Higher Antibody Concentrations in U.S. Health Care Workers Associated with Greater Reactogenicity Post-Vaccination
Multiple factors may be associated with immune responses to SARS-CoV-2 vaccines. Factors potentially related to magnitude and durability of response include age, time, and vaccine reactogenicity. This study analyzed SARS-CoV-2 IgG spike antibody responses following the second dose of vaccine in heal...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/10/4/601 |
| _version_ | 1797434183831781376 |
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| author | Jane A. Dickerson Janet A. Englund Xing Wang Julie C. Brown Danielle M. Zerr Bonnie Strelitz Eileen J. Klein |
| author_facet | Jane A. Dickerson Janet A. Englund Xing Wang Julie C. Brown Danielle M. Zerr Bonnie Strelitz Eileen J. Klein |
| author_sort | Jane A. Dickerson |
| collection | DOAJ |
| description | Multiple factors may be associated with immune responses to SARS-CoV-2 vaccines. Factors potentially related to magnitude and durability of response include age, time, and vaccine reactogenicity. This study analyzed SARS-CoV-2 IgG spike antibody responses following the second dose of vaccine in healthcare workers (HCWs). Data were collected from participants enrolled in a longitudinal SARS-CoV-2 serology study over a 12-month period. Participants completed a survey documenting symptoms post-vaccination. Serum specimens were tested for SARS-CoV-2 IgG antibodies using the Abbott Architect AdvisdeDx SARS-CoV-2 IgGII assay. Antibody levels were compared against time from second vaccine dose, and symptoms following vaccination. Altogether, 335 women (86.6%) and 52 men (13.4%) participated. Median age was 37 years (IQR 30-43). Overall median antibody level was 2150.80 [1246.12, 3556.98] AU/mL (IQR). Age was not associated with antibody concentration (<i>p</i>-value = 0.10). Higher antibody responses (2253 AU/mL vs. 1506 AU/mL; <i>p</i> = 0.008) were found in HCWs with one or more symptoms after the second dose of the vaccine (n = 311). Antibody responses persisted throughout the study period post-vaccination; statistically significant decreases in antibody responses were observed over time (<i>p</i> < 0.001). Higher antibody response was associated with reactogenicity post-vaccine. Age and sex were not associated with higher antibody responses. |
| first_indexed | 2024-03-09T10:28:35Z |
| format | Article |
| id | doaj.art-d537c027a7be49dfb1dedee404aba1da |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-09T10:28:35Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-d537c027a7be49dfb1dedee404aba1da2023-12-01T21:30:39ZengMDPI AGVaccines2076-393X2022-04-0110460110.3390/vaccines10040601Higher Antibody Concentrations in U.S. Health Care Workers Associated with Greater Reactogenicity Post-VaccinationJane A. Dickerson0Janet A. Englund1Xing Wang2Julie C. Brown3Danielle M. Zerr4Bonnie Strelitz5Eileen J. Klein6Seattle Children’s Research Institute, Seattle, WA 98145, USASeattle Children’s Research Institute, Seattle, WA 98145, USASeattle Children’s Research Institute, Seattle, WA 98145, USASeattle Children’s Research Institute, Seattle, WA 98145, USASeattle Children’s Research Institute, Seattle, WA 98145, USASeattle Children’s Research Institute, Seattle, WA 98145, USASeattle Children’s Research Institute, Seattle, WA 98145, USAMultiple factors may be associated with immune responses to SARS-CoV-2 vaccines. Factors potentially related to magnitude and durability of response include age, time, and vaccine reactogenicity. This study analyzed SARS-CoV-2 IgG spike antibody responses following the second dose of vaccine in healthcare workers (HCWs). Data were collected from participants enrolled in a longitudinal SARS-CoV-2 serology study over a 12-month period. Participants completed a survey documenting symptoms post-vaccination. Serum specimens were tested for SARS-CoV-2 IgG antibodies using the Abbott Architect AdvisdeDx SARS-CoV-2 IgGII assay. Antibody levels were compared against time from second vaccine dose, and symptoms following vaccination. Altogether, 335 women (86.6%) and 52 men (13.4%) participated. Median age was 37 years (IQR 30-43). Overall median antibody level was 2150.80 [1246.12, 3556.98] AU/mL (IQR). Age was not associated with antibody concentration (<i>p</i>-value = 0.10). Higher antibody responses (2253 AU/mL vs. 1506 AU/mL; <i>p</i> = 0.008) were found in HCWs with one or more symptoms after the second dose of the vaccine (n = 311). Antibody responses persisted throughout the study period post-vaccination; statistically significant decreases in antibody responses were observed over time (<i>p</i> < 0.001). Higher antibody response was associated with reactogenicity post-vaccine. Age and sex were not associated with higher antibody responses.https://www.mdpi.com/2076-393X/10/4/601SARS-CoV-2vaccine reactionsantibody measurement |
| spellingShingle | Jane A. Dickerson Janet A. Englund Xing Wang Julie C. Brown Danielle M. Zerr Bonnie Strelitz Eileen J. Klein Higher Antibody Concentrations in U.S. Health Care Workers Associated with Greater Reactogenicity Post-Vaccination Vaccines SARS-CoV-2 vaccine reactions antibody measurement |
| title | Higher Antibody Concentrations in U.S. Health Care Workers Associated with Greater Reactogenicity Post-Vaccination |
| title_full | Higher Antibody Concentrations in U.S. Health Care Workers Associated with Greater Reactogenicity Post-Vaccination |
| title_fullStr | Higher Antibody Concentrations in U.S. Health Care Workers Associated with Greater Reactogenicity Post-Vaccination |
| title_full_unstemmed | Higher Antibody Concentrations in U.S. Health Care Workers Associated with Greater Reactogenicity Post-Vaccination |
| title_short | Higher Antibody Concentrations in U.S. Health Care Workers Associated with Greater Reactogenicity Post-Vaccination |
| title_sort | higher antibody concentrations in u s health care workers associated with greater reactogenicity post vaccination |
| topic | SARS-CoV-2 vaccine reactions antibody measurement |
| url | https://www.mdpi.com/2076-393X/10/4/601 |
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