The role of (pro)renin receptor and its soluble form in cardiovascular diseases
The renin-angiotensin system (RAS) is a major classic therapeutic target for cardiovascular diseases. In addition to the circulating RAS, local tissue RAS has been identified in various tissues and plays roles in tissue inflammation and tissue fibrosis. (Pro)renin receptor (PRR) was identified as a...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1086603/full |
| _version_ | 1811170226764513280 |
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| author | Boyang Wang Boyang Wang Boyang Wang Haipeng Jie Haipeng Jie Shuangxi Wang Bo Dong Bo Dong Bo Dong Yunzeng Zou |
| author_facet | Boyang Wang Boyang Wang Boyang Wang Haipeng Jie Haipeng Jie Shuangxi Wang Bo Dong Bo Dong Bo Dong Yunzeng Zou |
| author_sort | Boyang Wang |
| collection | DOAJ |
| description | The renin-angiotensin system (RAS) is a major classic therapeutic target for cardiovascular diseases. In addition to the circulating RAS, local tissue RAS has been identified in various tissues and plays roles in tissue inflammation and tissue fibrosis. (Pro)renin receptor (PRR) was identified as a new member of RAS in 2002. Studies have demonstrated the effects of PRR and its soluble form in local tissue RAS. Moreover, as an important part of vacuolar H+-ATPase, it also contributes to normal lysosome function and cell survival. Evidently, PRR participates in the pathogenesis of cardiovascular diseases and may be a potential therapeutic target of cardiovascular diseases. This review focuses on the effects of PRR and its soluble form on the physiological state, hypertension, myocardial ischemia reperfusion injury, heart failure, metabolic cardiomyopathy, and atherosclerosis. We aimed to investigate the possibilities and challenges of PRR and its soluble form as a new therapeutic target in cardiovascular diseases. |
| first_indexed | 2024-04-10T16:53:31Z |
| format | Article |
| id | doaj.art-d53875ac33f64387a040ffa89fd19898 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-10T16:53:31Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-d53875ac33f64387a040ffa89fd198982023-02-07T10:17:32ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2023-02-011010.3389/fcvm.2023.10866031086603The role of (pro)renin receptor and its soluble form in cardiovascular diseasesBoyang Wang0Boyang Wang1Boyang Wang2Haipeng Jie3Haipeng Jie4Shuangxi Wang5Bo Dong6Bo Dong7Bo Dong8Yunzeng Zou9Department of Cardiology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Cardiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, ChinaDepartment of Cardiology, Shandong University of Traditional Chinese Medicine, Jinan, ChinaDepartment of Cardiology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Cardiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, ChinaKey Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital, Shandong University, Jinan, ChinaDepartment of Cardiology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Cardiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, ChinaDepartment of Cardiology, Shandong University of Traditional Chinese Medicine, Jinan, ChinaShanghai Institute of Cardiovascular Diseases, Zhongshan Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, ChinaThe renin-angiotensin system (RAS) is a major classic therapeutic target for cardiovascular diseases. In addition to the circulating RAS, local tissue RAS has been identified in various tissues and plays roles in tissue inflammation and tissue fibrosis. (Pro)renin receptor (PRR) was identified as a new member of RAS in 2002. Studies have demonstrated the effects of PRR and its soluble form in local tissue RAS. Moreover, as an important part of vacuolar H+-ATPase, it also contributes to normal lysosome function and cell survival. Evidently, PRR participates in the pathogenesis of cardiovascular diseases and may be a potential therapeutic target of cardiovascular diseases. This review focuses on the effects of PRR and its soluble form on the physiological state, hypertension, myocardial ischemia reperfusion injury, heart failure, metabolic cardiomyopathy, and atherosclerosis. We aimed to investigate the possibilities and challenges of PRR and its soluble form as a new therapeutic target in cardiovascular diseases.https://www.frontiersin.org/articles/10.3389/fcvm.2023.1086603/fullhypertensionfibrosiscardiovascular diseaserenin-angiotensin system(pro)renin receptor |
| spellingShingle | Boyang Wang Boyang Wang Boyang Wang Haipeng Jie Haipeng Jie Shuangxi Wang Bo Dong Bo Dong Bo Dong Yunzeng Zou The role of (pro)renin receptor and its soluble form in cardiovascular diseases Frontiers in Cardiovascular Medicine hypertension fibrosis cardiovascular disease renin-angiotensin system (pro)renin receptor |
| title | The role of (pro)renin receptor and its soluble form in cardiovascular diseases |
| title_full | The role of (pro)renin receptor and its soluble form in cardiovascular diseases |
| title_fullStr | The role of (pro)renin receptor and its soluble form in cardiovascular diseases |
| title_full_unstemmed | The role of (pro)renin receptor and its soluble form in cardiovascular diseases |
| title_short | The role of (pro)renin receptor and its soluble form in cardiovascular diseases |
| title_sort | role of pro renin receptor and its soluble form in cardiovascular diseases |
| topic | hypertension fibrosis cardiovascular disease renin-angiotensin system (pro)renin receptor |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1086603/full |
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