Register of patients with familial hypercholesterolemia and patients of very high cardiovascular risk with lipid-lowering therapy underperformance (RENESSANS)
Aim. Russian multicenter register of familial hypercholesterolemia (FH) was transformed into Register of patients with FH and very high cardiovascular risk with insufficient effect of hypolipidemic therapy (RENESSANS Registry) in 2017 The aim of RENESSANS was maximal inclusion of patients not only w...
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| Format: | Article |
| Language: | Russian |
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«FIRMA «SILICEA» LLC
2019-06-01
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| Series: | Российский кардиологический журнал |
| Subjects: | |
| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/3309 |
| _version_ | 1826561199830990848 |
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| author | M. V. Yezhov S. A. Bliznyuk N. A. Tmoyan T. A. Rozhkova D. V. Duplyakov V. A. Salchenko M. A. Kachkovsky I. I. Shaposhnik V. V. Genkel V. S. Gurevich S. А. Urazgildeeva A. V. Tregubov M. V. Muzalevskaya S. S. Bazhan O. V. Timoshchenko I. A. Urvantseva K. G. Kozhokar A. A. Sokolov V. V. Tishko O. I. Boyeva E. V. Bolotova A. M. Namitokov Yu. B. Kushnaryova T. Yu. Kuznetsova V. A. Korneva D. Yu. Bogdanov E. E. Chichina V. M. Solovyov A. I. Ershova A. N. Meshkov V. I. Makogonenko A. S. Galyavich D. I. Sadykova B. V. Pomogaybo O. L. Barbarash V. V. Kashtalap E. A. Shutemova I. G. Isaeva R. A. Khokhlov V. E. Oleynikov I. V. Avdeeva V. V. Malakhov U. V. Chubykina V. O. Konstantinov A. S. Aliyeva V. V. Ovsyannikova G. I. Furmenko T. M. Chernykh O. E. Abashina A. R. Dzhanibekova E. S. Slastnikova L. F. Galimova P. D. Duplyakova M. I. Voyevoda |
| author_facet | M. V. Yezhov S. A. Bliznyuk N. A. Tmoyan T. A. Rozhkova D. V. Duplyakov V. A. Salchenko M. A. Kachkovsky I. I. Shaposhnik V. V. Genkel V. S. Gurevich S. А. Urazgildeeva A. V. Tregubov M. V. Muzalevskaya S. S. Bazhan O. V. Timoshchenko I. A. Urvantseva K. G. Kozhokar A. A. Sokolov V. V. Tishko O. I. Boyeva E. V. Bolotova A. M. Namitokov Yu. B. Kushnaryova T. Yu. Kuznetsova V. A. Korneva D. Yu. Bogdanov E. E. Chichina V. M. Solovyov A. I. Ershova A. N. Meshkov V. I. Makogonenko A. S. Galyavich D. I. Sadykova B. V. Pomogaybo O. L. Barbarash V. V. Kashtalap E. A. Shutemova I. G. Isaeva R. A. Khokhlov V. E. Oleynikov I. V. Avdeeva V. V. Malakhov U. V. Chubykina V. O. Konstantinov A. S. Aliyeva V. V. Ovsyannikova G. I. Furmenko T. M. Chernykh O. E. Abashina A. R. Dzhanibekova E. S. Slastnikova L. F. Galimova P. D. Duplyakova M. I. Voyevoda |
| author_sort | M. V. Yezhov |
| collection | DOAJ |
| description | Aim. Russian multicenter register of familial hypercholesterolemia (FH) was transformed into Register of patients with FH and very high cardiovascular risk with insufficient effect of hypolipidemic therapy (RENESSANS Registry) in 2017 The aim of RENESSANS was maximal inclusion of patients not only with FH, but also those with atherosclerotic cardiovascular diseases (CVD), who did not achieve targeted level of low density lipoprotein cholesterol (LDL-C) using hypolipidemic drug therapy.Material and methods. The RENESSANS Registry is an open, national, observing study that includes patients with definite and probable (according to Dutch lipid clinic network and Simon Broome Registry criteria) heterozygous and homozygous FH, as well as patients of very high cardiovascular risk. There were designed two register forms: for patients with FH and for very high cardiovascular risk patients. Doctors filled out forms in paper and electronic variants. They took into consideration the risk factors of atherosclerosis and anamnesis of CVD, adherence to diet and hypolipidemic therapy. Concentrations of total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C) were measured in blood serum in all centers. LDL-C level was defined according to Friedewald formula: LDL-C=TC-HDL-C-TG/2,2 (mmol/l).Results. The Registry consisted of 1208 FH patients and 497 patients with very high risk (average age 54±13 and 61±8, respectively, 37% men). Baseline levels of lipids were 9,4±2,3 and 6,9±1,5 mmol/l for TC, 6,6±2,1 and 4,5±1,3 mmol/l for LDL-C, respectively. The frequency of hypolipidemic therapy in both groups is 70%, while targeted level of LDL-C was achieved extremely rarely.Conclusion. The results show insufficient adherence and low effectiveness of standard hypolipidemic therapy both in patients with FH and very high cardiovascular risk. PCSK9 inhibitors are recommended for resistant hypercholesterolemia treatment. The RENESSANS Registry allows to improve FH diagnostics, to assess treatment effectiveness and choose patients who need treatment with PCSK9 inhibitors. |
