Endoscopic Ultrasound Guided Fine Needle Aspiration versus Endoscopic Ultrasound Guided Fine Needle Biopsy for Pancreatic Cancer Diagnosis: A Systematic Review and Meta-Analysis
Introduction: One of the most effective diagnostic tools for pancreatic cancer is endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) or biopsy (EUS-FNB). Several randomized clinical trials have compared different EUS tissue sampling needles for the diagnosis of pancreatic cancer. Objectiv...
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| Format: | Article |
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MDPI AG
2022-11-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/12/2951 |
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| author | Galab M. Hassan Louise Laporte Sarto C. Paquin Charles Menard Anand V. Sahai Benoît Mâsse Helen Trottier |
| author_facet | Galab M. Hassan Louise Laporte Sarto C. Paquin Charles Menard Anand V. Sahai Benoît Mâsse Helen Trottier |
| author_sort | Galab M. Hassan |
| collection | DOAJ |
| description | Introduction: One of the most effective diagnostic tools for pancreatic cancer is endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) or biopsy (EUS-FNB). Several randomized clinical trials have compared different EUS tissue sampling needles for the diagnosis of pancreatic cancer. Objective: To compare the diagnostic accuracy of EUS-guided FNA as EUS-FNB needles for the diagnosis of pancreatic cancer using a systematic review and meta-analysis. Method: A literature review with a meta-analysis was performed according to the PRISMA guide. The databases of PubMed, Cochrane and Google Scholar were used, including studies published between 2011–2021 comparing the diagnostic yield (diagnostic accuracy or probability of positivity, sensitivity, specificity, predictive value) of EUS-FNA and EUS-FNB for the diagnosis of pancreatic cancer. The primary outcome was diagnostic accuracy. Random effect models allowed estimation of the pooled odds ratio with a confidence interval (CI) of 95%. Results: Nine randomized control trials were selected out of 5802 articles identified. Among these, five studies found no statistically significant difference between the EUS-FNA and EUS-FNB, whereas the other four did. The meta-analysis found EUS-FNB accuracy superior to EUS-FNA for the diagnosis of pancreatic cancer with a pooled odds ratio of 1.87 (IC 95%: 1.33–2.63). Conclusion: As compared to EUS-FNA, EUS-FNB seems to improve diagnostic accuracy when applied to suspicious pancreatic lesions. |
| first_indexed | 2024-03-09T17:08:45Z |
| format | Article |
| id | doaj.art-d533828dcfd64ee39642b3415a43d538 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T17:08:45Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-d533828dcfd64ee39642b3415a43d5382023-11-24T14:16:03ZengMDPI AGDiagnostics2075-44182022-11-011212295110.3390/diagnostics12122951Endoscopic Ultrasound Guided Fine Needle Aspiration versus Endoscopic Ultrasound Guided Fine Needle Biopsy for Pancreatic Cancer Diagnosis: A Systematic Review and Meta-AnalysisGalab M. Hassan0Louise Laporte1Sarto C. Paquin2Charles Menard3Anand V. Sahai4Benoît Mâsse5Helen Trottier6Division of Gastroenterology, Department of Medicine, Réseau Hospitalier Neuchâtelois, 2000 Neuchâtel, SwitzerlandResearch Center, CHU Sainte-Justine, Montreal, QC H3T 1C5, CanadaDepartment of Gastroenterology, Centre Hospitalier de l’Université de Montréal, Montreal, QC H2X 3E4, CanadaDepartment of Gastroenterology, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC J1H 4C6, CanadaDepartment of Gastroenterology, Centre Hospitalier de l’Université de Montréal, Montreal, QC H2X 3E4, CanadaSchool of Public Health, Université de Montréal, Montreal, QC H3T 1C5, CanadaSchool of Public Health, Université de Montréal, Montreal, QC H3T 1C5, CanadaIntroduction: One of the most effective diagnostic tools for pancreatic cancer is endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) or biopsy (EUS-FNB). Several randomized clinical trials have compared different EUS tissue sampling needles for the diagnosis of pancreatic cancer. Objective: To compare the diagnostic accuracy of EUS-guided FNA as EUS-FNB needles for the diagnosis of pancreatic cancer using a systematic review and meta-analysis. Method: A literature review with a meta-analysis was performed according to the PRISMA guide. The databases of PubMed, Cochrane and Google Scholar were used, including studies published between 2011–2021 comparing the diagnostic yield (diagnostic accuracy or probability of positivity, sensitivity, specificity, predictive value) of EUS-FNA and EUS-FNB for the diagnosis of pancreatic cancer. The primary outcome was diagnostic accuracy. Random effect models allowed estimation of the pooled odds ratio with a confidence interval (CI) of 95%. Results: Nine randomized control trials were selected out of 5802 articles identified. Among these, five studies found no statistically significant difference between the EUS-FNA and EUS-FNB, whereas the other four did. The meta-analysis found EUS-FNB accuracy superior to EUS-FNA for the diagnosis of pancreatic cancer with a pooled odds ratio of 1.87 (IC 95%: 1.33–2.63). Conclusion: As compared to EUS-FNA, EUS-FNB seems to improve diagnostic accuracy when applied to suspicious pancreatic lesions.https://www.mdpi.com/2075-4418/12/12/2951fine-needle aspirationfine-needle biopsypancreatic cancerdiagnostic accuracy |
| spellingShingle | Galab M. Hassan Louise Laporte Sarto C. Paquin Charles Menard Anand V. Sahai Benoît Mâsse Helen Trottier Endoscopic Ultrasound Guided Fine Needle Aspiration versus Endoscopic Ultrasound Guided Fine Needle Biopsy for Pancreatic Cancer Diagnosis: A Systematic Review and Meta-Analysis Diagnostics fine-needle aspiration fine-needle biopsy pancreatic cancer diagnostic accuracy |
| title | Endoscopic Ultrasound Guided Fine Needle Aspiration versus Endoscopic Ultrasound Guided Fine Needle Biopsy for Pancreatic Cancer Diagnosis: A Systematic Review and Meta-Analysis |
| title_full | Endoscopic Ultrasound Guided Fine Needle Aspiration versus Endoscopic Ultrasound Guided Fine Needle Biopsy for Pancreatic Cancer Diagnosis: A Systematic Review and Meta-Analysis |
| title_fullStr | Endoscopic Ultrasound Guided Fine Needle Aspiration versus Endoscopic Ultrasound Guided Fine Needle Biopsy for Pancreatic Cancer Diagnosis: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Endoscopic Ultrasound Guided Fine Needle Aspiration versus Endoscopic Ultrasound Guided Fine Needle Biopsy for Pancreatic Cancer Diagnosis: A Systematic Review and Meta-Analysis |
| title_short | Endoscopic Ultrasound Guided Fine Needle Aspiration versus Endoscopic Ultrasound Guided Fine Needle Biopsy for Pancreatic Cancer Diagnosis: A Systematic Review and Meta-Analysis |
| title_sort | endoscopic ultrasound guided fine needle aspiration versus endoscopic ultrasound guided fine needle biopsy for pancreatic cancer diagnosis a systematic review and meta analysis |
| topic | fine-needle aspiration fine-needle biopsy pancreatic cancer diagnostic accuracy |
| url | https://www.mdpi.com/2075-4418/12/12/2951 |
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