Design of Two New Sulfur Derivatives of Perezone: In Silico Study Simulation Targeting PARP-1 and In Vitro Study Validation Using Cancer Cell Lines

Design of Two New Sulfur Derivatives of Perezone: In Silico Study Simulation Targeting PARP-1 and In Vitro Study Validation Using Cancer Cell Lines

Poly-ADP-Ribose Polymerase (PARP-1) is an overexpressed enzyme in several carcinomas; consequently, the design of PARP-1 inhibitors has acquired special attention. Hence, in the present study, three compounds (<b>8</b>–<b>10</b>) were produced through a Michael addition proto...

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Bibliographic Details
Main Authors: Alejandro Rubiales-Martínez, Joel Martínez, Elvia Mera-Jiménez, Javier Pérez-Flores, Guillermo Téllez-Isaías, René Miranda Ruvalcaba, Maricarmen Hernández-Rodríguez, Teresa Mancilla Percino, Martha Edith Macías Pérez, María Inés Nicolás-Vázquez
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:International Journal of Molecular Sciences
Subjects:
perezone
sulfur derivates
natural products
cytotoxic activity
DFT
PARP-1
Online Access:https://www.mdpi.com/1422-0067/25/2/868

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