| first_indexed | 2024-04-09T20:46:59Z |
| format | Article |
| id | doaj.art-d539699873c94e3aa2400b582c255079 |
| institution | Directory Open Access Journal |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| last_indexed | 2025-03-14T09:28:23Z |
| publishDate | 2019-06-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj.art-d539699873c94e3aa2400b582c2550792025-03-02T11:42:48Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202019-06-010571310.15829/1560-4071-2019-5-7-132656Register of patients with familial hypercholesterolemia and patients of very high cardiovascular risk with lipid-lowering therapy underperformance (RENESSANS)M. V. Yezhov0S. A. Bliznyuk1N. A. Tmoyan2T. A. Rozhkova3D. V. Duplyakov4V. A. Salchenko5M. A. Kachkovsky6I. I. Shaposhnik7V. V. Genkel8V. S. Gurevich9S. А. Urazgildeeva10A. V. Tregubov11M. V. Muzalevskaya12S. S. Bazhan13O. V. Timoshchenko14I. A. Urvantseva15K. G. Kozhokar16A. A. Sokolov17V. V. Tishko18O. I. Boyeva19E. V. Bolotova20A. M. Namitokov21Yu. B. Kushnaryova22T. Yu. Kuznetsova23V. A. Korneva24D. Yu. Bogdanov25E. E. Chichina26V. M. Solovyov27A. I. Ershova28A. N. Meshkov29V. I. Makogonenko30A. S. Galyavich31D. I. Sadykova32B. V. Pomogaybo33O. L. Barbarash34V. V. Kashtalap35E. A. Shutemova36I. G. Isaeva37R. A. Khokhlov38V. E. Oleynikov39I. V. Avdeeva40V. V. Malakhov41U. V. Chubykina42V. O. Konstantinov43A. S. Aliyeva44V. V. Ovsyannikova45G. I. Furmenko46T. M. Chernykh47O. E. Abashina48A. R. Dzhanibekova49E. S. Slastnikova50L. F. Galimova51P. D. Duplyakova52M. I. Voyevoda53National Medical Research Center of Cardiology, Ministry of Health of RussiaNational Medical Research Center of Cardiology, Ministry of Health of RussiaNational Medical Research Center of Cardiology, Ministry of Health of RussiaNational Medical Research Center of Cardiology, Ministry of Health of RussiaSamara Region Clinical Cardiology DispensarySamara Region Clinical Cardiology DispensaryMedical University “Reaviz”South-Ural State Medical UniversitySouth-Ural State Medical UniversityCenter of Atherosclerosis and Disorders of Lipid Metabolism, St. Petersburg State UniversityCenter of Atherosclerosis and Disorders of Lipid Metabolism, St. Petersburg State UniversityCenter of Atherosclerosis and Disorders of Lipid Metabolism, St. Petersburg State UniversityCenter of Atherosclerosis and Disorders of Lipid Metabolism, St. Petersburg State UniversityResearch Institute for treatment and preventive medicineResearch Institute for treatment and preventive medicineDistrict Cardiac Dispensary, Center for Diagnostic and Cardiovascular SurgeryDistrict Cardiac Dispensary, Center for Diagnostic and Cardiovascular SurgeryMilitary medical academy of S.M. KirovMilitary medical academy of S.M. KirovStavropol State Medical University, Ministry of Health of RussiaSRI — S. V. Ochapovsky Regional Clinical Hospital № 1, Ministry of Health of Krasnodarsky KraiSRI — S. V. Ochapovsky Regional Clinical Hospital № 1, Ministry of Health of Krasnodarsky KraiA.A. Vishnevsky Central Military Clinical Hospital № 3Petrozavodsk State UniversityPetrozavodsk State UniversityVladivostok Clinical Hospital № 1Sakhalin Regional Clinical HospitalYu.E. Veltischev Research and Clinical Institute for Pediatrics, N. I. Pirogov Russian National Research Medical University (RNRMU)National Medical Research Center for Preventive MedicineNational Medical Research Center for Preventive MedicineNational Medical Research Center for Preventive MedicineKazan State Medical University, Ministry of Health of RussiaKazan State Medical University, Ministry of Health of Russia413 Military hospitalResearch Institute for Complex Issues of Cardiovascular DiseasesResearch Institute for Complex Issues of Cardiovascular DiseasesCardiology DispensaryCardiology DispensaryVoronezh Regional Clinical Consulting and Diagnostic CenterPenza State UniversityPenza State UniversityNational Medical Research Center of Cardiology, Ministry of Health of RussiaNational Medical Research Center of Cardiology, Ministry of Health of RussiaI.I. Mechnikov North-Western State Medical University, Ministry of Health of RussiaAlmazov National Medical Research CenterN.N. Burdenko Voronezh State Medical University, Ministry of Health of RussiaN.N. Burdenko Voronezh State Medical University, Ministry of Health of RussiaN.N. Burdenko Voronezh State Medical University, Ministry of Health of RussiaV.D. Seredavin Samara Regional Clinical HospitalCity Clinical Hospital № 3Republican Children’s Clinical Hospital, Ministry of Health of TatarstanRepublican Children’s Clinical Hospital, Ministry of Health of TatarstanSamara State Medical University, Ministry of Health of