Fc Receptor-Like 6 (FCRL6) Discloses Progenitor B Cell Heterogeneity That Correlates With Pre-BCR Dependent and Independent Pathways of Natural Antibody Selection

Fc Receptor-Like 6 (FCRL6) Discloses Progenitor B Cell Heterogeneity That Correlates With Pre-BCR Dependent and Independent Pathways of Natural Antibody Selection

B-1a cells produce “natural” antibodies (Abs) to neutralize pathogens and clear neo self-antigens, but the fundamental selection mechanisms that shape their polyreactive repertoires are poorly understood. Here, we identified a B cell progenitor subset defined by Fc receptor-like 6 (FCRL6) expression...

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Bibliographic Details
Main Authors: Kazuhito Honjo, Woong-Jai Won, Rodney G. King, Lara Ianov, David K. Crossman, Juliet L. Easlick, Mikhail A. Shakhmatov, Mohamed Khass, Andre M. Vale, Robert P. Stephan, Ran Li, Randall S. Davis
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Immunology
Subjects:
B-1 cells
innate-like B cells
natural antibodies
antibody repertoire
lymphocyte development
lymphocyte selection
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00082/full

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