Systemically Silencing Long Non-coding RNAs Maclpil With Short Interfering RNA Nanoparticles Alleviates Experimental Ischemic Stroke by Promoting Macrophage Apoptosis and Anti-inflammatory Activation

Systemically Silencing Long Non-coding RNAs Maclpil With Short Interfering RNA Nanoparticles Alleviates Experimental Ischemic Stroke by Promoting Macrophage Apoptosis and Anti-inflammatory Activation

BackgroundMaclpil is a proinflammatory long non-coding RNA highly expressed on monocyte-derived macrophages in the ischemic brain. This study investigated the impact and the mechanisms of systemically delivering nanoparticle Maclpil short interfering RNA (siRNA) on experimental ischemic stroke in a...

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Bibliographic Details
Main Authors: Yan Wang, Cuiying Liu, Yong Chen, Tiffany Chen, Tao Han, Lixiang Xue, Baohui Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
ischemic stroke
neuroinflammation
macrophages
lncRNA maclpil
SiRNA nanoparticles
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.876087/full

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