RussiaResearch Institute for treatment and preventive medicineAim. Russian multicenter register of familial hypercholesterolemia (FH) was transformed into Register of patients with FH and very high cardiovascular risk with insufficient effect of hypolipidemic therapy (RENESSANS Registry) in 2017 The aim of RENESSANS was maximal inclusion of patients not only with FH, but also those with atherosclerotic cardiovascular diseases (CVD), who did not achieve targeted level of low density lipoprotein cholesterol (LDL-C) using hypolipidemic drug therapy.Material and methods. The RENESSANS Registry is an open, national, observing study that includes patients with definite and probable (according to Dutch lipid clinic network and Simon Broome Registry criteria) heterozygous and homozygous FH, as well as patients of very high cardiovascular risk. There were designed two register forms: for patients with FH and for very high cardiovascular risk patients. Doctors filled out forms in paper and electronic variants. They took into consideration the risk factors of atherosclerosis and anamnesis of CVD, adherence to diet and hypolipidemic therapy. Concentrations of total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C) were measured in blood serum in all centers. LDL-C level was defined according to Friedewald formula: LDL-C=TC-HDL-C-TG/2,2 (mmol/l).Results. The Registry consisted of 1208 FH patients and 497 patients with very high risk (average age 54±13 and 61±8, respectively, 37% men). Baseline levels of lipids were 9,4±2,3 and 6,9±1,5 mmol/l for TC, 6,6±2,1 and 4,5±1,3 mmol/l for LDL-C, respectively. The frequency of hypolipidemic therapy in both groups is 70%, while targeted level of LDL-C was achieved extremely rarely.Conclusion. The results show insufficient adherence and low effectiveness of standard hypolipidemic therapy both in patients with FH and very high cardiovascular risk. PCSK9 inhibitors are recommended for resistant hypercholesterolemia treatment. The RENESSANS Registry allows to improve FH diagnostics, to assess treatment effectiveness and choose patients who need treatment with PCSK9 inhibitors.https://russjcardiol.elpub.ru/jour/article/view/3309familial hypercholesterolemiaregistryatherosclerotic cardiovascular diseasesvery high risk. |
| spellingShingle | M. V. Yezhov S. A. Bliznyuk N. A. Tmoyan T. A. Rozhkova D. V. Duplyakov V. A. Salchenko M. A. Kachkovsky I. I. Shaposhnik V. V. Genkel V. S. Gurevich S. А. Urazgildeeva A. V. Tregubov M. V. Muzalevskaya S. S. Bazhan O. V. Timoshchenko I. A. Urvantseva K. G. Kozhokar A. A. Sokolov V. V. Tishko O. I. Boyeva E. V. Bolotova A. M. Namitokov Yu. B. Kushnaryova T. Yu. Kuznetsova V. A. Korneva D. Yu. Bogdanov E. E. Chichina V. M. Solovyov A. I. Ershova A. N. Meshkov V. I. Makogonenko A. S. Galyavich D. I. Sadykova B. V. Pomogaybo O. L. Barbarash V. V. Kashtalap E. A. Shutemova I. G. Isaeva R. A. Khokhlov V. E. Oleynikov I. V. Avdeeva V. V. Malakhov U. V. Chubykina V. O. Konstantinov A. S. Aliyeva V. V. Ovsyannikova G. I. Furmenko T. M. Chernykh O. E. Abashina A. R. Dzhanibekova E. S. Slastnikova L. F. Galimova P. D. Duplyakova M. I. Voyevoda Register of patients with familial hypercholesterolemia and patients of very high cardiovascular risk with lipid-lowering therapy underperformance (RENESSANS) Российский кардиологический журнал familial hypercholesterolemia registry atherosclerotic cardiovascular diseases very high risk. |
| title | Register of patients with familial hypercholesterolemia and patients of very high cardiovascular risk with lipid-lowering therapy underperformance (RENESSANS) |
| title_full | Register of patients with familial hypercholesterolemia and patients of very high cardiovascular risk with lipid-lowering therapy underperformance (RENESSANS) |
| title_fullStr | Register of patients with familial hypercholesterolemia and patients of very high cardiovascular risk with lipid-lowering therapy underperformance (RENESSANS) |
| title_full_unstemmed | Register of patients with familial hypercholesterolemia and patients of very high cardiovascular risk with lipid-lowering therapy underperformance (RENESSANS) |
| title_short | Register of patients with familial hypercholesterolemia and patients of very high cardiovascular risk with lipid-lowering therapy underperformance (RENESSANS) |
| title_sort | register of patients with familial hypercholesterolemia and patients of very high cardiovascular risk with lipid lowering therapy underperformance renessans |
| topic | familial hypercholesterolemia registry atherosclerotic cardiovascular diseases very high risk. |
| url | https://russjcardiol.elpub.ru/jour/article/view/3309 |
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