Association between Higher Serum Cortisol Levels and Decreased Insulin Secretion in a General Population.
Glucocorticoids (GCs) are well known to induce insulin resistance. However, the effect of GCs on insulin secretion has not been well characterized under physiological conditions in human. We here evaluated the effect of GCs on insulin secretion/ß-cell function precisely in a physiological condition....
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5115704?pdf=render |
| _version_ | 1818942470982991872 |
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| author | Aya Kamba Makoto Daimon Hiroshi Murakami Hideyuki Otaka Kota Matsuki Eri Sato Jutaro Tanabe Shinobu Takayasu Yuki Matsuhashi Miyuki Yanagimachi Ken Terui Kazunori Kageyama Itoyo Tokuda Ippei Takahashi Shigeyuki Nakaji |
| author_facet | Aya Kamba Makoto Daimon Hiroshi Murakami Hideyuki Otaka Kota Matsuki Eri Sato Jutaro Tanabe Shinobu Takayasu Yuki Matsuhashi Miyuki Yanagimachi Ken Terui Kazunori Kageyama Itoyo Tokuda Ippei Takahashi Shigeyuki Nakaji |
| author_sort | Aya Kamba |
| collection | DOAJ |
| description | Glucocorticoids (GCs) are well known to induce insulin resistance. However, the effect of GCs on insulin secretion has not been well characterized under physiological conditions in human. We here evaluated the effect of GCs on insulin secretion/ß-cell function precisely in a physiological condition. A population-based study of 1,071 Japanese individuals enrolled in the 2014 Iwaki study (390 men, 681 women; aged 54.1 ± 15.1 years), those excluded individuals taking medication for diabetes or steroid treatment, were enrolled in the present study. Association between serum cortisol levels and insulin resistance/secretion assessed by homeostasis model assessment using fasting blood glucose and insulin levels (HOMA-R and HOMA-ß, respectively) were examined. Univariate linear regression analyses showed correlation of serum cortisol levels with HOMA-ß (ß = -0.134, p <0.001) but not with HOMA-R (ß = 0.042, p = 0.172). Adjustments for age, gender, and the multiple clinical characteristics correlated with HOMA indices showed similar results (HOMA-ß: ß = -0.062, p = 0.025; HOMA-R: ß = -0.023, p = 0.394). The correlation between serum cortisol levels and HOMA-ß remained significant after adjustment for HOMA- R (ß = -0.057, p = 0.034). When subjects were tertiled based on serum cortisol levels, the highest tertile was at greater risk of decreased insulin secretion (defined as lower one third of HOMA-ß (≤70)) than the lowest tertile, after adjustment for multiple factors including HOMA- R (odds ratio 1.26, 95% confidence interval 1.03-1.54). In conclusion, higher serum cortisol levels are significantly associated with decreased insulin secretion in the physiological cortisol range in a Japanese population. |
| first_indexed | 2024-12-20T07:11:57Z |
| format | Article |
| id | doaj.art-d536aff89e9043938b5def7abe4ae6ee |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T07:11:57Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-d536aff89e9043938b5def7abe4ae6ee2022-12-21T19:48:53ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-011111e016607710.1371/journal.pone.0166077Association between Higher Serum Cortisol Levels and Decreased Insulin Secretion in a General Population.Aya KambaMakoto DaimonHiroshi MurakamiHideyuki OtakaKota MatsukiEri SatoJutaro TanabeShinobu TakayasuYuki MatsuhashiMiyuki YanagimachiKen TeruiKazunori KageyamaItoyo TokudaIppei TakahashiShigeyuki NakajiGlucocorticoids (GCs) are well known to induce insulin resistance. However, the effect of GCs on insulin secretion has not been well characterized under physiological conditions in human. We here evaluated the effect of GCs on insulin secretion/ß-cell function precisely in a physiological condition. A population-based study of 1,071 Japanese individuals enrolled in the 2014 Iwaki study (390 men, 681 women; aged 54.1 ± 15.1 years), those excluded individuals taking medication for diabetes or steroid treatment, were enrolled in the present study. Association between serum cortisol levels and insulin resistance/secretion assessed by homeostasis model assessment using fasting blood glucose and insulin levels (HOMA-R and HOMA-ß, respectively) were examined. Univariate linear regression analyses showed correlation of serum cortisol levels with HOMA-ß (ß = -0.134, p <0.001) but not with HOMA-R (ß = 0.042, p = 0.172). Adjustments for age, gender, and the multiple clinical characteristics correlated with HOMA indices showed similar results (HOMA-ß: ß = -0.062, p = 0.025; HOMA-R: ß = -0.023, p = 0.394). The correlation between serum cortisol levels and HOMA-ß remained significant after adjustment for HOMA- R (ß = -0.057, p = 0.034). When subjects were tertiled based on serum cortisol levels, the highest tertile was at greater risk of decreased insulin secretion (defined as lower one third of HOMA-ß (≤70)) than the lowest tertile, after adjustment for multiple factors including HOMA- R (odds ratio 1.26, 95% confidence interval 1.03-1.54). In conclusion, higher serum cortisol levels are significantly associated with decreased insulin secretion in the physiological cortisol range in a Japanese population.http://europepmc.org/articles/PMC5115704?pdf=render |
| spellingShingle | Aya Kamba Makoto Daimon Hiroshi Murakami Hideyuki Otaka Kota Matsuki Eri Sato Jutaro Tanabe Shinobu Takayasu Yuki Matsuhashi Miyuki Yanagimachi Ken Terui Kazunori Kageyama Itoyo Tokuda Ippei Takahashi Shigeyuki Nakaji Association between Higher Serum Cortisol Levels and Decreased Insulin Secretion in a General Population. PLoS ONE |
| title | Association between Higher Serum Cortisol Levels and Decreased Insulin Secretion in a General Population. |
| title_full | Association between Higher Serum Cortisol Levels and Decreased Insulin Secretion in a General Population. |
| title_fullStr | Association between Higher Serum Cortisol Levels and Decreased Insulin Secretion in a General Population. |
| title_full_unstemmed | Association between Higher Serum Cortisol Levels and Decreased Insulin Secretion in a General Population. |
| title_short | Association between Higher Serum Cortisol Levels and Decreased Insulin Secretion in a General Population. |
| title_sort | association between higher serum cortisol levels and decreased insulin secretion in a general population |
| url | http://europepmc.org/articles/PMC5115704?pdf=render |
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