Disruption of ATRX-RNA interactions uncovers roles in ATRX localization and PRC2 function

ATRX is an RNA binding protein that mediates targeting of polycomb repressive complex 2 (PRC2) to genomic sites. Here the authors identify the RNA binding region and show that the RNA binding is required for ATRX localization and for its recruitment of PRC2 to a subset of polycomb targets.

ग्रंथसूची विवरण
मुख्य लेखकों: Wenqing Ren, Nicole Medeiros, Robert Warneford-Thomson, Phillip Wulfridge, Qingqing Yan, Joyce Bian, Simone Sidoli, Benjamin A. Garcia, Emmanuel Skordalakes, Eric Joyce, Roberto Bonasio, Kavitha Sarma
स्वरूप: लेख
भाषा:English
प्रकाशित: Nature Portfolio 2020-05-01
श्रृंखला:Nature Communications
ऑनलाइन पहुंच:https://doi.org/10.1038/s41467-020-15902-9
विवरण
सारांश:ATRX is an RNA binding protein that mediates targeting of polycomb repressive complex 2 (PRC2) to genomic sites. Here the authors identify the RNA binding region and show that the RNA binding is required for ATRX localization and for its recruitment of PRC2 to a subset of polycomb targets.
आईएसएसएन:2041-1723