REPercussions: how geminiviruses recruit host factors for replication
Circular single-stranded DNA viruses of the family Geminiviridae encode replication-associated protein (Rep), which is a multifunctional protein involved in virus DNA replication, transcription of virus genes, and suppression of host defense responses. Geminivirus genomes are replicated through the...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-09-01
|
| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1224221/full |
| _version_ | 1797679258796032000 |
|---|---|
| author | Sara Shakir Muhammad Mubin Nazia Nahid Saad Serfraz Muhammad Amir Qureshi Taek-Kyun Lee Iram Liaqat Sukchan Lee Muhammad Shah Nawaz-ul-Rehman |
| author_facet | Sara Shakir Muhammad Mubin Nazia Nahid Saad Serfraz Muhammad Amir Qureshi Taek-Kyun Lee Iram Liaqat Sukchan Lee Muhammad Shah Nawaz-ul-Rehman |
| author_sort | Sara Shakir |
| collection | DOAJ |
| description | Circular single-stranded DNA viruses of the family Geminiviridae encode replication-associated protein (Rep), which is a multifunctional protein involved in virus DNA replication, transcription of virus genes, and suppression of host defense responses. Geminivirus genomes are replicated through the interaction between virus Rep and several host proteins. The Rep also interacts with itself and the virus replication enhancer protein (REn), which is another essential component of the geminivirus replicase complex that interacts with host DNA polymerases α and δ. Recent studies revealed the structural and functional complexities of geminivirus Rep, which is believed to have evolved from plasmids containing a signature domain (HUH) for single-stranded DNA binding with nuclease activity. The Rep coding sequence encompasses the entire coding sequence for AC4, which is intricately embedded within it, and performs several overlapping functions like Rep, supporting virus infection. This review investigated the structural and functional diversity of the geminivirus Rep. |
| first_indexed | 2024-03-11T23:11:55Z |
| format | Article |
| id | doaj.art-d53c7d3406d644fdb543568cd976cb49 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-03-11T23:11:55Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-d53c7d3406d644fdb543568cd976cb492023-09-21T08:00:43ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2023-09-011410.3389/fmicb.2023.12242211224221REPercussions: how geminiviruses recruit host factors for replicationSara Shakir0Muhammad Mubin1Nazia Nahid2Saad Serfraz3Muhammad Amir Qureshi4Taek-Kyun Lee5Iram Liaqat6Sukchan Lee7Muhammad Shah Nawaz-ul-Rehman8Plant Genetics Lab, Gembloux Agro-Bio Tech, University of Liѐge, Gembloux, BelgiumVirology Lab, Center for Agricultural Biochemistry and Biotechnology, University of Agriculture, Faisalabad, Faisalabad, PakistanDepartment of Bioinformatics and Biotechnology, Government College University, Faisalabad, PakistanVirology Lab, Center for Agricultural Biochemistry and Biotechnology, University of Agriculture, Faisalabad, Faisalabad, PakistanDepartment of Integrative Biotechnology, Sungkyunkwan University, Suwon, Republic of KoreaRisk Assessment Research Center, Korea Institute of Ocean Science and Technology, Geoje, Republic of KoreaMicrobiology Lab, Department of Zoology, Government College University, Lahore, PakistanDepartment of Integrative Biotechnology, Sungkyunkwan University, Suwon, Republic of KoreaVirology Lab, Center for Agricultural Biochemistry and Biotechnology, University of Agriculture, Faisalabad, Faisalabad, PakistanCircular single-stranded DNA viruses of the family Geminiviridae encode replication-associated protein (Rep), which is a multifunctional protein involved in virus DNA replication, transcription of virus genes, and suppression of host defense responses. Geminivirus genomes are replicated through the interaction between virus Rep and several host proteins. The Rep also interacts with itself and the virus replication enhancer protein (REn), which is another essential component of the geminivirus replicase complex that interacts with host DNA polymerases α and δ. Recent studies revealed the structural and functional complexities of geminivirus Rep, which is believed to have evolved from plasmids containing a signature domain (HUH) for single-stranded DNA binding with nuclease activity. The Rep coding sequence encompasses the entire coding sequence for AC4, which is intricately embedded within it, and performs several overlapping functions like Rep, supporting virus infection. This review investigated the structural and functional diversity of the geminivirus Rep.https://www.frontiersin.org/articles/10.3389/fmicb.2023.1224221/fullgeminivirusesreplicationpathogenicityvirus interactionhost factors |
| spellingShingle | Sara Shakir Muhammad Mubin Nazia Nahid Saad Serfraz Muhammad Amir Qureshi Taek-Kyun Lee Iram Liaqat Sukchan Lee Muhammad Shah Nawaz-ul-Rehman REPercussions: how geminiviruses recruit host factors for replication Frontiers in Microbiology geminiviruses replication pathogenicity virus interaction host factors |
| title | REPercussions: how geminiviruses recruit host factors for replication |
| title_full | REPercussions: how geminiviruses recruit host factors for replication |
| title_fullStr | REPercussions: how geminiviruses recruit host factors for replication |
| title_full_unstemmed | REPercussions: how geminiviruses recruit host factors for replication |
| title_short | REPercussions: how geminiviruses recruit host factors for replication |
| title_sort | repercussions how geminiviruses recruit host factors for replication |
| topic | geminiviruses replication pathogenicity virus interaction host factors |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1224221/full |
| work_keys_str_mv | AT sarashakir repercussionshowgeminivirusesrecruithostfactorsforreplication AT muhammadmubin repercussionshowgeminivirusesrecruithostfactorsforreplication AT nazianahid repercussionshowgeminivirusesrecruithostfactorsforreplication AT saadserfraz repercussionshowgeminivirusesrecruithostfactorsforreplication AT muhammadamirqureshi repercussionshowgeminivirusesrecruithostfactorsforreplication AT taekkyunlee repercussionshowgeminivirusesrecruithostfactorsforreplication AT iramliaqat repercussionshowgeminivirusesrecruithostfactorsforreplication AT sukchanlee repercussionshowgeminivirusesrecruithostfactorsforreplication AT muhammadshahnawazulrehman repercussionshowgeminivirusesrecruithostfactorsforreplication |