Contribution of Adventitia-Derived Stem and Progenitor Cells to New Vessel Formation in Tumors

Contribution of Adventitia-Derived Stem and Progenitor Cells to New Vessel Formation in Tumors

Blocking tumor vascularization has not yet come to fruition to the extent it was hoped for, as angiogenesis inhibitors have shown only partial success in the clinic. We hypothesized that under-appreciated vascular wall-resident stem and progenitor cells (VW-SPCs) might be involved in tumor vasculari...

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Bibliographic Details
Main Authors: Berin Upcin, Erik Henke, Florian Kleefeldt, Helene Hoffmann, Andreas Rosenwald, Ster Irmak-Sav, Huseyin Bertal Aktas, Uwe Rückschloß, Süleyman Ergün
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cells
Subjects:
vascularization model
tumor spheroids
vascular wall stem and progenitor cells
aortic adventitia
vasculogenesis
tumor-vessel wall-interface model
Online Access:https://www.mdpi.com/2073-4409/10/7/1719

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