Prioritizing susceptibility genes for the prognosis of male-pattern baldness with transcriptome-wide association study
Abstract Background Male-pattern baldness (MPB) is the most common cause of hair loss in men. It can be categorized into three types: type 2 (T2), type 3 (T3), and type 4 (T4), with type 1 (T1) being considered normal. Although various MPB-associated genetic variants have been suggested, a comprehen...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-04-01
|
| Series: | Human Genomics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40246-024-00591-y |
| _version_ | 1797219695277899776 |
|---|---|
| author | Eunyoung Choi Jaeseung Song Yubin Lee Yeonbin Jeong Wonhee Jang |
| author_facet | Eunyoung Choi Jaeseung Song Yubin Lee Yeonbin Jeong Wonhee Jang |
| author_sort | Eunyoung Choi |
| collection | DOAJ |
| description | Abstract Background Male-pattern baldness (MPB) is the most common cause of hair loss in men. It can be categorized into three types: type 2 (T2), type 3 (T3), and type 4 (T4), with type 1 (T1) being considered normal. Although various MPB-associated genetic variants have been suggested, a comprehensive study for linking these variants to gene expression regulation has not been performed to the best of our knowledge. Results In this study, we prioritized MPB-related tissue panels using tissue-specific enrichment analysis and utilized single-tissue panels from genotype-tissue expression version 8, as well as cross-tissue panels from context-specific genetics. Through a transcriptome-wide association study and colocalization analysis, we identified 52, 75, and 144 MPB associations for T2, T3, and T4, respectively. To assess the causality of MPB genes, we performed a conditional and joint analysis, which revealed 10, 11, and 54 putative causality genes for T2, T3, and T4, respectively. Finally, we conducted drug repositioning and identified potential drug candidates that are connected to MPB-associated genes. Conclusions Overall, through an integrative analysis of gene expression and genotype data, we have identified robust MPB susceptibility genes that may help uncover the underlying molecular mechanisms and the novel drug candidates that may alleviate MPB. |
| first_indexed | 2024-04-24T12:37:44Z |
| format | Article |
| id | doaj.art-d53c906b15c44335a0e6cfb284ada755 |
| institution | Directory Open Access Journal |
| issn | 1479-7364 |
| language | English |
| last_indexed | 2024-04-24T12:37:44Z |
| publishDate | 2024-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Human Genomics |
| spelling | doaj.art-d53c906b15c44335a0e6cfb284ada7552024-04-07T11:24:47ZengBMCHuman Genomics1479-73642024-04-0118111510.1186/s40246-024-00591-yPrioritizing susceptibility genes for the prognosis of male-pattern baldness with transcriptome-wide association studyEunyoung Choi0Jaeseung Song1Yubin Lee2Yeonbin Jeong3Wonhee Jang4Department of Life Sciences, Dongguk UniversityDepartment of Life Sciences, Dongguk UniversityDepartment of Life Sciences, Dongguk UniversityDepartment of Life Sciences, Dongguk UniversityDepartment of Life Sciences, Dongguk UniversityAbstract Background Male-pattern baldness (MPB) is the most common cause of hair loss in men. It can be categorized into three types: type 2 (T2), type 3 (T3), and type 4 (T4), with type 1 (T1) being considered normal. Although various MPB-associated genetic variants have been suggested, a comprehensive study for linking these variants to gene expression regulation has not been performed to the best of our knowledge. Results In this study, we prioritized MPB-related tissue panels using tissue-specific enrichment analysis and utilized single-tissue panels from genotype-tissue expression version 8, as well as cross-tissue panels from context-specific genetics. Through a transcriptome-wide association study and colocalization analysis, we identified 52, 75, and 144 MPB associations for T2, T3, and T4, respectively. To assess the causality of MPB genes, we performed a conditional and joint analysis, which revealed 10, 11, and 54 putative causality genes for T2, T3, and T4, respectively. Finally, we conducted drug repositioning and identified potential drug candidates that are connected to MPB-associated genes. Conclusions Overall, through an integrative analysis of gene expression and genotype data, we have identified robust MPB susceptibility genes that may help uncover the underlying molecular mechanisms and the novel drug candidates that may alleviate MPB.https://doi.org/10.1186/s40246-024-00591-yDrug repositioningGene prioritizationMale-pattern baldnessPhenome-wide association studyTranscriptome-wide association study |
| spellingShingle | Eunyoung Choi Jaeseung Song Yubin Lee Yeonbin Jeong Wonhee Jang Prioritizing susceptibility genes for the prognosis of male-pattern baldness with transcriptome-wide association study Human Genomics Drug repositioning Gene prioritization Male-pattern baldness Phenome-wide association study Transcriptome-wide association study |
| title | Prioritizing susceptibility genes for the prognosis of male-pattern baldness with transcriptome-wide association study |
| title_full | Prioritizing susceptibility genes for the prognosis of male-pattern baldness with transcriptome-wide association study |
| title_fullStr | Prioritizing susceptibility genes for the prognosis of male-pattern baldness with transcriptome-wide association study |
| title_full_unstemmed | Prioritizing susceptibility genes for the prognosis of male-pattern baldness with transcriptome-wide association study |
| title_short | Prioritizing susceptibility genes for the prognosis of male-pattern baldness with transcriptome-wide association study |
| title_sort | prioritizing susceptibility genes for the prognosis of male pattern baldness with transcriptome wide association study |
| topic | Drug repositioning Gene prioritization Male-pattern baldness Phenome-wide association study Transcriptome-wide association study |
| url | https://doi.org/10.1186/s40246-024-00591-y |
| work_keys_str_mv | AT eunyoungchoi prioritizingsusceptibilitygenesfortheprognosisofmalepatternbaldnesswithtranscriptomewideassociationstudy AT jaeseungsong prioritizingsusceptibilitygenesfortheprognosisofmalepatternbaldnesswithtranscriptomewideassociationstudy AT yubinlee prioritizingsusceptibilitygenesfortheprognosisofmalepatternbaldnesswithtranscriptomewideassociationstudy AT yeonbinjeong prioritizingsusceptibilitygenesfortheprognosisofmalepatternbaldnesswithtranscriptomewideassociationstudy AT wonheejang prioritizingsusceptibilitygenesfortheprognosisofmalepatternbaldnesswithtranscriptomewideassociationstudy |