Disruption of ATRX-RNA interactions uncovers roles in ATRX localization and PRC2 function
ATRX is an RNA binding protein that mediates targeting of polycomb repressive complex 2 (PRC2) to genomic sites. Here the authors identify the RNA binding region and show that the RNA binding is required for ATRX localization and for its recruitment of PRC2 to a subset of polycomb targets.
Bibliographische Detailangaben
| Hauptverfasser: |
Wenqing Ren,
Nicole Medeiros,
Robert Warneford-Thomson,
Phillip Wulfridge,
Qingqing Yan,
Joyce Bian,
Simone Sidoli,
Benjamin A. Garcia,
Emmanuel Skordalakes,
Eric Joyce,
Roberto Bonasio,
Kavitha Sarma |
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| Format: | Artikel
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| Sprache: | English |
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| Veröffentlicht: |
Nature Portfolio
2020-05-01
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| Schriftenreihe: | Nature Communications
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| Online Zugang: | https://doi.org/10.1038/s41467-020-15902-9
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