Increased Akt-Driven Glycolysis Is the Basis for the Higher Potency of CD137L-DCs
CD137 ligand-induced dendritic cells (CD137L-DCs) are a new type of dendritic cells (DCs) that induce strong cytotoxic T cell responses. Investigating the metabolic activity as a potential contributing factor for their potency, we find a significantly higher rate of glycolysis in CD137L-DCs than in...
Main Authors: | Qun Zeng, Karthik Mallilankaraman, Herbert Schwarz |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2019-04-01
|
Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.00868/full |
Similar Items
-
The Progress of Investigating the CD137-CD137L Axis as a Potential Target for Systemic Lupus Erythematosus
by: Anselm Mak, et al.
Published: (2019-09-01) -
Regulatory T Cells Inhibit T Cell Activity by Downregulating CD137 Ligand via CD137 Trogocytosis
by: Khang Luu, et al.
Published: (2021-02-01) -
Lysophosphatidic Acid Induces Aerobic Glycolysis, Lipogenesis, and Increased Amino Acid Uptake in BV-2 Microglia
by: Lisha Joshi, et al.
Published: (2021-02-01) -
Knockdown of ANP32E inhibits colorectal cancer cell growth and glycolysis by regulating the AKT/mTOR pathway
by: Liu Jiaojiao, et al.
Published: (2024-03-01) -
Tumor Cell Glycolysis—At the Crossroad of Epithelial–Mesenchymal Transition and Autophagy
by: Fabrizio Marcucci, et al.
Published: (2022-03-01)