Treatment with oral active vitamin D is associated with decreased risk of peritonitis and improved survival in patients on peritoneal dialysis.
Peritonitis is a major complication of peritoneal dialysis (PD) being associated with hospitalization, catheter loss, technique failure, and increased mortality. Data on incidence rates and risk factors for peritonitis episodes vary between centers. In seven Austrian PD units clinical and laboratory...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3699473?pdf=render |
| _version_ | 1819112127544164352 |
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| author | Julia Kerschbaum Andreas Vychytil Karl Lhotta Friedrich C Prischl Martin Wiesholzer Veronika Machhold-Fabrizii Gertrude Kopriva-Altfahrt Christoph Schwarz Peter Balcke Rainer Oberbauer Reinhard Kramar Paul König Michael Rudnicki |
| author_facet | Julia Kerschbaum Andreas Vychytil Karl Lhotta Friedrich C Prischl Martin Wiesholzer Veronika Machhold-Fabrizii Gertrude Kopriva-Altfahrt Christoph Schwarz Peter Balcke Rainer Oberbauer Reinhard Kramar Paul König Michael Rudnicki |
| author_sort | Julia Kerschbaum |
| collection | DOAJ |
| description | Peritonitis is a major complication of peritoneal dialysis (PD) being associated with hospitalization, catheter loss, technique failure, and increased mortality. Data on incidence rates and risk factors for peritonitis episodes vary between centers. In seven Austrian PD units clinical and laboratory data on each peritonitis episode were collected from all patients (n = 726) who performed PD between January 2000 and December 2009. The peritonitis incidence rate was 0.32 episodes/patient-year. In a multivariate analysis the risk of peritonitis was decreased by 57% in patients treated with oral active vitamin D (HR 0.43; 95% CI 0.28-0.64). Renal disease classified as "other or unknown" (HR 1.65; 95% CI 1.08-2.53) and serum albumin <3500 mg/dl (HR 1.49; 95% CI 1.04-2.15) were also associated with an increased risk of peritonitis. Albumin levels <3500 mg/dl (HR 1.89; 95% CI 1.13-3.17), age (HR 1.06 per year; 95% CI 1.03-1.09), and cardiomyopathy (HR 3.01; 95% CI 1.62-5.59) were associated with increased mortality, whereas treatment with oral active vitamin D was associated with a significantly lower risk of death (HR 0.46; 95% CI 0.27-0.81). In this retrospective multi-center study we identified several factors being related to increased risk of peritonitis in PD patients. Treatment with oral active vitamin D was identified as being independently associated with decreased risk of peritonitis, and decreased all-cause mortality in PD patients. |
| first_indexed | 2024-12-22T04:08:34Z |
| format | Article |
| id | doaj.art-d539cfed5d39489c83b1ac78a80ee0a2 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T04:08:34Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-d539cfed5d39489c83b1ac78a80ee0a22022-12-21T18:39:35ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0187e6783610.1371/journal.pone.0067836Treatment with oral active vitamin D is associated with decreased risk of peritonitis and improved survival in patients on peritoneal dialysis.Julia KerschbaumAndreas VychytilKarl LhottaFriedrich C PrischlMartin WiesholzerVeronika Machhold-FabriziiGertrude Kopriva-AltfahrtChristoph SchwarzPeter BalckeRainer OberbauerReinhard KramarPaul KönigMichael RudnickiPeritonitis is a major complication of peritoneal dialysis (PD) being associated with hospitalization, catheter loss, technique failure, and increased mortality. Data on incidence rates and risk factors for peritonitis episodes vary between centers. In seven Austrian PD units clinical and laboratory data on each peritonitis episode were collected from all patients (n = 726) who performed PD between January 2000 and December 2009. The peritonitis incidence rate was 0.32 episodes/patient-year. In a multivariate analysis the risk of peritonitis was decreased by 57% in patients treated with oral active vitamin D (HR 0.43; 95% CI 0.28-0.64). Renal disease classified as "other or unknown" (HR 1.65; 95% CI 1.08-2.53) and serum albumin <3500 mg/dl (HR 1.49; 95% CI 1.04-2.15) were also associated with an increased risk of peritonitis. Albumin levels <3500 mg/dl (HR 1.89; 95% CI 1.13-3.17), age (HR 1.06 per year; 95% CI 1.03-1.09), and cardiomyopathy (HR 3.01; 95% CI 1.62-5.59) were associated with increased mortality, whereas treatment with oral active vitamin D was associated with a significantly lower risk of death (HR 0.46; 95% CI 0.27-0.81). In this retrospective multi-center study we identified several factors being related to increased risk of peritonitis in PD patients. Treatment with oral active vitamin D was identified as being independently associated with decreased risk of peritonitis, and decreased all-cause mortality in PD patients.http://europepmc.org/articles/PMC3699473?pdf=render |
| spellingShingle | Julia Kerschbaum Andreas Vychytil Karl Lhotta Friedrich C Prischl Martin Wiesholzer Veronika Machhold-Fabrizii Gertrude Kopriva-Altfahrt Christoph Schwarz Peter Balcke Rainer Oberbauer Reinhard Kramar Paul König Michael Rudnicki Treatment with oral active vitamin D is associated with decreased risk of peritonitis and improved survival in patients on peritoneal dialysis. PLoS ONE |
| title | Treatment with oral active vitamin D is associated with decreased risk of peritonitis and improved survival in patients on peritoneal dialysis. |
| title_full | Treatment with oral active vitamin D is associated with decreased risk of peritonitis and improved survival in patients on peritoneal dialysis. |
| title_fullStr | Treatment with oral active vitamin D is associated with decreased risk of peritonitis and improved survival in patients on peritoneal dialysis. |
| title_full_unstemmed | Treatment with oral active vitamin D is associated with decreased risk of peritonitis and improved survival in patients on peritoneal dialysis. |
| title_short | Treatment with oral active vitamin D is associated with decreased risk of peritonitis and improved survival in patients on peritoneal dialysis. |
| title_sort | treatment with oral active vitamin d is associated with decreased risk of peritonitis and improved survival in patients on peritoneal dialysis |
| url | http://europepmc.org/articles/PMC3699473?pdf=render |
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