Association between exercise habit changes and incident dementia after ischemic stroke
Abstract We aimed to investigate the effects of exercise habit changes on the risk of incident dementia after ischemic stroke using the Korean National Health Insurance Services Database. This study included 223,426 patients with a new diagnosis of ischemic stroke between 2010 and 2016 who underwent...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-03-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-31229-z |
| _version_ | 1797864863009079296 |
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| author | Dae Young Cheon Kyung do Han Chi-hun Kim Mi Sun Oh Byung-Chul Lee Yerim Kim Sang-Hwa Lee Chulho Kim Jae-Sung Lim Minwoo Lee Kyung-Ho Yu |
| author_facet | Dae Young Cheon Kyung do Han Chi-hun Kim Mi Sun Oh Byung-Chul Lee Yerim Kim Sang-Hwa Lee Chulho Kim Jae-Sung Lim Minwoo Lee Kyung-Ho Yu |
| author_sort | Dae Young Cheon |
| collection | DOAJ |
| description | Abstract We aimed to investigate the effects of exercise habit changes on the risk of incident dementia after ischemic stroke using the Korean National Health Insurance Services Database. This study included 223,426 patients with a new diagnosis of ischemic stroke between 2010 and 2016 who underwent two serial ambulatory health checkups. The participants were divided into four categories according to their habit change or regular exercise: persistent non-exercisers, new exercisers, exercise dropouts, and exercise maintainers. The primary outcome was new diagnosis of dementia. Multivariate Cox proportional models were used to assess the effects of changes in exercise habits on the risk of incident dementia. After a median of 4.02 years of follow-up, 22,554 (10.09%) dementia cases were observed. After adjusting for covariates, exercise dropouts, new exercisers, and exercise maintainers were significantly associated with a lower risk of incident dementia than persistent non-exercisers (adjusted hazard ratio [aHR] 0.937; 95% confidence interval [CI] 0.905–0.970, aHR 0.876; 95% CI 0.843–0.909, aHR 0.705; 95% CI 0.677–0.734, respectively). The impact of changes in exercise habit was more prominent in the 40–65 years age group. An energy expenditure ≥ 1000 metabolic equivalents of task-min/wk post-stroke, regardless of pre-stroke physical activity status, was mostly associated with a lower risk of each outcome. In this retrospective cohort study, initiating or continuing moderate-to-vigorous exercise after ischemic stroke was associated with a lower risk of dementia development. Further, pre-stroke regular physical activity also reduced the risk of incident dementia. The promotion of exercise in ambulatory stroke patients may reduce their future risk of incident dementia. |
| first_indexed | 2024-04-09T22:58:50Z |
| format | Article |
| id | doaj.art-d5349528923f4367a5d634e5440ef31d |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T22:58:50Z |
| publishDate | 2023-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-d5349528923f4367a5d634e5440ef31d2023-03-22T11:06:50ZengNature PortfolioScientific Reports2045-23222023-03-011311810.1038/s41598-023-31229-zAssociation between exercise habit changes and incident dementia after ischemic strokeDae Young Cheon0Kyung do Han1Chi-hun Kim2Mi Sun Oh3Byung-Chul Lee4Yerim Kim5Sang-Hwa Lee6Chulho Kim7Jae-Sung Lim8Minwoo Lee9Kyung-Ho Yu10Division of Cardiology, Department of Internal Medicine, Dongtan Sacred Heart HospitalDepartment of Statistics and Actuarial Science, Soongsil UniversityDepartment of Neurology, Hallym University Sacred Heart Hospital, Hallym University College of MedicineDepartment of Neurology, Hallym University Sacred Heart Hospital, Hallym University College of MedicineDepartment of Neurology, Hallym University Sacred Heart Hospital, Hallym University College of MedicineDepartment of Neurology, Kangdong Sacred Heart HospitalDepartment of Neurology, Chuncheon Sacred Heart HospitalDepartment of Neurology, Chuncheon Sacred Heart HospitalDepartment of Neurology, Asan Medical Center, Ulsan University College of MedicineDepartment of Neurology, Hallym University Sacred Heart Hospital, Hallym University College of MedicineDepartment of Neurology, Hallym University Sacred Heart Hospital, Hallym University College of MedicineAbstract We aimed to investigate the effects of exercise habit changes on the risk of incident dementia after ischemic stroke using the Korean National Health Insurance Services Database. This study included 223,426 patients with a new diagnosis of ischemic stroke between 2010 and 2016 who underwent two serial ambulatory health checkups. The participants were divided into four categories according to their habit change or regular exercise: persistent non-exercisers, new exercisers, exercise dropouts, and exercise maintainers. The primary outcome was new diagnosis of dementia. Multivariate Cox proportional models were used to assess the effects of changes in exercise habits on the risk of incident dementia. After a median of 4.02 years of follow-up, 22,554 (10.09%) dementia cases were observed. After adjusting for covariates, exercise dropouts, new exercisers, and exercise maintainers were significantly associated with a lower risk of incident dementia than persistent non-exercisers (adjusted hazard ratio [aHR] 0.937; 95% confidence interval [CI] 0.905–0.970, aHR 0.876; 95% CI 0.843–0.909, aHR 0.705; 95% CI 0.677–0.734, respectively). The impact of changes in exercise habit was more prominent in the 40–65 years age group. An energy expenditure ≥ 1000 metabolic equivalents of task-min/wk post-stroke, regardless of pre-stroke physical activity status, was mostly associated with a lower risk of each outcome. In this retrospective cohort study, initiating or continuing moderate-to-vigorous exercise after ischemic stroke was associated with a lower risk of dementia development. Further, pre-stroke regular physical activity also reduced the risk of incident dementia. The promotion of exercise in ambulatory stroke patients may reduce their future risk of incident dementia.https://doi.org/10.1038/s41598-023-31229-z |
| spellingShingle | Dae Young Cheon Kyung do Han Chi-hun Kim Mi Sun Oh Byung-Chul Lee Yerim Kim Sang-Hwa Lee Chulho Kim Jae-Sung Lim Minwoo Lee Kyung-Ho Yu Association between exercise habit changes and incident dementia after ischemic stroke Scientific Reports |
| title | Association between exercise habit changes and incident dementia after ischemic stroke |
| title_full | Association between exercise habit changes and incident dementia after ischemic stroke |
| title_fullStr | Association between exercise habit changes and incident dementia after ischemic stroke |
| title_full_unstemmed | Association between exercise habit changes and incident dementia after ischemic stroke |
| title_short | Association between exercise habit changes and incident dementia after ischemic stroke |
| title_sort | association between exercise habit changes and incident dementia after ischemic stroke |
| url | https://doi.org/10.1038/s41598-023-31229-z |
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