Disruption of ATRX-RNA interactions uncovers roles in ATRX localization and PRC2 function
ATRX is an RNA binding protein that mediates targeting of polycomb repressive complex 2 (PRC2) to genomic sites. Here the authors identify the RNA binding region and show that the RNA binding is required for ATRX localization and for its recruitment of PRC2 to a subset of polycomb targets.
| Հիմնական հեղինակներ: | , , , , , , , , , , , |
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| Ձևաչափ: | Հոդված |
| Լեզու: | English |
| Հրապարակվել է: |
Nature Portfolio
2020-05-01
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| Շարք: | Nature Communications |
| Առցանց հասանելիություն: | https://doi.org/10.1038/s41467-020-15902-9 |