ERK2 plays an important role in regulating liver cirrhosis and inflammation. |
| first_indexed | 2024-03-10T19:34:07Z |
| format | Article |
| id | doaj.art-d532421dd6a345d78f9962ba3a73b3e2 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T19:34:07Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-d532421dd6a345d78f9962ba3a73b3e22023-11-20T01:56:03ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-05-012111379610.3390/ijms21113796Liver Fibrosis and Inflammation under the Control of ERK2Kuo-Shyang Jeng0Ssu-Jung Lu1Chih-Hsuan Wang2Chiung-Fang Chang3Division of General Surgery and Department of Medical Research, Far Eastern Memorial Hospital, No.21, Sec. 2, Nanya S. Rd., Banciao Dist., New Taipei City 220, TaiwanDivision of General Surgery and Department of Medical Research, Far Eastern Memorial Hospital, No.21, Sec. 2, Nanya S. Rd., Banciao Dist., New Taipei City 220, TaiwanDivision of General Surgery and Department of Medical Research, Far Eastern Memorial Hospital, No.21, Sec. 2, Nanya S. Rd., Banciao Dist., New Taipei City 220, TaiwanDivision of General Surgery and Department of Medical Research, Far Eastern Memorial Hospital, No.21, Sec. 2, Nanya S. Rd., Banciao Dist., New Taipei City 220, TaiwanChronic liver injury could lead the formation of liver fibrosis, eventually some would develop to hepatocellular carcinoma (HCC), one of the leading malignancies worldwide. The aim of the study is to dissect the role of extracellular signal-regulated kinase 2 (ERK2) signaling in liver fibrosis and inflammation. The choline-deficient, ethionine-supplemented (CDE) diet could lead to fatty livers and generate oval cells, activate hepatocyte stellate cell (HSC) and recruit immune cells as the liver fibrosis model mice. WT and ERK2 deficient (ERK2<sup>−/−</sup>) mice were compared in terms of liver weight/body weight, liver function, liver fibrosis markers and the differential gene expression in hepatotoxicity. ERK2<sup>−/−</sup> mice display the less degree of liver fibrosis when compared to WT mice. The protein level of alpha smooth muscle (α-SMA) was reduced and several hepatocellular carcinoma-related genes such as MMP9, FoxM1 were down-regulated. In addition, the cell proliferation and the percentages of activated T cells were reduced in ERK2<sup>−/−</sup> mice upon liver injury. Therefore, ERK2 plays an important role in regulating liver cirrhosis and inflammation.https://www.mdpi.com/1422-0067/21/11/3796ERK2MAPKliver cirrhosisliver inflammation |
| spellingShingle | Kuo-Shyang Jeng Ssu-Jung Lu Chih-Hsuan Wang Chiung-Fang Chang Liver Fibrosis and Inflammation under the Control of ERK2 International Journal of Molecular Sciences ERK2 MAPK liver cirrhosis liver inflammation |
| title | Liver Fibrosis and Inflammation under the Control of ERK2 |
| title_full | Liver Fibrosis and Inflammation under the Control of ERK2 |
| title_fullStr | Liver Fibrosis and Inflammation under the Control of ERK2 |
| title_full_unstemmed | Liver Fibrosis and Inflammation under the Control of ERK2 |
| title_short | Liver Fibrosis and Inflammation under the Control of ERK2 |
| title_sort | liver fibrosis and inflammation under the control of erk2 |
| topic | ERK2 MAPK liver cirrhosis liver inflammation |
| url | https://www.mdpi.com/1422-0067/21/11/3796 |
| work_keys_str_mv | AT kuoshyangjeng liverfibrosisandinflammationunderthecontroloferk2 AT ssujunglu liverfibrosisandinflammationunderthecontroloferk2 AT chihhsuanwang liverfibrosisandinflammationunderthecontroloferk2 AT chiungfangchang liverfibrosisandinflammationunderthecontroloferk2 |